GCN4/YEL009C Literature Guide Help

Other names published for GCN4: AAS3, ARG9, AAS101, YEL009C

GCN4 - DNA/RNA Sequence Features (46)

ReferenceOther Genes Addressed
Munzarova V, et al.  (2011) Translation Reinitiation Relies on the Interaction between eIF3a/TIF32 and Progressively Folded cis-Acting mRNA Elements Preceding Short uORFs. PLoS Genet 7(7):e1002137
Zhang F and Hinnebusch AG  (2011) An upstream ORF with non-AUG start codon is translated in vivo but dispensable for translational control of GCN4 mRNA. Nucleic Acids Res 39(8):3128-40
Cuchalova L, et al.  (2010) The RNA Recognition Motif of Eukaryotic Translation Initiation Factor 3g (eIF3g) Is Required for Resumption of Scanning of Posttermination Ribosomes for Reinitiation on GCN4 and Together with eIF3i Stimulates Linear Scanning. Mol Cell Biol 30(19):4671-86
Nikolaev Y, et al.  (2010) The Leucine Zipper Domains of the Transcription Factors GCN4 and c-Jun Have Ribonuclease Activity. PLoS One 5(5):e10765
Roy B, et al.  (2010) The h subunit of eIF3 promotes reinitiation competence during translation of mRNAs harboring upstream open reading frames. RNA 16(4):748-61
Hood HM, et al.  (2009) Evolutionary roles of upstream open reading frames in mediating gene regulation in fungi. Annu Rev Microbiol 63:385-409
Shirra MK, et al.  (2008) A Chemical Genomics Study Identifies Snf1 as a Repressor of GCN4 Translation. J Biol Chem 283(51):35889-98
Szamecz B, et al.  (2008) eIF3a cooperates with sequences 5' of uORF1 to promote resumption of scanning by post-termination ribosomes for reinitiation on GCN4 mRNA. Genes Dev 22(17):2414-25
Cvijovic M, et al.  (2007) Identification of putative regulatory upstream ORFs in the yeast genome using heuristics and evolutionary conservation. BMC Bioinformatics 8:295
Martin-Marcos P, et al.  (2007) Ribosomal protein L33 is required for ribosome biogenesis, subunit joining, and repression of GCN4 translation. Mol Cell Biol 27(17):5968-85
Seong KM, et al.  (2007) A new method for the construction of a mutant library with a predictable occurrence rate using Poisson distribution. J Microbiol Methods 69(3):442-50
Zhang Z and Dietrich FS  (2005) Identification and characterization of upstream open reading frames (uORF) in the 5' untranslated regions (UTR) of genes in Saccharomyces cerevisiae. Curr Genet 48(2):77-87
Vilela C and McCarthy JE  (2003) Regulation of fungal gene expression via short open reading frames in the mRNA 5'untranslated region. Mol Microbiol 49(4):859-67
Morillon A, et al.  (2002) Differential effects of chromatin and Gcn4 on the 50-fold range of expression among individual yeast Ty1 retrotransposons. Mol Cell Biol 22(7):2078-88
Gaba A, et al.  (2001) Physical evidence for distinct mechanisms of translational control by upstream open reading frames. EMBO J 20(22):6453-63
Mimran A, et al.  (2000) GCN4-based expression system (pGES): translationally regulated yeast expression vectors. Biotechniques 28(3):552-4, 556, 558-60
Ruiz-Echevarria MJ and Peltz SW  (2000) The RNA binding protein Pub1 modulates the stability of transcripts containing upstream open reading frames. Cell 101(7):741-51
Duvel K and Braus GH  (1999) Different positioning elements select poly(A) sites at the 3'-end of GCN4 mRNA in the yeast Saccharomyces cerevisiae. Nucleic Acids Res 27(24):4751-8
Vilela C, et al.  (1999) Post-termination ribosome interactions with the 5'UTR modulate yeast mRNA stability. EMBO J 18(11):3139-52
Cuesta R, et al.  (1998) Identification of GCD14 and GCD15, novel genes required for translational repression of GCN4 mRNA in Saccharomyces cerevisiae. Genetics 148(3):1007-20
Ruiz-Echevarria MJ, et al.  (1998) Identifying the right stop: determining how the surveillance complex recognizes and degrades an aberrant mRNA. EMBO J 17(2):575-89
Ruiz-Echevarria MJ and Peltz SW  (1996) Utilizing the GCN4 leader region to investigate the role of the sequence determinants in nonsense-mediated mRNA decay. EMBO J 15(11):2810-9
Dever TE, et al.  (1995) Modulation of tRNA(iMet), eIF-2, and eIF-2B expression shows that GCN4 translation is inversely coupled to the level of eIF-2.GTP.Met-tRNA(iMet) ternary complexes. Mol Cell Biol 15(11):6351-63
Egli CM, et al.  (1995) A complex unidirectional signal element mediates GCN4 mRNA 3' end formation in Saccharomyces cerevisiae. Mol Cell Biol 15(5):2466-73
Grant CM, et al.  (1995) Sequences 5' of the first upstream open reading frame in GCN4 mRNA are required for efficient translational reinitiation. Nucleic Acids Res 23(19):3980-8
Grant CM and Hinnebusch AG  (1994) Effect of sequence context at stop codons on efficiency of reinitiation in GCN4 translational control. Mol Cell Biol 14(1):606-18
Grant CM, et al.  (1994) Requirements for intercistronic distance and level of eukaryotic initiation factor 2 activity in reinitiation on GCN4 mRNA vary with the downstream cistron. Mol Cell Biol 14(4):2616-28
Bushman JL, et al.  (1993) Evidence that GCD6 and GCD7, translational regulators of GCN4, are subunits of the guanine nucleotide exchange factor for eIF-2 in Saccharomyces cerevisiae. Mol Cell Biol 13(3):1920-32
Rolfes RJ and Hinnebusch AG  (1993) Translation of the yeast transcriptional activator GCN4 is stimulated by purine limitation: implications for activation of the protein kinase GCN2. Mol Cell Biol 13(8):5099-111
Abastado JP, et al.  (1991) A quantitative model for translational control of the GCN4 gene of Saccharomyces cerevisiae. New Biol 3(5):511-24