QCR2/YPR191W Protein Information

Standard Name	Qcr2p
Systematic Name	Ypr191wp
Alias	Cor2p , Ucr2p
ORF Classification	Verified
Description	Subunit 2 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; phosphorylated; transcription is regulated by Hap1p, Hap2p/Hap3p, and heme (1, 2, 3)
Name Description	ubiQuinol-cytochrome C oxidoReductase

Experimental Data
Molecules/cell	35700 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	368
Molecular Weight (Da)	40,478
Isoelectric Point (pI)	8.34

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Qcr2p (InterPro)
Physical Interactions	There are 55 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000137A4A \| P07257 MIPS: YPR191W NCBI: 136696 \| 14277713 \| 145579627 \| 188036281 \| 188036292 \| 188036304 \| 188036315 \| 20151119 \| 20151130 \| 24158772 \| 34811037 \| 3578 \| 45270026 \| 6325449 \| 786302 \| NP_015517.1 GenBank/EMBL/DDBJ: DAA11607.1 \| AY558068 \| U25841 \| X05120

Amino Acid Sequence (or in FASTA format)
1 MLSAARLQFA QGSVRRLTVS ARDAPTKIST LAVKVHGGSR YATKDGVAHL 51 LNRFNFQNTN TRSALKLVRE SELLGGTFKS TLDREYITLK ATFLKDDLPY 101 YVNALADVLY KTAFKPHELT ESVLPAARYD YAVAEQCPVK SAEDQLYAIT 151 FRKGLGNPLL YDGVERVSLQ DIKDFADKVY TKENLEVSGE NVVEADLKRF 201 VDESLLSTLP AGKSLVSKSE PKFFLGEENR VRFIGDSVAA IGIPVNKASL 251 AQYEVLANYL TSALSELSGL ISSAKLDKFT DGGLFTLFVR DQDSAVVSSN 301 IKKIVADLKK GKDLSPAINY TKLKNAVQNE SVSSPIELNF DAVKDFKLGK 351 FNYVAVGDVS NLPYLDEL*

Amino Acid Sequence (or in FASTA format)

       1  MLSAARLQFA QGSVRRLTVS ARDAPTKIST LAVKVHGGSR YATKDGVAHL
      51  LNRFNFQNTN TRSALKLVRE SELLGGTFKS TLDREYITLK ATFLKDDLPY
     101  YVNALADVLY KTAFKPHELT ESVLPAARYD YAVAEQCPVK SAEDQLYAIT
     151  FRKGLGNPLL YDGVERVSLQ DIKDFADKVY TKENLEVSGE NVVEADLKRF
     201  VDESLLSTLP AGKSLVSKSE PKFFLGEENR VRFIGDSVAA IGIPVNKASL
     251  AQYEVLANYL TSALSELSGL ISSAKLDKFT DGGLFTLFVR DQDSAVVSSN
     301  IKKIVADLKK GKDLSPAINY TKLKNAVQNE SVSSPIELNF DAVKDFKLGK
     351  FNYVAVGDVS NLPYLDEL*

external links for Qcr2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Candida (CGD)	BioPIXIE	MIPS	YeastGFP
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Qcr2p

1)	Dorsman JC and Grivell LA (1990) Expression of the gene encoding subunit II of yeast QH2: cytochrome c oxidoreductase is regulated by multiple factors. Curr Genet 17(6):459-64
2)	Oudshoorn P, et al. (1987) Subunit II of yeast QH2:cytochrome-c oxidoreductase. Nucleotide sequence of the gene and features of the protein. Eur J Biochem 163(1):97-103
3)	Reinders J, et al. (2007) Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase. Mol Cell Proteomics 6(11):1896-906
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41