FIS1/YIL065C Protein Information Help

FIS1 BASIC PROTEIN INFORMATION

Standard Name Fis1p
Systematic Name Yil065cp
Alias Mdv2p
ORF Classification Verified
Description Protein involved in mitochondrial membrane fission and peroxisome abundance; required for localization of Dnm1p and Mdv1p during mitochondrial division; mediates ethanol-induced apoptosis and ethanol-induced mitochondrial fragmentation ( 1, 2, 3 )
Name Description mitochondrial FISsion
Experimental Data
Molecules/cell 2410 4
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 155
Molecular Weight (Da) 17,733
Isoelectric Point (pI) 9.87

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Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Fis1p (InterPro)
Transmembrane Domains There are 1 total predicted transmembrane domains (TMHMM)
Physical Interactions There are 34 total curated physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | PSI-BLAST | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
Secondary Structure Prediction GCG:PepPlot | GCG:PepStruct | GCG:Helical Wheel
External Sequence Databases EBI: P40515 | UPI000013B3E1
MIPS: YIL065C
NCBI: NP_012199.1 | 6322124
Amino Acid Sequence (or in FASTA format)
 
       1  MTKVDFWPTL KDAYEPLYPQ QLEILRQQVV SEGGPTATIQ SRFNYAWGLI
      51  KSTDVNDERL GVKILTDIYK EAESRRRECL YYLTIGCYKL GEYSMAKRYV
     101  DTLFEHERNN KQVGALKSMV EDKIQKETLK GVVVAGGVLA GAVAVASFFL
     151  RNKRR*

EXTERNAL LINKS for Fis1p

Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YGAC Triples
Ashbya (AGD) BOND GPMdb (Mass Spec.)
Candida (CGD) BioPIXIE MIPS
Candida (CandidaDB) CYC2008 (complexes) Pfam domains
YGOB DIP PhosphoPep Database
YOGY

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for Fis1p ]

1) Mozdy AD, et al.  (2000) Dnm1p GTPase-mediated mitochondrial fission is a multi-step process requiring the novel integral membrane component Fis1p. J Cell Biol 151(2):367-80
2) Kuravi K, et al.  (2006) Dynamin-related proteins Vps1p and Dnm1p control peroxisome abundance in Saccharomyces cerevisiae. J Cell Sci 119(Pt 19):3994-4001
3) Kitagaki H, et al.  (2007) Ethanol-induced death in yeast exhibits features of apoptosis mediated by mitochondrial fission pathway. FEBS Lett 581(16):2935-42
4) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41