IRA2/YOL081W Literature Guide Help

Other names published for IRA2: CCS1, GLC4, YOL081W

IRA2 - Disease Gene Related (7)

ReferenceOther Genes Addressed
Wood M, et al.  (2011) Discovery of a small molecule targeting IRA2 deletion in budding yeast and neurofibromin loss in malignant peripheral nerve sheath tumor cells. Mol Cancer Ther 10(9):1740-50
Phan VT, et al.  (2010) The RasGAP proteins Ira2 and neurofibromin are negatively regulated by Gpb1 in yeast and ETEA in humans. Mol Cell Biol 30(9):2264-79
Wood MD and Sanchez Y  (2010) Deregulated Ras signaling compromises DNA damage checkpoint recovery in S. cerevisiae. Cell Cycle 9(16):3353-63
Nakafuku M, et al.  (1993) Suppression of oncogenic Ras by mutant neurofibromatosis type 1 genes with single amino acid substitutions. Proc Natl Acad Sci U S A 90(14):6706-10
Ballester R, et al.  (1990) The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins. Cell 63(4):851-9
Buchberg AM, et al.  (1990) Sequence homology shared by neurofibromatosis type-1 gene and IRA-1 and IRA-2 negative regulators of the RAS cyclic AMP pathway. Nature 347(6290):291-4
Xu GF, et al.  (1990) The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae. Cell 63(4):835-41