AI3/Q0060 Protein Information

Standard Name	Ai3p
Systematic Name	Q0060p
ORF Classification	Verified
Description	Endonuclease I-SceIII, encoded by a mobile group I intron within the mitochondrial COX1 gene (1)
Gene Product	I-SceIII

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	415
Molecular Weight (Da)	47,917
Isoelectric Point (pI)	10.35

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Ai3p (InterPro)
Transmembrane Domains	There are 3 total predicted transmembrane domains (TMHMM)
Signal Peptide(s)	There are 1 total predicted predicted signal peptide(s) (SignalP)
Physical Interactions	There are 1 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI00001787BE \| P03877 MIPS: Q0060 NCBI: 1334436 \| 13527 \| 187608888 \| 4160369 \| 436897 \| 84028260 \| 85666122 \| NP_009308.2 GenBank/EMBL/DDBJ: AJ011856 \| U00801 \| V00694
External Classifications	EC: 3.1.-.- [Hydrolases acting on ester bonds ]

Amino Acid Sequence (or in FASTA format)
1 MVQRWLYSTN AKDIAVLYFM LAIFSGMAGT AMSLIIRLEL AAPGSQYLHG 51 NSQLFNVLVV GHAVLMIFFL VMPALIGGFG NQKRYESNNN NNQVMENKEY 101 NLKLNYDKLG PYLAGLIEGD GTITVQNSSS MKKSKYRPLI VVVFKLEDLE 151 LANYLCNLTK CGKVYKKINR NYVLWTIHDL KGVYTLLNII NGYMRTPKYE 201 AFVRGAEFMN NYINSTTITH NKLKNMDNIK IKPLDTSDIG SNAWLAGMTD 251 ADGNFSINLM NGKNRSSRAM PYYCLELRQN YQKNSNNNNI NFSYFYIMSA 301 IATYFNVNLY SRERNLNLLV STNNTYKTYY SYKVMVANTY KNIKVMEYFN 351 KYSLLSSKHL DFLDWSKLVI LINNEGQSMK TNGSWELGMN LRKDYNKTRT 401 TFTWSHLKNT YLENK*

Amino Acid Sequence (or in FASTA format)

       1  MVQRWLYSTN AKDIAVLYFM LAIFSGMAGT AMSLIIRLEL AAPGSQYLHG
      51  NSQLFNVLVV GHAVLMIFFL VMPALIGGFG NQKRYESNNN NNQVMENKEY
     101  NLKLNYDKLG PYLAGLIEGD GTITVQNSSS MKKSKYRPLI VVVFKLEDLE
     151  LANYLCNLTK CGKVYKKINR NYVLWTIHDL KGVYTLLNII NGYMRTPKYE
     201  AFVRGAEFMN NYINSTTITH NKLKNMDNIK IKPLDTSDIG SNAWLAGMTD
     251  ADGNFSINLM NGKNRSSRAM PYYCLELRQN YQKNSNNNNI NFSYFYIMSA
     301  IATYFNVNLY SRERNLNLLV STNNTYKTYY SYKVMVANTY KNIKVMEYFN
     351  KYSLLSSKHL DFLDWSKLVI LINNEGQSMK TNGSWELGMN LRKDYNKTRT
     401  TFTWSHLKNT YLENK*

external links for Ai3p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome
	GeneMANIA

References cited on this page View Complete Literature Guide for Ai3p

1)	Guo WW, et al. (1995) The mobile group I intron 3 alpha of the yeast mitochondrial COXI gene encodes a 35-kDa processed protein that is an endonuclease but not a maturase. J Biol Chem 270(26):15563-70