HUG1/YML058W-A Protein Information Help

Standard Name Hug1p 1
Systematic Name Yml058w-ap
ORF Classification Verified
Description Protein involved in the Mec1p-mediated checkpoint pathway; transcription is induced by DNA damage; protein abundance increases in response to DNA replication stress (1, 2)
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 68
Molecular Weight (Da) 7,514
Isoelectric Point (pI) 8.42

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Hug1p (InterPro)
Physical Interactions There are 12 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI00001683BB | Q6Q5K6
NCBI: 15530185 | 45269812 | 74611719 | NP_219498.1 | NM_001184439.1
GenBank/EMBL/DDBJ: AAS56286.1 | DAA09839.1 | AY557960 | Z46729
Amino Acid Sequence (or in FASTA format)
      51  IAVERRGGLS DIGKNTSN*                                  

external links for Hug1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily LoQate
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
YGOB CYC2008 (complexes) MIPS YeastGFP
YOGY Complexome Pfam domains YeastRC Public Image Repository

GeneMANIA YeastRC Structure Prediction (Seattle)


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Hug1p
1) Basrai MA, et al.  (1999) NORF5/HUG1 is a component of the MEC1-mediated checkpoint response to DNA damage and replication arrest in Saccharomyces cerevisiae. Mol Cell Biol 19(10):7041-9
2) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76