SGE1/YPR198W Protein Information

Standard Name	Sge1p
Systematic Name	Ypr198wp
Alias	Nor1p
ORF Classification	Verified
Description	Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations (1, 2, 3, 4)
Name Description	Suppression of Gal11 Expression 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	543
Molecular Weight (Da)	59,425
Isoelectric Point (pI)	8.05

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Sge1p (InterPro)
Transmembrane Domains	There are 14 total predicted transmembrane domains (TMHMM)
Signal Peptide(s)	There are 1 total predicted predicted signal peptide(s) (SignalP)
Physical Interactions	There are 25 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000135918 \| P33335 MIPS: YPR198W NCBI: 311155 \| 403576 \| 408092 \| 456361 \| 464760 \| 6325455 \| 786299 \| NP_015524.1 GenBank/EMBL/DDBJ: DAA11612.1 \| L11640 \| L24961 \| U02077 \| U25841 \| X77765
External Classifications	TC: 2.A.1.3 [The Drug:H+ Antiporter-2 (14 Spanner) (DHA2) Family]

Amino Acid Sequence (or in FASTA format)
1 MKSTLSLTLC VISLLLTLFL AALDIVIVVT LYDTIGIKFH DFGNIGWLVT 51 GYALSNAVFM LLWGRLAEIL GTKECLMISV IVFEIGSLIS ALSNSMATLI 101 SGRVVAGFGG SGIESLAFVV GTSIVRENHR GIMITALAIS YVIAEGVGPF 151 IGGAFNEHLS WRWCFYINLP IGAFAFIILA FCNTSGEPHQ KMWLPSKIKK 201 IMNYDYGELL KASFWKNTFE VLVFKLDMVG IILSSAGFTL LMLGLSFGGN 251 NFPWNSGIII CFFTVGPILL LLFCAYDFHF LSLSGLHYDN KRIKPLLTWN 301 IASNCGIFTS SITGFLSCFA YELQSAYLVQ LYQLVFKKKP TLASIHLWEL 351 SIPAMIATMA IAYLNSKYGI IKPAIVFGVL CGIVGSGLFT LINGELSQSI 401 GYSILPGIAF GSIFQATLLS SQVQITSDDP DFQNKFIEVT AFNSFAKSLG 451 FAFGGNMGAM IFTASLKNQM RSSQLNIPQF TSVETLLAYS TEHYDGPQSS 501 LSKFINTAIH DVFYCALGCY ALSFFFGIFT SSKKTTISAK KQQ*

Amino Acid Sequence (or in FASTA format)

       1  MKSTLSLTLC VISLLLTLFL AALDIVIVVT LYDTIGIKFH DFGNIGWLVT
      51  GYALSNAVFM LLWGRLAEIL GTKECLMISV IVFEIGSLIS ALSNSMATLI
     101  SGRVVAGFGG SGIESLAFVV GTSIVRENHR GIMITALAIS YVIAEGVGPF
     151  IGGAFNEHLS WRWCFYINLP IGAFAFIILA FCNTSGEPHQ KMWLPSKIKK
     201  IMNYDYGELL KASFWKNTFE VLVFKLDMVG IILSSAGFTL LMLGLSFGGN
     251  NFPWNSGIII CFFTVGPILL LLFCAYDFHF LSLSGLHYDN KRIKPLLTWN
     301  IASNCGIFTS SITGFLSCFA YELQSAYLVQ LYQLVFKKKP TLASIHLWEL
     351  SIPAMIATMA IAYLNSKYGI IKPAIVFGVL CGIVGSGLFT LINGELSQSI
     401  GYSILPGIAF GSIFQATLLS SQVQITSDDP DFQNKFIEVT AFNSFAKSLG
     451  FAFGGNMGAM IFTASLKNQM RSSQLNIPQF TSVETLLAYS TEHYDGPQSS
     501  LSKFINTAIH DVFYCALGCY ALSFFFGIFT SSKKTTISAK KQQ*

external links for Sge1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	TCDB
	DIP	YeastRC Structure Prediction (Seattle)
	GeneMANIA

References cited on this page View Complete Literature Guide for Sge1p

1)	Ehrenhofer-Murray AE, et al. (1994) The Saccharomyces cerevisiae SGE1 gene product: a novel drug-resistance protein within the major facilitator superfamily. Mol Gen Genet 244(3):287-94
2)	Ehrenhofer-Murray AE, et al. (1998) The Sge1 protein of Saccharomyces cerevisiae is a membrane-associated multidrug transporter. Yeast 14(1):49-65
3)	Jacquot C, et al. (1997) The Saccharomyces cerevisiae MFS superfamily SGE1 gene confers resistance to cationic dyes. Yeast 13(10):891-902
4)	Amakasu H, et al. (1993) Isolation and characterization of SGE1: a yeast gene that partially suppresses the gal11 mutation in multiple copies. Genetics 134(3):675-83