ARR1/YPR199C Protein Information

Standard Name	Arr1p
Systematic Name	Ypr199cp
Alias	Yap8p 1 , Acr1p 2
ORF Classification	Verified
Description	Transcriptional activator of the basic leucine zipper (bZIP) family, required for transcription of genes involved in resistance to arsenic compounds (2, 3, 4)
Name Description	ARsenicals Resistance

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	294
Molecular Weight (Da)	33,227
Isoelectric Point (pI)	8.05

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Arr1p (InterPro)
Physical Interactions	There are 46 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000012607A \| Q06596 MIPS: YPR199C NCBI: 2498101 \| 45270018 \| 6325457 \| 786310 \| NP_015525.1 GenBank/EMBL/DDBJ: DAA11613.1 \| AY558064 \| U25841

Amino Acid Sequence (or in FASTA format)
1 MAKPRGRKGG RKPSLTPPKN KRAAQLRASQ NAFRKRKLER LEELEKKEAQ 51 LTVTNDQIHI LKKENELLHF MLRSLLTERN MPSDERNISK ACCEEKPPTC 101 NTLDGSVVLS STYNSLEIQQ CYVFFKQLLS VCVGKNCTVP SPLNSFDRSF 151 YPIGCTNLSN DIPGYSFLND AMSEIHTFGD FNGELDSTFL EFSGTEIKEP 201 NNFITENTNA IETAAASMVI RQGFHPRQYY TVDAFGGDVL LSAMDIWSFM 251 KVHPKVNTFD LEILGTELKK SATCSNFDIL ISLKHFIKVF SSKL*

Amino Acid Sequence (or in FASTA format)

       1  MAKPRGRKGG RKPSLTPPKN KRAAQLRASQ NAFRKRKLER LEELEKKEAQ
      51  LTVTNDQIHI LKKENELLHF MLRSLLTERN MPSDERNISK ACCEEKPPTC
     101  NTLDGSVVLS STYNSLEIQQ CYVFFKQLLS VCVGKNCTVP SPLNSFDRSF
     151  YPIGCTNLSN DIPGYSFLND AMSEIHTFGD FNGELDSTFL EFSGTEIKEP
     201  NNFITENTNA IETAAASMVI RQGFHPRQYY TVDAFGGDVL LSAMDIWSFM
     251  KVHPKVNTFD LEILGTELKK SATCSNFDIL ISLKHFIKVF SSKL*

external links for Arr1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Arr1p

1)	Fernandes L, et al. (1997) Yap, a novel family of eight bZIP proteins in Saccharomyces cerevisiae with distinct biological functions. Mol Cell Biol 17(12):6982-93
2)	Bobrowicz P, et al. (1997) Isolation of three contiguous genes, ACR1, ACR2 and ACR3, involved in resistance to arsenic compounds in the yeast Saccharomyces cerevisiae. Yeast 13(9):819-28
3)	Bouganim N, et al. (2001) Yap1 overproduction restores arsenite resistance to the ABC transporter deficient mutant ycf1 by activating ACR3 expression. Biochem Cell Biol 79(4):441-8
4)	Bobrowicz P and Ulaszewski S (1998) Arsenical - induced transcriptional activation of the yeast Saccharomyces cerevisiae ACR2 and ACR3 genes requires the presence of the ACR1 gene product. Cell Mol Biol Lett 3:13-20