TYR1/YBR166C Additional Physico-chemical Properties Help

Physico-chemical properties were determined using the ProtParam tool available through ExPASy to analyze the primary protein sequence for atomic composition, extinction coefficient, estimated half-life, instability index and aliphatic index. Transcript translation calculations were determined using CodonW.


A.A. Composition
Ala[A] 29 6.4%
Arg[R] 9 2.0%
Asn[N] 20 4.4%
Asp[D] 23 5.1%
Cys[C] 7 1.5%
Gln[Q] 17 3.8%
Glu[E] 29 6.4%
Gly[G] 25 5.5%
His[H] 13 2.9%
Ile[I] 37 8.2%
Leu[L] 43 9.5%
Lys[K] 37 8.2%
Met[M] 8 1.8%
Phe[F] 20 4.4%
Pro[P] 15 3.3%
Ser[S] 42 9.3%
Thr[T] 22 4.9%
Trp[W] 8 1.8%
Tyr[Y] 20 4.4%
Val[V] 28 6.2%
Total Length 452

Instability index
Instability index (II) 34.96
This classifies the protein as stable

Atomic composition
Carbon 2311
Hydrogen 3587
Nitrogen 587
Oxygen 678
Sulfur 15
Total number of atoms 7178
Formula = C2311H3587N587O678S15

Estimated half-life
Escherichia coli (in vivo) >10 hours
mammalian reticulocytes (in vitro) 30 hours
yeast (in vivo) >20 hours

Extinction Coefficients at 280 nm
assuming ALL Cys residues appear as half cystines 74175 M-1 cm-1
assuming NO Cys residues appear as half cystines 73800 M-1 cm-1
assuming all Cys residues are reduced 73800 M-1 cm-1
assuming all pairs of Cys residues form cystines 74175 M-1 cm-1

Aliphatic index
Aliphatic index 93.41

Coding Region Translation Calculations
Codon Bias 0.033
Codon Adaptation Index 0.145
Frequency of Optimal Codons 0.438
Hydropathicity of Protein -0.145
Aromaticity Score 0.106