DOT1/YDR440W Literature Guide Help

Other names published for DOT1: PCH1, KMT4, YDR440W

DOT1 - Function/Process (43)

ReferenceOther Genes Addressed
De Vos D, et al.  (2011) Progressive methylation of ageing histones by Dot1 functions as a timer. EMBO Rep 12(9):956-62
Stulemeijer IJ, et al.  (2011) Dot1 binding induces chromatin rearrangements by histone methylation-dependent and -independent mechanisms. Epigenetics Chromatin 4(1):2
Takahashi YH, et al.  (2011) Dot1 and Histone H3K79 Methylation in Natural Telomeric and HM Silencing. Mol Cell 42(1):118-26
Tatum D and Li S  (2011) Evidence that the histone methyltransferase Dot1 mediates global genomic repair by methylating histone H3 on lysine 79. J Biol Chem 286(20):17530-5
Wlodarski T, et al.  (2011) Comprehensive Structural and Substrate Specificity Classification of the Saccharomyces cerevisiae Methyltransferome. PLoS One 6(8):e23168
Conde F, et al.  (2010) Regulation of tolerance to DNA alkylating damage by Dot1 and Rad53 in Saccharomyces cerevisiae. DNA Repair (Amst) 9(10):1038-49
Levesque N, et al.  (2010) Loss of H3 K79 trimethylation leads to suppression of Rtt107-dependent DNA damage sensitivity through the translesion synthesis pathway. J Biol Chem 285(45):35113-22
Weber JM and Ehrenhofer-Murray AE  (2010) Design of a minimal silencer for the silent mating-type locus HML of Saccharomyces cerevisiae. Nucleic Acids Res 38(22):7991-8000
Conde F, et al.  (2009) The Dot1 Histone Methyltransferase and the Rad9 Checkpoint Adaptor Contribute to Cohesin-Dependent Double-Strand Break Repair by Sister Chromatid Recombination in Saccharomyces cerevisiae. Genetics 182(2):437-46
Martino F, et al.  (2009) Reconstitution of yeast silent chromatin: multiple contact sites and O-AADPR binding load SIR complexes onto nucleosomes in vitro. Mol Cell 33(3):323-34
Verzijlbergen KF, et al.  (2009) Multiple histone modifications in euchromatin promote heterochromatin formation by redundant mechanisms in Saccharomyces cerevisiae. BMC Mol Biol 10:76
Yousef AF, et al.  (2009) Requirements for E1A dependent transcription in the yeast Saccharomyces cerevisiae. BMC Mol Biol 10:32
Frederiks F, et al.  (2008) Nonprocessive methylation by Dot1 leads to functional redundancy of histone H3K79 methylation states. Nat Struct Mol Biol 15(6):550-7
Lazzaro F, et al.  (2008) Histone methyltransferase Dot1 and Rad9 inhibit single-stranded DNA accumulation at DSBs and uncapped telomeres. EMBO J 27(10):1502-12
Merker JD, et al.  (2008) The histone methylase Set2p and the histone deacetylase Rpd3p repress meiotic recombination at the HIS4 meiotic recombination hotspot in Saccharomyces cerevisiae. DNA Repair (Amst) 7(8):1298-308
Yousef AF, et al.  (2008) Coactivator requirements for p53-dependent transcription in the yeast Saccharomyces cerevisiae. Int J Cancer 122(4):942-6
van Welsem T, et al.  (2008) Synthetic lethal screens identify gene silencing processes in yeast and implicate the acetylated amino terminus of Sir3 in recognition of the nucleosome core. Mol Cell Biol 28(11):3861-72
Altaf M, et al.  (2007) Interplay of chromatin modifiers on a short basic patch of histone H4 tail defines the boundary of telomeric heterochromatin. Mol Cell 28(6):1002-14
Bostelman LJ, et al.  (2007) Methylation of histone H3 lysine-79 by Dot1p plays multiple roles in the response to UV damage in Saccharomyces cerevisiae. DNA Repair (Amst) 6(3):383-95
Fingerman IM, et al.  (2007) A charge-based interaction between histone H4 and Dot1 is required for H3K79 methylation and telomere silencing: identification of a new trans-histone pathway. Genes Dev 21(16):2018-29
Grenon M, et al.  (2007) Docking onto chromatin via the Saccharomyces cerevisiae Rad9 Tudor domain. Yeast 24(2):105-19
Lui DY, et al.  (2006) Analysis of close stable homolog juxtaposition during meiosis in mutants of Saccharomyces cerevisiae. Genetics 173(3):1207-22
Giannattasio M, et al.  (2005) The DNA damage checkpoint response requires histone H2B ubiquitination by Rad6-Bre1 and H3 methylation by Dot1. J Biol Chem 280(11):9879-86
Katan-Khaykovich Y and Struhl K  (2005) Heterochromatin formation involves changes in histone modifications over multiple cell generations. EMBO J 24(12):2138-49
Pokholok DK, et al.  (2005) Genome-wide map of nucleosome acetylation and methylation in yeast. Cell 122(4):517-27
Sheldon KE, et al.  (2005) A Requirement for the Saccharomyces cerevisiae Paf1 complex in snoRNA 3' end formation. Mol Cell 20(2):225-36
Wysocki R, et al.  (2005) Role of Dot1-dependent histone H3 methylation in G1 and S phase DNA damage checkpoint functions of Rad9. Mol Cell Biol 25(19):8430-43
Jacobson SJ, et al.  (2004) Functional analyses of chromatin modifications in yeast. Methods Enzymol 377:3-55
Sawada K, et al.  (2004) Structure of the conserved core of the yeast Dot1p, a nucleosomal histone H3 lysine 79 methyltransferase. J Biol Chem 279(41):43296-306
Krogan NJ, et al.  (2003) The Paf1 complex is required for histone H3 methylation by COMPASS and Dot1p: linking transcriptional elongation to histone methylation. Mol Cell 11(3):721-9