Other names published for MEC1: ESR1, SAD3, RAD31, YBR136W
MEC1 LITERATURE TOPICS
- Curated Literature
- Genetics/Cell Biology
- Cell Cycle Phase Involved
- Cell Growth and Metabolism
- Cellular Location
- Function/Process
- Genetic Interactions
- Mutants/Phenotypes
- Regulation of
- Regulatory Role
- Nucleic Acid Information
- Gene Product Information
- Related Genes/Proteins
- Research Aids
- Genome-wide Analysis
- Proteome-wide Analysis
- Other Topics
- Additional Information
MEC1 - Cell Cycle Phase Involved (70)
| Reference | Other Genes Addressed |
|---|---|
| Feng W, et al. (2011) Replication stress-induced chromosome breakage is correlated with replication fork progression and is preceded by single-stranded DNA formation. G3 (Bethesda) 1(5):327-35 | |
| Jones MH, et al. (2011) Cell cycle phosphorylation of mitotic exit network (MEN) proteins. Cell Cycle 10(20):3435-40 | |
| Weinberger M, et al. (2010) Growth signaling promotes chronological aging in budding yeast by inducing superoxide anions that inhibit quiescence. Aging (Albany NY) 2(10):709-26 | |
| Friedel AM, et al. (2009) ATR/Mec1: coordinating fork stability and repair. Curr Opin Cell Biol 21(2):237-44 | |
| Navadgi-Patil VM and Burgers PM (2009) The Unstructured C-Terminal Tail of the 9-1-1 Clamp Subunit Ddc1 Activates Mec1/ATR via Two Distinct Mechanisms. Mol Cell 36(5):743-753 | |
| di Domenico EG, et al. (2009) The Mec1p and Tel1p checkpoint kinases allow humanized yeast to tolerate chronic telomere dysfunctions by suppressing telomere fusions. DNA Repair (Amst) 8(2):209-18 | |
| Kim EM and Burke DJ (2008) DNA damage activates the SAC in an ATM/ATR-dependent manner, independently of the kinetochore. PLoS Genet 4(2):e1000015 | |
| Dotiwala F, et al. (2007) The yeast DNA damage checkpoint proteins control a cytoplasmic response to DNA damage. Proc Natl Acad Sci U S A 104(27):11358-63 | |
| Lebedeva MA and Shadel GS (2007) Cell cycle- and ribonucleotide reductase-driven changes in mtDNA copy number influence mtDNA Inheritance without compromising mitochondrial gene expression. Cell Cycle 6(16):2048-57 | |
| Sun M and Fasullo M (2007) Activation of the budding yeast securin Pds1 but not Rad53 correlates with double-strand break-associated G2/M cell cycle arrest in a mec1 hypomorphic mutant. Cell Cycle 6(15):1896-902 | |
| Cartagena-Lirola H, et al. (2006) Budding Yeast Sae2 is an In Vivo Target of the Mec1 and Tel1 Checkpoint Kinases During Meiosis. Cell Cycle 5(14):1549-59 | |
| Goudsouzian LK, et al. (2006) S. cerevisiae Tel1p and Mre11p are required for normal levels of Est1p and Est2p telomere association. Mol Cell 24(4):603-10 | |
| Grenon M, et al. (2006) Double-strand breaks trigger MRX- and Mec1-dependent, but Tel1-independent, checkpoint activation. FEMS Yeast Res 6(5):836-47 | |
| Menacho-Marquez M and Murguia JR (2006) Beta-lapachone activates a Mre11p-Tel1p G1/S checkpoint in budding yeast. Cell Cycle 5(21):2509-16 | |
| Carter CD, et al. (2005) Loss of SOD1 and LYS7 sensitizes Saccharomyces cerevisiae to hydroxyurea and DNA damage agents and downregulates MEC1 pathway effectors. Mol Cell Biol 25(23):10273-85 | |
| Chakhparonian M, et al. (2005) A mutation in yeast Tel1p that causes differential effects on the DNA damage checkpoint and telomere maintenance. Curr Genet 48(5):310-22 | |
| Clerici M, et al. (2004) A Tel1/MRX-dependent checkpoint inhibits the metaphase-to-anaphase transition after UV irradiation in the absence of Mec1. Mol Cell Biol 24(23):10126-44 | |
| Ira G, et al. (2004) DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1. Nature 431(7011):1011-7 | |
| Lee SJ, et al. (2004) A Ddc2-Rad53 fusion protein can bypass the requirements for RAD9 and MRC1 in Rad53 activation. Mol Biol Cell 15(12):5443-55 | |
| Searle JS, et al. (2004) The DNA damage checkpoint and PKA pathways converge on APC substrates and Cdc20 to regulate mitotic progression. Nat Cell Biol 6(2):138-45 | |
| Takata H, et al. (2004) Reciprocal association of the budding yeast ATM-related proteins Tel1 and Mec1 with telomeres in vivo. Mol Cell 14(4):515-22 | |
| Clarke DJ, et al. (2003) S-phase checkpoint controls mitosis via an APC-independent Cdc20p function. Nat Cell Biol 5(10):928-35 | |
| Jiang YW and Kang CM (2003) Induction of S. cerevisiae filamentous differentiation by slowed DNA synthesis involves Mec1, Rad53 and Swe1 checkpoint proteins. Mol Biol Cell 14(12):5116-24 | |
| Tercero JA, et al. (2003) A central role for DNA replication forks in checkpoint activation and response. Mol Cell 11(5):1323-36 | |
| Cha RS and Kleckner N (2002) ATR homolog Mec1 promotes fork progression, thus averting breaks in replication slow zones. Science 297(5581):602-6 | |
| Giannattasio M, et al. (2002) A dominant-negative MEC3 mutant uncovers new functions for the Rad17 complex and Tel1. Proc Natl Acad Sci U S A 99(20):12997-3002 | |
| Vaze MB, et al. (2002) Recovery from checkpoint-mediated arrest after repair of a double-strand break requires Srs2 helicase. Mol Cell 10(2):373-85 | |
| Clarke DJ, et al. (2001) Mec1p regulates Pds1p levels in S phase: complex coordination of DNA replication and mitosis. Nat Cell Biol 3(7):619-27 | |
| Clerici M, et al. (2001) Hyperactivation of the yeast DNA damage checkpoint by TEL1 and DDC2 overexpression. EMBO J 20(22):6485-98 | |
| Foss EJ (2001) Tof1p regulates DNA damage responses during S phase in Saccharomyces cerevisiae. Genetics 157(2):567-77 |





