CYS4/YGR155W Literature Guide Help

Other names published for CYS4: NHS5, STR4, VMA41, cystathionine beta-synthase CYS4, YGR155W

CYS4 - Function/Process (26)

ReferenceOther Genes Addressed
Hoose SA, et al.  (2012) A systematic analysis of cell cycle regulators in yeast reveals that most factors act independently of cell size to control initiation of division. PLoS Genet 8(3):e1002590
Singh S, et al.  (2011) Pre-steady-state kinetic analysis of enzyme-monitored turnover during cystathionine ?-synthase-catalyzed H(2)S generation. Biochemistry 50(3):419-25
Lodha PH, et al.  (2010) Residue N84 of Yeast Cystathionine beta-Synthase is a Determinant of Reaction Specificity. Biochim Biophys Acta 1804(7):1424-1431
Blank HM, et al.  (2009) Sulfur metabolism actively promotes initiation of cell division in yeast. PLoS One 4(11):e8018
Lodha PH, et al.  (2009) Investigation of residues Lys112, Glu136, His138, Gly247, Tyr248, and Asp249 in the active site of yeast cystathionine beta-synthase. Biochem Cell Biol 87(3):531-40
Quazi F and Aitken SM  (2009) Characterization of the S289A,D mutants of yeast cystathionine beta-synthase. Biochim Biophys Acta 1794(6):892-7
Singh S, et al.  (2009) Relative Contributions of Cystathionine {beta}-Synthase and {gamma}-Cystathionase to H2S Biogenesis via Alternative Trans-sulfuration Reactions. J Biol Chem 284(33):22457-66
Linderholm AL, et al.  (2008) Identification of genes affecting hydrogen sulfide formation in Saccharomyces cerevisiae. Appl Environ Microbiol 74(5):1418-27
Kim HS and Fay JC  (2007) Genetic variation in the cysteine biosynthesis pathway causes sensitivity to pharmacological compounds. Proc Natl Acad Sci U S A 104(49):19387-91
Aitken SM and Kirsch JF  (2004) Role of active-site residues Thr81, Ser82, Thr85, Gln157, and Tyr158 in yeast cystathionine beta-synthase catalysis and reaction specificity. Biochemistry 43(7):1963-71
Aitken SM and Kirsch JF  (2003) Kinetics of the yeast cystathionine beta-synthase forward and reverse reactions: continuous assays and the equilibrium constant for the reaction. Biochemistry 42(2):571-8
Dimmer KS, et al.  (2002) Genetic basis of mitochondrial function and morphology in Saccharomyces cerevisiae. Mol Biol Cell 13(3):847-53
Jakubowski H  (2002) The determination of homocysteine-thiolactone in biological samples. Anal Biochem 308(1):112-9
Jhee KH, et al.  (2002) Yeast cystathionine beta-synthase reacts with L-allothreonine, a non-natural substrate, and L-homocysteine to form a new amino acid, 3-methyl-L-cystathionine. Biochemistry 41(6):1828-35
Taoka S and Banerjee R  (2002) Stopped-flow kinetic analysis of the reaction catalyzed by the full-length yeast cystathionine beta-synthase. J Biol Chem 277(25):22421-5
Brenner C  (2000) A cultivated taste for yeast. Genome Biol 1(1):REVIEWS103
Hansen J and Johannesen PF  (2000) Cysteine is essential for transcriptional regulation of the sulfur assimilation genes in Saccharomyces cerevisiae. Mol Gen Genet 263(3):535-42
Jhee KH, et al.  (2000) Domain architecture of the heme-independent yeast cystathionine beta-synthase provides insights into mechanisms of catalysis and regulation. Biochemistry 39(34):10548-56
Jhee KH, et al.  (2000) Yeast cystathionine beta-synthase is a pyridoxal phosphate enzyme but, unlike the human enzyme, is not a heme protein. J Biol Chem 275(16):11541-4
Maclean KN, et al.  (2000) Transsulfuration in Saccharomyces cerevisiae is not dependent on heme: purification and characterization of recombinant yeast cystathionine beta-synthase. J Inorg Biochem 81(3):161-71
Patton EE, et al.  (2000) SCF(Met30)-mediated control of the transcriptional activator Met4 is required for the G(1)-S transition. EMBO J 19(7):1613-24
Ohmori S, et al.  (1999) Saccharomyces cerevisiae cultured under aerobic and anaerobic conditions: air-level oxygen stress and protection against stress. Biochim Biophys Acta 1472(3):587-94
Ono BI, et al.  (1999) Cysteine biosynthesis in Saccharomyces cerevisiae: a new outlook on pathway and regulation. Yeast 15(13):1365-75
Oluwatosin YE and Kane PM  (1997) Mutations in the CYS4 gene provide evidence for regulation of the yeast vacuolar H+-ATPase by oxidation and reduction in vivo. J Biol Chem 272(44):28149-57
Ono B, et al.  (1994) Purification and properties of Saccharomyces cerevisiae cystathionine beta-synthase. Yeast 10(3):333-9
Cherest H and Surdin-Kerjan Y  (1992) Genetic analysis of a new mutation conferring cysteine auxotrophy in Saccharomyces cerevisiae: updating of the sulfur metabolism pathway. Genetics 130(1):51-8