DAD3/YBR233W-A Protein Information 
| Standard Name | Dad3p 1 |
|---|---|
| Systematic Name | Ybr233w-ap |
| ORF Classification | Verified |
| Description | Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis (2, 3, 4, 5, 6) |
| Name Description | Duo1 And Dam1 interacting 1 |
| Experimental Data | |
|---|---|
| Molecules/cell | 468 7 |
| Click on image for expanded interactive view |
|---|
| Post-translational Modifications | PhosphoGRID | PhosphoPep Database |
|---|---|
| Domains/motifs | See the graphical view and list of proteins that share domains/motifs in common with Dad3p (InterPro) |
| Physical Interactions | There are 22 total physical interactions (BioGRID) |
| Homologs | PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer |
| External Sequence Databases |
EBI: UPI00001682C5 | P69850 MIPS: YBR233W-A NCBI: 21450619 | 67460131 | NP_631876.1 GenBank/EMBL/DDBJ: DAA07349.1 | Z36103 |
external links for Dad3p
| Homologs | Interaction Resources | Protein databases/Other | Localization Resources |
|---|---|---|---|
| BLASTP (NCBI) | BioGRID | SCOP Superfamily | YPL+ |
| Ashbya (AGD) | BOND | GPMdb (Mass Spec.) | YeastGFP |
| YGOB | BioPIXIE | MIPS | YeastRC Public Image Repository |
| YOGY | CYC2008 (complexes) | Pfam domains | |
| Complexome | |||
| GeneMANIA | |||
| YeastRC Mass Spec (Seattle) |
References cited on this page View Complete Literature Guide for Dad3p
| 1) | Cheeseman IM, et al. (2002) Phospho-regulation of kinetochore-microtubule attachments by the Aurora kinase Ipl1p. Cell 111(2):163-72 |
| 2) | Hofmann C, et al. (1998) Saccharomyces cerevisiae Duo1p and Dam1p, novel proteins involved in mitotic spindle function. J Cell Biol 143(4):1029-40 |
| 3) | Li Y, et al. (2002) The mitotic spindle is required for loading of the DASH complex onto the kinetochore. Genes Dev 16(2):183-97 |
| 4) | Miranda JJ, et al. (2005) The yeast DASH complex forms closed rings on microtubules. Nat Struct Mol Biol 12(2):138-43 |
| 5) | Westermann S, et al. (2005) Formation of a dynamic kinetochore- microtubule interface through assembly of the Dam1 ring complex. Mol Cell 17(2):277-90 |
| 6) | Westermann S, et al. (2006) The Dam1 kinetochore ring complex moves processively on depolymerizing microtubule ends. Nature 440(7083):565-9 |
| 7) | Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41 |
