SIR4/YDR227W Literature Guide Help

Other names published for SIR4: ASD1, STE9, UTH2, YDR227W

SIR4 - Cellular Location (31)

ReferenceOther Genes Addressed
Burgess RJ, et al.  (2012) The SCF(Dia2) Ubiquitin E3 Ligase Ubiquitylates Sir4 and Functions in Transcriptional Silencing. PLoS Genet 8(7):e1002846
Nagesh P, et al.  (2012) The SUMO E3 ligase Siz2 exerts a locus-dependent effect on gene silencing in Saccharomyces cerevisiae. Eukaryot Cell 11(4):452-62
Dubarry M, et al.  (2011) Tight protein-DNA interactions favor gene silencing. Genes Dev 25(13):1365-70
Kitada T, et al.  (2011) gammaH2A is a component of yeast heterochromatin required for telomere elongation. Cell Cycle 10(2):293-300
Leung A, et al.  (2011) Histone H2B ubiquitylation and H3 lysine 4 methylation prevent ectopic silencing of euchromatic loci important for the cellular response to heat. Mol Biol Cell 22(15):2741-53
Oppikofer M, et al.  (2011) A dual role of H4K16 acetylation in the establishment of yeast silent chromatin.LID - 10.1038/emboj.2011.170 [doi] EMBO J ()
Wan Y, et al.  (2010) Histone chaperone Chz1p regulates H2B ubiquitination and subtelomeric anti-silencing. Nucleic Acids Res 38(5):1431-40
Taddei A, et al.  (2009) The functional importance of telomere clustering: Global changes in gene expression result from SIR factor dispersion. Genome Res 19(4):611-25
Patterson EE and Fox CA  (2008) The Ku Complex in Silencing the Cryptic Mating-Type Loci of Saccharomyces cerevisiae. Genetics 180(2):771-83
Bupp JM, et al.  (2007) Telomere anchoring at the nuclear periphery requires the budding yeast Sad1-UNC-84 domain protein Mps3. J Cell Biol 179(5):845-54
Huang S, et al.  (2007) A novel role for histone chaperones CAF-1 and Rtt106p in heterochromatin silencing. EMBO J 26(9):2274-83
Yang B and Kirchmaier AL  (2006) Bypassing the Catalytic Activity of SIR2 for SIR Protein Spreading in Saccharomyces cerevisiae. Mol Biol Cell 17(12):5287-97
Zhou H, et al.  (2006) Chromatin assembly factor 1 interacts with histone H3 methylated at lysine 79 in the processes of epigenetic silencing and DNA repair. Biochemistry 45(9):2852-61
Taddei A, et al.  (2005) Multiple pathways tether telomeres and silent chromatin at the nuclear periphery: functional implications for sir-mediated repression. Novartis Found Symp 264:140-56; discussion 156-65, 227-30
Taddei A, et al.  (2004) Separation of silencing from perinuclear anchoring functions in yeast Ku80, Sir4 and Esc1 proteins. EMBO J 23(6):1301-12
Luo K, et al.  (2002) Rap1-Sir4 binding independent of other Sir, yKu, or histone interactions initiates the assembly of telomeric heterochromatin in yeast. Genes Dev 16(12):1528-39
Rusche LN, et al.  (2002) Ordered nucleation and spreading of silenced chromatin in Saccharomyces cerevisiae. Mol Biol Cell 13(7):2207-22
Zhang Z, et al.  (2002) Structure and function of the BAH-containing domain of Orc1p in epigenetic silencing. EMBO J 21(17):4600-11
Laroche T, et al.  (2000) The dynamics of yeast telomeres and silencing proteins through the cell cycle. J Struct Biol 129(2-3):159-74
Mills KD, et al.  (1999) MEC1-dependent redistribution of the Sir3 silencing protein from telomeres to DNA double-strand breaks. Cell 97(5):609-20
Bourns BD, et al.  (1998) Sir proteins, Rif proteins, and Cdc13p bind Saccharomyces telomeres in vivo. Mol Cell Biol 18(9):5600-8
Cockell M, et al.  (1998) Sif2p interacts with Sir4p amino-terminal domain and antagonizes telomeric silencing in yeast. Curr Biol 8(13):787-90
Laroche T, et al.  (1998) Mutation of yeast Ku genes disrupts the subnuclear organization of telomeres. Curr Biol 8(11):653-6
Ansari A and Gartenberg MR  (1997) The yeast silent information regulator Sir4p anchors and partitions plasmids. Mol Cell Biol 17(12):7061-8
Gotta M, et al.  (1997) Localization of Sir2p: the nucleolus as a compartment for silent information regulators. EMBO J 16(11):3243-55
Kennedy BK, et al.  (1997) Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae. Cell 89(3):381-91
Strahl-Bolsinger S, et al.  (1997) SIR2 and SIR4 interactions differ in core and extended telomeric heterochromatin in yeast. Genes Dev 11(1):83-93
Gotta M, et al.  (1996) The clustering of telomeres and colocalization with Rap1, Sir3, and Sir4 proteins in wild-type Saccharomyces cerevisiae. J Cell Biol 134(6):1349-63
Cockell M, et al.  (1995) The carboxy termini of Sir4 and Rap1 affect Sir3 localization: evidence for a multicomponent complex required for yeast telomeric silencing. J Cell Biol 129(4):909-24
Palladino F, et al.  (1993) SIR3 and SIR4 proteins are required for the positioning and integrity of yeast telomeres. Cell 75(3):543-55