HDA3/YPR179C Protein Information

Standard Name	Hda3p
Systematic Name	Ypr179cp
Alias	Plo1p
ORF Classification	Verified
Description	Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex that contains an Hda1p homodimer and an Hda2p-Hda3p heterodimer; required for the activity of the complex; has similarity to Hda2p (1, 2)
Name Description	Histone DeAcetylase 2

Experimental Data
Molecules/cell	1100 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	655
Molecular Weight (Da)	75,462
Isoelectric Point (pI)	6.3

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Hda3p (InterPro)
Physical Interactions	There are 24 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI00000531CF \| Q06623 MIPS: YPR179C NCBI: 256032681 \| 256032682 \| 256032683 \| 256032684 \| 256032685 \| 256032686 \| 6325437 \| 74676420 \| 786325 \| NP_015505.1 GenBank/EMBL/DDBJ: DAA11595.1 \| U25842

Amino Acid Sequence (or in FASTA format)
1 MDLLRILDTK PIPTIVDATT LGISGNTSGD YWLPTTMSLY QKELTDQIVS 51 LHYSDILRYF ETSHYKEDVI LESMKTMCLN GSLVATHPYL LIDHYMPKSL 101 ITRDVPAHLA ENSGKFSVLR DLINLVQEYE TETAIVCRPG RTMDLLEALL 151 LGNKVHIKRY DGHSIKSKQK ANDFSCTVHL FSSEGINFTK YPIKSKARFD 201 MLICLDTTVD TSQKDIQYLL QYKRERKGLE RYAPIVRLVA INSIDHCRLF 251 FGKKFDKNSR EYLENVTAAM VILRDRLGTL PPDLRPIYSQ KLHYLVEWLE 301 NPTVPWPLPD IYPLKQYTSM DVERSLLTEV HFKKSDDQLE DAFSNCSKKR 351 GRHGANKAAS STVAGIEDNI TPSFYSTKRL KNDYYTNPLK QDMTQLTGIT 401 TADNSSNVNY HLSSGIITHK LIQSMGEVYM DICVQKQELD DYSCLDDLQN 451 DHLKFFSNED EKIIKEYETV LRTNNENLNR SHELEVENNL KFSQIETLEK 501 DIETLKGSLM AQGETLSKLK DAFVKTDNVQ DEIEKEERVS VSRDTEKKYM 551 EQEIKRAVDA IRENEEETHK LNEKQNGLES ELKLKFEKSE ISTKELNEKI 601 GFLKKELKLE NDLNEELVGQ LSKTMDNLEN LTIPRVRTQN GNTKKKSRAK 651 KPGNV*

Amino Acid Sequence (or in FASTA format)

       1  MDLLRILDTK PIPTIVDATT LGISGNTSGD YWLPTTMSLY QKELTDQIVS
      51  LHYSDILRYF ETSHYKEDVI LESMKTMCLN GSLVATHPYL LIDHYMPKSL
     101  ITRDVPAHLA ENSGKFSVLR DLINLVQEYE TETAIVCRPG RTMDLLEALL
     151  LGNKVHIKRY DGHSIKSKQK ANDFSCTVHL FSSEGINFTK YPIKSKARFD
     201  MLICLDTTVD TSQKDIQYLL QYKRERKGLE RYAPIVRLVA INSIDHCRLF
     251  FGKKFDKNSR EYLENVTAAM VILRDRLGTL PPDLRPIYSQ KLHYLVEWLE
     301  NPTVPWPLPD IYPLKQYTSM DVERSLLTEV HFKKSDDQLE DAFSNCSKKR
     351  GRHGANKAAS STVAGIEDNI TPSFYSTKRL KNDYYTNPLK QDMTQLTGIT
     401  TADNSSNVNY HLSSGIITHK LIQSMGEVYM DICVQKQELD DYSCLDDLQN
     451  DHLKFFSNED EKIIKEYETV LRTNNENLNR SHELEVENNL KFSQIETLEK
     501  DIETLKGSLM AQGETLSKLK DAFVKTDNVQ DEIEKEERVS VSRDTEKKYM
     551  EQEIKRAVDA IRENEEETHK LNEKQNGLES ELKLKFEKSE ISTKELNEKI
     601  GFLKKELKLE NDLNEELVGQ LSKTMDNLEN LTIPRVRTQN GNTKKKSRAK
     651  KPGNV*

external links for Hda3p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Candida (CGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Hda3p

1)	Carmen AA, et al. (1996) HDA1 and HDA3 are components of a yeast histone deacetylase (HDA) complex. J Biol Chem 271(26):15837-44
2)	Wu J, et al. (2001) HDA2 and HDA3 are related proteins that interact with and are essential for the activity of the yeast histone deacetylase HDA1. Proc Natl Acad Sci U S A 98(8):4391-6
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41