MEC1/YBR136W Literature Guide Help

Other names published for MEC1: ESR1, SAD3, RAD31, YBR136W

MEC1 - Cell Cycle Phase Involved (70)

ReferenceOther Genes Addressed
Feng W, et al.  (2011) Replication stress-induced chromosome breakage is correlated with replication fork progression and is preceded by single-stranded DNA formation. G3 (Bethesda) 1(5):327-35
Jones MH, et al.  (2011) Cell cycle phosphorylation of mitotic exit network (MEN) proteins. Cell Cycle 10(20):3435-40
Weinberger M, et al.  (2010) Growth signaling promotes chronological aging in budding yeast by inducing superoxide anions that inhibit quiescence. Aging (Albany NY) 2(10):709-26
Friedel AM, et al.  (2009) ATR/Mec1: coordinating fork stability and repair. Curr Opin Cell Biol 21(2):237-44
Navadgi-Patil VM and Burgers PM  (2009) The Unstructured C-Terminal Tail of the 9-1-1 Clamp Subunit Ddc1 Activates Mec1/ATR via Two Distinct Mechanisms. Mol Cell 36(5):743-753
di Domenico EG, et al.  (2009) The Mec1p and Tel1p checkpoint kinases allow humanized yeast to tolerate chronic telomere dysfunctions by suppressing telomere fusions. DNA Repair (Amst) 8(2):209-18
Kim EM and Burke DJ  (2008) DNA damage activates the SAC in an ATM/ATR-dependent manner, independently of the kinetochore. PLoS Genet 4(2):e1000015
Dotiwala F, et al.  (2007) The yeast DNA damage checkpoint proteins control a cytoplasmic response to DNA damage. Proc Natl Acad Sci U S A 104(27):11358-63
Lebedeva MA and Shadel GS  (2007) Cell cycle- and ribonucleotide reductase-driven changes in mtDNA copy number influence mtDNA Inheritance without compromising mitochondrial gene expression. Cell Cycle 6(16):2048-57
Sun M and Fasullo M  (2007) Activation of the budding yeast securin Pds1 but not Rad53 correlates with double-strand break-associated G2/M cell cycle arrest in a mec1 hypomorphic mutant. Cell Cycle 6(15):1896-902
Cartagena-Lirola H, et al.  (2006) Budding Yeast Sae2 is an In Vivo Target of the Mec1 and Tel1 Checkpoint Kinases During Meiosis. Cell Cycle 5(14):1549-59
Goudsouzian LK, et al.  (2006) S. cerevisiae Tel1p and Mre11p are required for normal levels of Est1p and Est2p telomere association. Mol Cell 24(4):603-10
Grenon M, et al.  (2006) Double-strand breaks trigger MRX- and Mec1-dependent, but Tel1-independent, checkpoint activation. FEMS Yeast Res 6(5):836-47
Menacho-Marquez M and Murguia JR  (2006) Beta-lapachone activates a Mre11p-Tel1p G1/S checkpoint in budding yeast. Cell Cycle 5(21):2509-16
Carter CD, et al.  (2005) Loss of SOD1 and LYS7 sensitizes Saccharomyces cerevisiae to hydroxyurea and DNA damage agents and downregulates MEC1 pathway effectors. Mol Cell Biol 25(23):10273-85
Chakhparonian M, et al.  (2005) A mutation in yeast Tel1p that causes differential effects on the DNA damage checkpoint and telomere maintenance. Curr Genet 48(5):310-22
Clerici M, et al.  (2004) A Tel1/MRX-dependent checkpoint inhibits the metaphase-to-anaphase transition after UV irradiation in the absence of Mec1. Mol Cell Biol 24(23):10126-44
Ira G, et al.  (2004) DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1. Nature 431(7011):1011-7
Lee SJ, et al.  (2004) A Ddc2-Rad53 fusion protein can bypass the requirements for RAD9 and MRC1 in Rad53 activation. Mol Biol Cell 15(12):5443-55
Searle JS, et al.  (2004) The DNA damage checkpoint and PKA pathways converge on APC substrates and Cdc20 to regulate mitotic progression. Nat Cell Biol 6(2):138-45
Takata H, et al.  (2004) Reciprocal association of the budding yeast ATM-related proteins Tel1 and Mec1 with telomeres in vivo. Mol Cell 14(4):515-22
Clarke DJ, et al.  (2003) S-phase checkpoint controls mitosis via an APC-independent Cdc20p function. Nat Cell Biol 5(10):928-35
Jiang YW and Kang CM  (2003) Induction of S. cerevisiae filamentous differentiation by slowed DNA synthesis involves Mec1, Rad53 and Swe1 checkpoint proteins. Mol Biol Cell 14(12):5116-24
Tercero JA, et al.  (2003) A central role for DNA replication forks in checkpoint activation and response. Mol Cell 11(5):1323-36
Cha RS and Kleckner N  (2002) ATR homolog Mec1 promotes fork progression, thus averting breaks in replication slow zones. Science 297(5581):602-6
Giannattasio M, et al.  (2002) A dominant-negative MEC3 mutant uncovers new functions for the Rad17 complex and Tel1. Proc Natl Acad Sci U S A 99(20):12997-3002
Vaze MB, et al.  (2002) Recovery from checkpoint-mediated arrest after repair of a double-strand break requires Srs2 helicase. Mol Cell 10(2):373-85
Clarke DJ, et al.  (2001) Mec1p regulates Pds1p levels in S phase: complex coordination of DNA replication and mitosis. Nat Cell Biol 3(7):619-27
Clerici M, et al.  (2001) Hyperactivation of the yeast DNA damage checkpoint by TEL1 and DDC2 overexpression. EMBO J 20(22):6485-98
Foss EJ  (2001) Tof1p regulates DNA damage responses during S phase in Saccharomyces cerevisiae. Genetics 157(2):567-77