KTI11/YBL071W-A Protein Information Help

Standard Name Kti11p 1, 2
Systematic Name Ybl071w-ap
Alias Dph3p 3
ORF Classification Verified
Description Zn-ribbon protein that co-purifies with Dph1 and Dph2; in a complex required for synthesis of diphthamide on translation factor eEF2 and with Elongator subunits Iki3p, Elp2p, and Elp3p; involved in modification of wobble nucleosides in tRNAs (2, 4, 5, 6, 7, 8)
Name Description Kluveromyces lactis Toxin Insensitive 9
Experimental Data
Molecules/cell 8400 10
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 82
Molecular Weight (Da) 9,356
Isoelectric Point (pI) 3.56

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Kti11p (InterPro)
Physical Interactions There are 36 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000015489E | Q3E840
NCBI: 21648335 | 62738697 | 84028910 | NP_660100.1 | NM_001184454.1
GenBank/EMBL/DDBJ: DAA07051.1 | Z35832
Amino Acid Sequence (or in FASTA format)
      51  SLMIDVVFDK EDLAEYYEEA GIHPPEPIAA AA*                  

external links for Kti11p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily LoQate
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Aspergillus (AspGD) CYC2008 (complexes) MIPS YeastGFP
Candida (CGD) Complexome Pfam domains YeastRC Public Image Repository
YGOB GeneMANIA YeastRC Structure Prediction (Seattle)

References cited on this page View Complete Literature Guide for Kti11p
1) Butler AR, et al.  (1994) Two Saccharomyces cerevisiae genes which control sensitivity to G1 arrest induced by Kluyveromyces lactis toxin. Mol Cell Biol 14(9):6306-16
2) Fichtner L and Schaffrath R  (2002) KTI11 and KTI13, Saccharomyces cerevisiae genes controlling sensitivity to G1 arrest induced by Kluyveromyces lactis zymocin. Mol Microbiol 44(3):865-75
3) Chen JY, et al.  (1985) Diphtheria toxin-resistant mutants of Saccharomyces cerevisiae. Mol Cell Biol 5(12):3357-60
4) Fichtner L, et al.  (2003) Elongator's toxin-target (TOT) function is nuclear localization sequence dependent and suppressed by post-translational modification. Mol Microbiol 49(5):1297-307
5) Liu S, et al.  (2004) Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2. Mol Cell Biol 24(21):9487-97
6) Huang B, et al.  (2005) An early step in wobble uridine tRNA modification requires the Elongator complex. RNA 11(4):424-36
7) Proudfoot M, et al.  (2008) Biochemical and structural characterization of a novel family of cystathionine beta-synthase domain proteins fused to a Zn ribbon-like domain. J Mol Biol 375(1):301-15
8) Bar C, et al.  (2008) A versatile partner of eukaryotic protein complexes that is involved in multiple biological processes: Kti11/Dph3. Mol Microbiol 69(5):1221-33
9) Butler AR, et al.  (1991) Intracellular expression of Kluyveromyces lactis toxin gamma subunit mimics treatment with exogenous toxin and distinguishes two classes of toxin-resistant mutant. Yeast 7(6):617-25
10) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41