DRS1/YLL008W Additional Physico-chemical Properties Help

Physico-chemical properties were determined using the ProtParam tool available through ExPASy to analyze the primary protein sequence for atomic composition, extinction coefficient, estimated half-life, instability index and aliphatic index. Transcript translation calculations were determined using CodonW.


A.A. Composition
Ala[A] 48 6.4%
Arg[R] 47 6.2%
Asn[N] 35 4.7%
Asp[D] 57 7.6%
Cys[C] 1 0.1%
Gln[Q] 25 3.3%
Glu[E] 84 11.2%
Gly[G] 46 6.1%
His[H] 8 1.1%
Ile[I] 46 6.1%
Leu[L] 62 8.2%
Lys[K] 81 10.8%
Met[M] 20 2.7%
Phe[F] 24 3.2%
Pro[P] 23 3.1%
Ser[S] 52 6.9%
Thr[T] 34 4.5%
Trp[W] 3 0.4%
Tyr[Y] 9 1.2%
Val[V] 47 6.2%
Total Length 752

Instability index
Instability index (II) 48.93
This classifies the protein as unstable

Atomic composition
Carbon 3688
Hydrogen 6037
Nitrogen 1053
Oxygen 1190
Sulfur 21
Total number of atoms 11989
Formula = C3688H6037N1053O1190S21

Estimated half-life
Escherichia coli (in vivo) >10 hours
mammalian reticulocytes (in vitro) 30 hours
yeast (in vivo) >20 hours

Extinction Coefficients at 280 nm
assuming ALL Cys residues appear as half cystines 29910 M-1 cm-1
assuming NO Cys residues appear as half cystines 29910 M-1 cm-1
assuming all Cys residues are reduced 29910 M-1 cm-1
assuming all pairs of Cys residues form cystines 29910 M-1 cm-1

Aliphatic index
Aliphatic index 80.52

Coding Region Translation Calculations
Codon Bias 0.228
Codon Adaptation Index 0.227
Frequency of Optimal Codons 0.543
Hydropathicity of Protein -0.741
Aromaticity Score 0.048