MOS1/YCL057C-A Protein Information 
| Standard Name | Mos1p 1 |
|---|---|
| Systematic Name | Ycl057c-ap |
| Alias | Mio10p 2 , Mcs10p 3 |
| ORF Classification | Verified |
| Description | Mitochondrial protein essential for proper inner membrane organization; conserved component of the mitochondrial inner membrane organizing system (MICOS, MINOS, or MitOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture; ortholog of human MINOS1 (1, 2, 3, 4) |
| Name Description | Mitochondrial Organizing Structure 1 |
| Click on image for expanded interactive view |
|---|
| Post-translational Modifications | PhosphoGRID | PhosphoPep Database |
|---|---|
| Domains/motifs | See the graphical view and list of proteins that share domains/motifs in common with Mos1p (InterPro) |
| Transmembrane Domains | There are 1 total predicted transmembrane domains (TMHMM) |
| Physical Interactions | There are 66 total physical interactions (BioGRID) |
| Homologs | PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer |
| External Sequence Databases |
EBI: UPI000006B5EE | Q96VH5 MIPS: YCL057C-A NCBI: 10383755 | 14588901 | 51702129 | NP_065435.1 GenBank/EMBL/DDBJ: DAA07428.1 | X59720 |
external links for Mos1p
| Homologs | Interaction Resources | Protein databases/Other | Localization Resources |
|---|---|---|---|
| BLASTP (NCBI) | BioGRID | SCOP Superfamily | YPL+ |
| Ashbya (AGD) | BOND | GPMdb (Mass Spec.) | YeastGFP |
| Aspergillus (AspGD) | BioPIXIE | MIPS | |
| Candida (CGD) | CYC2008 (complexes) | Pfam domains | |
| Candida (CandidaDB) | Complexome | ||
| YGOB | GeneMANIA | ||
| YOGY |
References cited on this page View Complete Literature Guide for Mos1p
| 1) | Hoppins S, et al. (2011) A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria. J Cell Biol 195(2):323-40 |
| 2) | von der Malsburg K, et al. (2011) Dual role of mitofilin in mitochondrial membrane organization and protein biogenesis. Dev Cell 21(4):694-707 |
| 3) | Harner M, et al. (2011) The mitochondrial contact site complex, a determinant of mitochondrial architecture.LID - 10.1038/emboj.2011.379 [doi] EMBO J () |
| 4) | Alkhaja AK, et al. (2012) MINOS1 is a conserved component of mitofilin complexes and required for mitochondrial function and cristae organization. Mol Biol Cell 23(2):247-57 |
