MRS2/YOR334W Protein Information Help

MRS2 BASIC PROTEIN INFORMATION

Standard Name Mrs2p 1
Systematic Name Yor334wp
ORF Classification Verified
Description Mitochondrial inner membrane Mg(2+) channel, required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns ( 2, 3 )
Name Description Mitochondrial RNA Splicing 4
Experimental Data
Molecules/cell 768 5
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 470
Molecular Weight (Da) 54,202
Isoelectric Point (pI) 10.18

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Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Mrs2p (InterPro)
Physical Interactions There are 3 total curated physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | PSI-BLAST | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
Secondary Structure Prediction GCG:PepPlot | GCG:PepStruct | GCG:Helical Wheel
External Sequence Databases EBI: Q01926 | UPI000012F58C
MIPS: YOR334W
NCBI: NP_014979.1 | 6324909
External Classifications TC: 1.A.35.5
Amino Acid Sequence (or in FASTA format)
 
       1  MNRRLLVRSI SCFQPLSRIT FGRPNTPFLR KYADTSTAAN TNSTILRKQL
      51  LSLKPISASD SLFISCTVFN SKGNIISMSE KFPKWSFLTE HSLFPRDLRK
     101  IDNSSIDIIP TIMCKPNCIV INLLHIKALI ERDKVYVFDT TNPSAAAKLS
     151  VLMYDLESKL SSTKNNSQFY EHRALESIFI NVMSALETDF KLHSQICIQI
     201  LNDLENEVNR LKLRHLLIKS KDLTLFYQKT LLIRDLLDEL LENDDDLANM
     251  YLTVKKSPKD NFSDLEMLIE TYYTQCDEYV QQSESLIQDI KSTEEIVNII
     301  LDANRNSLML LELKVTIYTL GFTVASVLPA FYGMNLKNFI EESEWGFTSV
     351  AVFSIVSALY ITKKNFNSLR SVTKMTMYPN SPANSSVYPK TSASIALTNK
     401  LKRRRKWWKS TKQRLGVLLY GSSYTNKANL SNNKINKGFS KVKKFNMEND
     451  IKNKQNRDMI WKWLIEDKKN *

EXTERNAL LINKS for Mrs2p

Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YGAC Triples
Ashbya (AGD) BOND GPMdb (Mass Spec.)
Candida (CGD) BioPIXIE MIPS
Candida (CandidaDB) CYC2008 (complexes) Pfam domains
YGOB DIP PhosphoPep Database
YOGY
TCDB

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for Mrs2p ]

1) Wiesenberger G, et al.  (1992) The nuclear gene MRS2 is essential for the excision of group II introns from yeast mitochondrial transcripts in vivo. J Biol Chem 267(10):6963-9
2) Gregan J, et al.  (2001) Mitochondrial Mg(2+) homeostasis is critical for group II intron splicing in vivo. Genes Dev 15(17):2229-37
3) Kolisek M, et al.  (2003) Mrs2p is an essential component of the major electrophoretic Mg2+ influx system in mitochondria. EMBO J 22(6):1235-44
4) Kreike J, et al.  (1986) Cloning of a nuclear gene MRS1 involved in the excision of a single group I intron (bI3) from the mitochondrial COB transcript in S. cerevisiae. Curr Genet 11(3):185-91
5) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41