Other names published for KEX2: QDS1, VMA45, SRB1, kexin, yscF, YNL238W
KEX2 LITERATURE TOPICS
- Curated Literature
- Genetics/Cell Biology
- Cellular Location
- Function/Process
- Genetic Interactions
- Mutants/Phenotypes
- Regulation of
- Regulatory Role
- Nucleic Acid Information
- Gene Product Information
- Related Genes/Proteins
- Research Aids
- Genome-wide Analysis
- Other Topics
- Additional Information
KEX2 - Function/Process (64)
| Reference | Other Genes Addressed |
|---|---|
| Karunanithi S, et al. (2010) Shedding of the Mucin-Like Flocculin Flo11p Reveals a New Aspect of Fungal Adhesion Regulation. Curr Biol 20(15):1389-1395 | |
| Heiman MG, et al. (2007) The Golgi-resident protease Kex2 acts in conjunction with Prm1 to facilitate cell fusion during yeast mating. J Cell Biol 176(2):209-22 | |
| Zhao X, et al. (2007) A role for Lte1p (a low temperature essential protein involved in mitosis) in proprotein processing in the yeast secretory pathway. J Biol Chem 282(3):1670-8 | |
| Wachter A and Schwappach B (2005) The yeast CLC chloride channel is proteolytically processed by the furin-like protease Kex2p in the first extracellular loop. FEBS Lett 579(5):1149-53 | |
| Holyoak T, et al. (2004) Structural basis for differences in substrate selectivity in Kex2 and furin protein convertases. Biochemistry 43(9):2412-21 | |
| Podsiadlo P, et al. (2004) Furin inhibition by compounds of copper and zinc. J Biol Chem 279(35):36219-27 | |
| Ringe D, et al. (2004) Protein structure to function: insights from computation. Cell Mol Life Sci 61(4):387-92 | |
| Rockwell NC and Thorner JW (2004) The kindest cuts of all: crystal structures of Kex2 and furin reveal secrets of precursor processing. Trends Biochem Sci 29(2):80-7 | |
| Komiyama T, et al. (2003) Optimization of protease-inhibitor interactions by randomizing adventitious contacts. Proc Natl Acad Sci U S A 100(14):8205-10 | |
| Lee J, et al. (2003) The influence of glycosylation on secretion, stability, and immunogenicity of recombinant HBV pre-S antigen synthesized in Saccharomyces cerevisiae. Biochem Biophys Res Commun 303(2):427-32 | |
| Lesage G, et al. (2003) trans-Complementation assay establishes the role of proregion hydrophobic amino acid residues in the biosynthesis of Saccharomyces cerevisiae Kex2p endoprotease. Yeast 20(5):397-406 | |
| Tomishige N, et al. (2003) Mutations that are synthetically lethal with a gas1Delta allele cause defects in the cell wall of Saccharomyces cerevisiae. Mol Genet Genomics 269(4):562-73 | |
| Kim SY, et al. (2002) Detection of site-specific proteolysis in secretory pathways. Biochem Biophys Res Commun 296(2):419-24 | |
| Riffer F, et al. (2002) Mutational analysis of K28 preprotoxin processing in the yeast Saccharomyces cerevisiae. Microbiology 148(Pt 5):1317-28 | |
| Rockwell NC and Fuller RS (2002) Specific modulation of Kex2/furin family proteases by potassium. J Biol Chem 277(20):17531-7 | |
| Rockwell NC, et al. (2002) Precursor processing by kex2/furin proteases. Chem Rev 102(12):4525-48 | |
| Roelants FM, et al. (2002) Pkh1 and Pkh2 differentially phosphorylate and activate Ypk1 and Ykr2 and define protein kinase modules required for maintenance of cell wall integrity. Mol Biol Cell 13(9):3005-28 | |
| Bensen ES, et al. (2001) Ric1p and the Ypt6p GTPase function in a common pathway required for localization of trans-Golgi network membrane proteins. Mol Biol Cell 12(1):13-26 | |
| Lesage G, et al. (2001) Mechanism of Kex2p inhibition by its proregion. FEBS Lett 508(3):332-6 | |
| Oda K, et al. (2001) Cloning and rational mutagenesis of kexstatin I, a potent proteinaceous inhibitor of Kex2 proteinase. Biochem J 355(Pt 2):339-46 | |
| Rockwell NC and Fuller RS (2001) Differential utilization of enzyme-substrate interactions for acylation but not deacylation during the catalytic cycle of Kex2 protease. J Biol Chem 276(42):38394-9 | |
| Rockwell NC and Fuller RS (2001) Direct measurement of acylenzyme hydrolysis demonstrates rate-limiting deacylation in cleavage of physiological sequences by the processing protease Kex2. Biochemistry 40(12):3657-65 | |
| Brigance WT, et al. (2000) Organization of the yeast Golgi complex into at least four functionally distinct compartments. Mol Biol Cell 11(1):171-82 | |
| Komiyama T and Fuller RS (2000) Engineered eglin c variants inhibit yeast and human proprotein processing proteases, Kex2 and furin. Biochemistry 39(49):15156-65 | |
| Lesage G, et al. (2000) The Kex2p proregion is essential for the biosynthesis of an active enzyme and requires a C-terminal basic residue for its function. Mol Biol Cell 11(6):1947-57 | |
| Lewis MJ, et al. (2000) Specific retrieval of the exocytic SNARE Snc1p from early yeast endosomes. Mol Biol Cell 11(1):23-38 | |
| Suzuki Y, et al. (2000) Effect of amino acid substitution at the P(3) and P(4) subsites of fusion proteins on kex2 protease activity. Biotechnol Appl Biochem 32 ( Pt 1):53-60 | |
| Henkel MK, et al. (1999) Endocytic delivery of intramolecularly quenched substrates and inhibitors to the intracellular yeast Kex2 protease1. Biochem J 341 ( Pt 2)():445-52 | |
| Moukadiri I, et al. (1999) Identification of two mannoproteins released from cell walls of a Saccharomyces cerevisiae mnn1 mnn9 double mutant by reducing agents. J Bacteriol 181(16):4741-5 | |
| Rehling P, et al. (1999) Formation of AP-3 transport intermediates requires Vps41 function. Nat Cell Biol 1(6):346-53 |



