PRP4/YPR178W Protein Information

Standard Name	Prp4p 1
Systematic Name	Ypr178wp
Alias	Rna4p
ORF Classification	Verified
Description	Splicing factor, component of the U4/U6-U5 snRNP complex (2)
Name Description	Pre-mRNA Processing 3

Experimental Data
Molecules/cell	1770 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	465
Molecular Weight (Da)	52,442
Isoelectric Point (pI)	5.33

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Prp4p (InterPro)
Physical Interactions	There are 130 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI00000530DA \| P20053 MIPS: YPR178W NCBI: 1017454 \| 130805 \| 172281 \| 6325435 \| 786318 \| NP_015504.1 \| NM_001184275.1 GenBank/EMBL/DDBJ: DAA11594.1 \| M26597 \| M28518 \| U25842

Amino Acid Sequence (or in FASTA format)
1 MSKYIALENL PVDLQHKGAT QNESTADILK QLPHERLQAV LEKIPEEDLE 51 VRRLLSILKK PEVVENEDVQ QRRIRLAEIL MVDEIDLENI NNMENINGEE 101 VDEEDDEDFF TPATSELIFA RRFLINYSLE RSRKRLQKEM ERHQKFNTRQ 151 ELLSRRTELQ RMANLELAGS QLVSTKPISA VSLSTDDMVV ATGSWAGDLQ 201 VLNSQTLQPL TQKLDSHVGK IGAIDWHPDS NNQMISCAED GLIKNFQYSN 251 EEGGLRLLGD LVGHERRISD VKYHPSGKFI GSASHDMTWR LWDASTHQEL 301 LLQEGHDKGV FSLSFQCDGS LVCSGGMDSL SMLWDIRSGS KVMTLAGHSK 351 PIYTVAWSPN GYQVATGGGD GIINVWDIRK RDEGQLNQIL AHRNIVTQVR 401 FSKEDGGKKL VSCGYDNLIN VYSSDTWLKM GSLAGHTDKI ISLDISNNSH 451 FLVSGGWDRS IKLWN*

Amino Acid Sequence (or in FASTA format)

       1  MSKYIALENL PVDLQHKGAT QNESTADILK QLPHERLQAV LEKIPEEDLE
      51  VRRLLSILKK PEVVENEDVQ QRRIRLAEIL MVDEIDLENI NNMENINGEE
     101  VDEEDDEDFF TPATSELIFA RRFLINYSLE RSRKRLQKEM ERHQKFNTRQ
     151  ELLSRRTELQ RMANLELAGS QLVSTKPISA VSLSTDDMVV ATGSWAGDLQ
     201  VLNSQTLQPL TQKLDSHVGK IGAIDWHPDS NNQMISCAED GLIKNFQYSN
     251  EEGGLRLLGD LVGHERRISD VKYHPSGKFI GSASHDMTWR LWDASTHQEL
     301  LLQEGHDKGV FSLSFQCDGS LVCSGGMDSL SMLWDIRSGS KVMTLAGHSK
     351  PIYTVAWSPN GYQVATGGGD GIINVWDIRK RDEGQLNQIL AHRNIVTQVR
     401  FSKEDGGKKL VSCGYDNLIN VYSSDTWLKM GSLAGHTDKI ISLDISNNSH
     451  FLVSGGWDRS IKLWN*

external links for Prp4p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Candida (CGD)	BioPIXIE	MIPS	YeastGFP
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Prp4p

1)	Petersen-Bjorn, S. and Friesen, J. (1989) Personal Communication, Mortimer Map Edition 10
2)	Stevens SW and Abelson J (1999) Purification of the yeast U4/U6.U5 small nuclear ribonucleoprotein particle and identification of its proteins. Proc Natl Acad Sci U S A 96(13):7226-31
3)	Vijayraghavan U, et al. (1989) Isolation and characterization of pre-mRNA splicing mutants of Saccharomyces cerevisiae. Genes Dev 3(8):1206-16
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41