ERG9/YHR190W Literature Guide Help

Other names published for ERG9: bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase, YHR190W

ERG9 - Function/Process (24)

ReferenceOther Genes Addressed
Lenihan JR, et al.  (2008) Developing an industrial artemisinic acid fermentation process to support the cost-effective production of antimalarial artemisinin-based combination therapies. Biotechnol Prog 24(5):1026-32
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Hongay C, et al.  (2002) Mot3 is a transcriptional repressor of ergosterol biosynthetic genes and is required for normal vacuolar function in Saccharomyces cerevisiae. EMBO J 21(15):4114-24
Kennedy MA and Bard M  (2001) Positive and negative regulation of squalene synthase (ERG9), an ergosterol biosynthetic gene, in Saccharomyces cerevisiae. Biochim Biophys Acta 1517(2):177-89
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Merkulov S, et al.  (2000) Cloning and characterization of the Yarrowia lipolytica squalene synthase (SQS1) gene and functional complementation of the Saccharomyces cerevisiae erg9 mutation. Yeast 16(3):197-206
Radisky ES and Poulter CD  (2000) Squalene synthase: steady-state, pre-steady-state, and isotope-trapping studies. Biochemistry 39(7):1748-60
Kalinowski SS and Mookhtiar KA  (1999) Mechanism of inhibition of yeast squalene synthase by substrate analog inhibitors. Arch Biochem Biophys 368(2):338-46
Hanley KM, et al.  (1996) Molecular cloning, in vitro expression and characterization of a plant squalene synthetase cDNA. Plant Mol Biol 30(6):1139-51
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Mookhtiar KA, et al.  (1994) Yeast squalene synthase. A mechanism for addition of substrates and activation by NADPH. J Biol Chem 269(15):11201-7
Robinson GW, et al.  (1993) Conservation between human and fungal squalene synthetases: similarities in structure, function, and regulation. Mol Cell Biol 13(5):2706-17
Szkopinska A, et al.  (1993) The deficiency of sterol biosynthesis in Saccharomyces cerevisiae affects the synthesis of glycosyl derivatives of dolichyl phosphates. FEMS Microbiol Lett 112(3):325-8
Zhang D, et al.  (1993) Yeast squalene synthase: expression, purification, and characterization of soluble recombinant enzyme. Arch Biochem Biophys 304(1):133-43
Fegueur M, et al.  (1991) Isolation and primary structure of the ERG9 gene of Saccharomyces cerevisiae encoding squalene synthetase. Curr Genet 20(5):365-72
Jennings SM, et al.  (1991) Molecular cloning and characterization of the yeast gene for squalene synthetase. Proc Natl Acad Sci U S A 88(14):6038-42
Kuswik-Rabiega G and Rilling HC  (1987) Squalene synthetase. Solubilization and partial purification of squalene synthetase, copurification of presqualene pyrophosphate and squalene synthetase activities. J Biol Chem 262(4):1505-9
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Agnew WS and Popjak G  (1978) Squalene synthetase. Solubilization from yeast microsomes of a phospholipid-requiring enzyme. J Biol Chem 253(13):4574-83
Agnew WS and Popjak G  (1978) Squalene synthetase. Stoichiometry and kinetics of presqualene pyrophosphate and squalene synthesis by yeast microsomes. J Biol Chem 253(13):4566-73
Karst F and Lacroute F  (1977) Ertosterol biosynthesis in Saccharomyces cerevisiae: mutants deficient in the early steps of the pathway. Mol Gen Genet 154(3):269-77
Ortiz de Montellano PR, et al.  (1977) Substrate selectivity of squalene synthetase. Biochemistry 16(12):2680-5
Katsuki H and Bloch K  (1967) Studies on the biosynthesis of ergosterol in yeast. Formation of methylated intermediates. J Biol Chem 242(2):222-7