TKL1/YPR074C Protein Information Help

TKL1 BASIC PROTEIN INFORMATION

Standard Name Tkl1p
Systematic Name Ypr074cp
ORF Classification Verified
Description Transketolase, similar to Tkl2p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids ( 1, 2 )
Name Description TransKetoLase
Experimental Data
Molecules/cell 40300 3
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 680
Molecular Weight (Da) 73,805
Isoelectric Point (pI) 7.01

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Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Tkl1p (InterPro)
Physical Interactions There are 17 total curated physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | PSI-BLAST | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
Secondary Structure Prediction GCG:PepPlot | GCG:PepStruct | GCG:Helical Wheel
External Sequence Databases EBI: P23254 | UPI0000052E92
MIPS: YPR074C
NCBI: NP_015399.1 | 6325331
GenBank/EMBL/DDBJ: M63302
External Classifications EC: 2.2.1.1 [Transketolase]
Amino Acid Sequence (or in FASTA format)
 
       1  MTQFTDIDKL AVSTIRILAV DTVSKANSGH PGAPLGMAPA AHVLWSQMRM
      51  NPTNPDWINR DRFVLSNGHA VALLYSMLHL TGYDLSIEDL KQFRQLGSRT
     101  PGHPEFELPG VEVTTGPLGQ GISNAVGMAM AQANLAATYN KPGFTLSDNY
     151  TYVFLGDGCL QEGISSEASS LAGHLKLGNL IAIYDDNKIT IDGATSISFD
     201  EDVAKRYEAY GWEVLYVENG NEDLAGIAKA IAQAKLSKDK PTLIKMTTTI
     251  GYGSLHAGSH SVHGAPLKAD DVKQLKSKFG FNPDKSFVVP QEVYDHYQKT
     301  ILKPGVEANN KWNKLFSEYQ KKFPELGAEL ARRLSGQLPA NWESKLPTYT
     351  AKDSAVATRK LSETVLEDVY NQLPELIGGS ADLTPSNLTR WKEALDFQPP
     401  SSGSGNYSGR YIRYGIREHA MGAIMNGISA FGANYKPYGG TFLNFVSYAA
     451  GAVRLSALSG HPVIWVATHD SIGVGEDGPT HQPIETLAHF RSLPNIQVWR
     501  PADGNEVSAA YKNSLESKHT PSIIALSRQN LPQLEGSSIE SASKGGYVLQ
     551  DVANPDIILV ATGSEVSLSV EAAKTLAAKN IKARVVSLPD FFTFDKQPLE
     601  YRLSVLPDNV PIMSVEVLAT TCWGKYAHQS FGIDRFGASG KAPEVFKFFG
     651  FTPEGVAERA QKTIAFYKGD KLISPLKKAF *

EXTERNAL LINKS for Tkl1p

Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB (UMich)
Ashbya (AGD) BOND GPMdb (Mass Spec.) YGAC Triples
Candida (CGD) BioPIXIE MIPS
Candida (CandidaDB) CYC2008 (complexes) Pfam domains
YGOB DIP PhosphoPep Database
YOGY
YeastRC Structure Prediction (Seattle)

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for Tkl1p ]

1) Sundstrom M, et al.  (1993) Yeast TKL1 gene encodes a transketolase that is required for efficient glycolysis and biosynthesis of aromatic amino acids. J Biol Chem 268(32):24346-52
2) Walfridsson M, et al.  (1995) Xylose-metabolizing Saccharomyces cerevisiae strains overexpressing the TKL1 and TAL1 genes encoding the pentose phosphate pathway enzymes transketolase and transaldolase. Appl Environ Microbiol 61(12):4184-90
3) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41