HUG1/YML058W-A Protein Information 
| Standard Name | Hug1p 1 |
|---|---|
| Systematic Name | Yml058w-ap |
| ORF Classification | Verified |
| Description | Protein involved in the Mec1p-mediated checkpoint pathway; transcription is induced by DNA damage; protein abundance increases in response to DNA replication stress (1, 2) |
| Click on image for expanded interactive view |
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| Post-translational Modifications | PhosphoGRID | PhosphoPep Database |
|---|---|
| Domains/motifs | See the graphical view and list of proteins that share domains/motifs in common with Hug1p (InterPro) |
| Physical Interactions | There are 12 total physical interactions (BioGRID) |
| Homologs | PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer |
| External Sequence Databases |
EBI: UPI00001683BB | Q6Q5K6 MIPS: YML058W-A NCBI: 15530185 | 45269812 | 74611719 | NP_219498.1 GenBank/EMBL/DDBJ: DAA09839.1 | AY557960 | Z46729 |
external links for Hug1p
| Homologs | Interaction Resources | Protein databases/Other | Localization Resources |
|---|---|---|---|
| BLASTP (NCBI) | BioGRID | SCOP Superfamily | YPL+ |
| Ashbya (AGD) | BOND | GPMdb (Mass Spec.) | YeastGFP |
| YGOB | BioPIXIE | MIPS | YeastRC Public Image Repository |
| YOGY | CYC2008 (complexes) | Pfam domains | |
| Complexome | YeastRC Structure Prediction (Seattle) | ||
| GeneMANIA | |||
| YeastRC Two-Hybrid (Seattle) |
References cited on this page View Complete Literature Guide for Hug1p
| 1) | Basrai MA, et al. (1999) NORF5/HUG1 is a component of the MEC1-mediated checkpoint response to DNA damage and replication arrest in Saccharomyces cerevisiae. Mol Cell Biol 19(10):7041-9 |
| 2) | Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76 |
