ATP6/Q0085 Protein Information

Standard Name	Atp6p
Systematic Name	Q0085p
Alias	Oli2p , Oli4p , Pho1p
ORF Classification	Verified
Description	Mitochondrially encoded subunit a of the F0 sector of mitochondrial F1F0 ATP synthase; translation is specifically activated by Atp22p; ATP6 and ATP8 mRNAs are not translated in the absence of the F1 sector of ATPase (1, 2, 3)
Name Description	ATP synthase

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	259
Molecular Weight (Da)	29,099
Isoelectric Point (pI)	8.42

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Atp6p (InterPro)
Transmembrane Domains	There are 6 total predicted transmembrane domains (TMHMM)
Physical Interactions	There are 34 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000126351 \| P00854 MIPS: Q0085 NCBI: 13508 \| 13575 \| 21264385 \| 4160374 \| 6226527 \| 7537352 \| NP_009313.1 \| NM_001184360.1 GenBank/EMBL/DDBJ: AJ011856 \| J01464 \| V00683 \| X05056
External Classifications	EC: 3.6.3.14 [H(+)-transporting two-sector ATPase]

Amino Acid Sequence (or in FASTA format)
1 MFNLLNTYIT SPLDQFEIRT LFGLQSSFID LSCLNLTTFS LYTIIVLLVI 51 TSLYTLTNNN NKIIGSRWLI SQEAIYDTIM NMTKGQIGGK NWGLYFPMIF 101 TLFMFIFIAN LISMIPYSFA LSAHLVFIIS LSIVIWLGNT ILGLYKHGWV 151 FFSLFVPAGT PLPLVPLLVI IETLSYFARA ISLGLRLGSN ILAGHLLMVI 201 LAGLTFNFML INLFTLVFGF VPLAMILAIM MLEFAIGIIQ GYVWAILTAS 251 YLKDAVYLH*

Amino Acid Sequence (or in FASTA format)

       1  MFNLLNTYIT SPLDQFEIRT LFGLQSSFID LSCLNLTTFS LYTIIVLLVI
      51  TSLYTLTNNN NKIIGSRWLI SQEAIYDTIM NMTKGQIGGK NWGLYFPMIF
     101  TLFMFIFIAN LISMIPYSFA LSAHLVFIIS LSIVIWLGNT ILGLYKHGWV
     151  FFSLFVPAGT PLPLVPLLVI IETLSYFARA ISLGLRLGSN ILAGHLLMVI
     201  LAGLTFNFML INLFTLVFGF VPLAMILAIM MLEFAIGIIQ GYVWAILTAS
     251  YLKDAVYLH*

external links for Atp6p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS
Candida (CGD)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Atp6p

1)	John UP and Nagley P (1986) Amino acid substitutions in mitochondrial ATPase subunit 6 of Saccharomyces cerevisiae leading to oligomycin resistance. FEBS Lett 207(1):79-83
2)	Zeng X, et al. (2007) The Saccharomyces cerevisiae ATP22 gene codes for the mitochondrial ATPase subunit 6-specific translation factor. Genetics 175(1):55-63
3)	Rak M and Tzagoloff A (2009) F1-dependent translation of mitochondrially encoded Atp6p and Atp8p subunits of yeast ATP synthase. Proc Natl Acad Sci U S A 106(44):18509-14