MEC3/YLR288C Literature Guide Help

Other names published for MEC3: PIP3, PSO9, YLR288C

MEC3 - Function/Process (51)

ReferenceOther Genes Addressed
Collura A, et al.  (2012) Abasic sites linked to dUTP incorporation in DNA are a major cause of spontaneous mutations in absence of base excision repair and Rad17-Mec3-Ddc1 (9-1-1) DNA damage checkpoint clamp in Saccharomyces cerevisiae. DNA Repair (Amst) 11(3):294-303
Schmidt KH, et al.  (2010) Formation of complex and unstable chromosomal translocations in yeast.LID - e12007 [pii] PLoS One 5(8)
Navadgi-Patil VM and Burgers PM  (2008) Yeast DNA Replication Protein Dpb11 Activates the Mec1/ATR Checkpoint Kinase. J Biol Chem 283(51):35853-9
Razidlo DF and Lahue RS  (2008) Mrc1, Tof1 and Csm3 inhibit CAG.CTG repeat instability by at least two mechanisms. DNA Repair (Amst) 7(4):633-40
Grandin N and Charbonneau M  (2007) Control of the yeast telomeric senescence survival pathways of recombination by the Mec1 and Mec3 DNA damage sensors and RPA. Nucleic Acids Res 35(3):822-38
Ogiwara H, et al.  (2006) Dpb11, the budding yeast homolog of TopBP1, functions with the checkpoint clamp in recombination repair. Nucleic Acids Res 34(11):3389-98
Huang ME and Kolodner RD  (2005) A biological network in Saccharomyces cerevisiae prevents the deleterious effects of endogenous oxidative DNA damage. Mol Cell 17(5):709-20
Majka J and Burgers PM  (2005) Function of Rad17/Mec3/Ddc1 and its partial complexes in the DNA damage checkpoint. DNA Repair (Amst) 4(10):1189-94
Sabbioneda S, et al.  (2005) The 9-1-1 checkpoint clamp physically interacts with polzeta and is partially required for spontaneous polzeta-dependent mutagenesis in Saccharomyces cerevisiae. J Biol Chem 280(46):38657-65
Baroni E, et al.  (2004) The functions of budding yeast Sae2 in the DNA damage response require Mec1- and Tel1-dependent phosphorylation. Mol Cell Biol 24(10):4151-65
Jia X, et al.  (2004) Mec1 and Rad53 inhibit formation of single-stranded DNA at telomeres of Saccharomyces cerevisiae cdc13-1 mutants. Genetics 166(2):753-64
Lin J, et al.  (2004) Mutant telomere sequences lead to impaired chromosome separation and a unique checkpoint response. Mol Biol Cell 15(4):1623-34
Brendel M, et al.  (2003) Role of PSO genes in repair of DNA damage of Saccharomyces cerevisiae. Mutat Res 544(2-3):179-93
Giannattasio M, et al.  (2003) Correlation between checkpoint activation and in vivo assembly of the yeast checkpoint complex Rad17-Mec3-Ddc1. J Biol Chem 278(25):22303-8
King WR, et al.  (2003) Ionizing irradiation effects on S-phase in checkpoint mutants of the yeast Saccharomyces cerevisiae. Curr Genet 42(6):313-21
Majka J and Burgers PM  (2003) Yeast Rad17/Mec3/Ddc1: a sliding clamp for the DNA damage checkpoint. Proc Natl Acad Sci U S A 100(5):2249-54
Mieczkowski PA, et al.  (2003) Genetic regulation of telomere-telomere fusions in the yeast Saccharomyces cerevisae. Proc Natl Acad Sci U S A 100(19):10854-9
Enomoto S, et al.  (2002) MEC3, MEC1, and DDC2 are essential components of a telomere checkpoint pathway required for cell cycle arrest during senescence in Saccharomyces cerevisiae. Mol Biol Cell 13(8):2626-38
Giannattasio M, et al.  (2002) A dominant-negative MEC3 mutant uncovers new functions for the Rad17 complex and Tel1. Proc Natl Acad Sci U S A 99(20):12997-3002
Maringele L and Lydall D  (2002) EXO1-dependent single-stranded DNA at telomeres activates subsets of DNA damage and spindle checkpoint pathways in budding yeast yku70Delta mutants. Genes Dev 16(15):1919-33
Venclovas C, et al.  (2002) Molecular modeling-based analysis of interactions in the RFC-dependent clamp-loading process. Protein Sci 11(10):2403-16
Wang H and Elledge SJ  (2002) Genetic and physical interactions between DPB11 and DDC1 in the yeast DNA damage response pathway. Genetics 160(4):1295-304
Grandin N, et al.  (2001) Cdc13 prevents telomere uncapping and Rad50-dependent homologous recombination. EMBO J 20(21):6127-39
Klein HL  (2001) Mutations in recombinational repair and in checkpoint control genes suppress the lethal combination of srs2Delta with other DNA repair genes in Saccharomyces cerevisiae. Genetics 157(2):557-65
Melo JA, et al.  (2001) Two checkpoint complexes are independently recruited to sites of DNA damage in vivo. Genes Dev 15(21):2809-21
Myung K, et al.  (2001) Suppression of spontaneous chromosomal rearrangements by S phase checkpoint functions in Saccharomyces cerevisiae. Cell 104(3):397-408
Schramke V, et al.  (2001) The set1Delta mutation unveils a novel signaling pathway relayed by the Rad53-dependent hyperphosphorylation of replication protein A that leads to transcriptional activation of repair genes. Genes Dev 15(14):1845-58
Zhang H, et al.  (2001) Characterization of DNA damage-stimulated self-interaction of Saccharomyces cerevisiae checkpoint protein Rad17p. J Biol Chem 276(28):26715-23
Clarke DJ and Gimenez-Abian JF  (2000) Checkpoints controlling mitosis. Bioessays 22(4):351-63
Foiani M, et al.  (2000) DNA damage checkpoints and DNA replication controls in Saccharomyces cerevisiae. Mutat Res 451(1-2):187-96