BET2/YPR176C Protein Information

Standard Name	Bet2p 1
Systematic Name	Ypr176cp
ORF Classification	Verified
Description	Beta subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p (2, 3)
Name Description	Blocked Early in Transport 1

Experimental Data
Molecules/cell	1520 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	325
Molecular Weight (Da)	36,666
Isoelectric Point (pI)	4.89

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Bet2p (InterPro)
Physical Interactions	There are 16 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000012689E \| P20133 MIPS: YPR176C NCBI: 1352074 \| 45270024 \| 6325434 \| 786324 \| 808847 \| 808857 \| NP_015502.1 GenBank/EMBL/DDBJ: DAA11593.1 \| AY558067 \| M26597 \| M29585 \| U25842
External Classifications	EC: 2.5.1.60 [Protein geranylgeranyltransferase type II]

Amino Acid Sequence (or in FASTA format)
1 MSGSLTLLKE KHIRYIESLD TKKHNFEYWL TEHLRLNGIY WGLTALCVLD 51 SPETFVKEEV ISFVLSCWDD KYGAFAPFPR HDAHLLTTLS AVQILATYDA 101 LDVLGKDRKV RLISFIRGNQ LEDGSFQGDR FGEVDTRFVY TALSALSILG 151 ELTSEVVDPA VDFVLKCYNF DGGFGLCPNA ESHAAQAFTC LGALAIANKL 201 DMLSDDQLEE IGWWLCERQL PEGGLNGRPS KLPDVCYSWW VLSSLAIIGR 251 LDWINYEKLT EFILKCQDEK KGGISDRPEN EVDVFHTVFG VAGLSLMGYD 301 NLVPIDPIYC MPKSVTSKFK KYPYK*

Amino Acid Sequence (or in FASTA format)

       1  MSGSLTLLKE KHIRYIESLD TKKHNFEYWL TEHLRLNGIY WGLTALCVLD
      51  SPETFVKEEV ISFVLSCWDD KYGAFAPFPR HDAHLLTTLS AVQILATYDA
     101  LDVLGKDRKV RLISFIRGNQ LEDGSFQGDR FGEVDTRFVY TALSALSILG
     151  ELTSEVVDPA VDFVLKCYNF DGGFGLCPNA ESHAAQAFTC LGALAIANKL
     201  DMLSDDQLEE IGWWLCERQL PEGGLNGRPS KLPDVCYSWW VLSSLAIIGR
     251  LDWINYEKLT EFILKCQDEK KGGISDRPEN EVDVFHTVFG VAGLSLMGYD
     301  NLVPIDPIYC MPKSVTSKFK KYPYK*

external links for Bet2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Bet2p

1)	Newman AP and Ferro-Novick S (1987) Characterization of new mutants in the early part of the yeast secretory pathway isolated by a [3H]mannose suicide selection. J Cell Biol 105(4):1587-94
2)	Rossi G, et al. (1991) Dependence of Ypt1 and Sec4 membrane attachment on Bet2. Nature 351(6322):158-61
3)	Newman AP, et al. (1990) BET1, BOS1, and SEC22 are members of a group of interacting yeast genes required for transport from the endoplasmic reticulum to the Golgi complex. Mol Cell Biol 10(7):3405-14
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41