JIP5/YPR169W Protein Information

Standard Name	Jip5p 1
Systematic Name	Ypr169wp
ORF Classification	Verified
Description	Essential protein required for biogenesis of the large ribosomal subunit; interacts with proteins involved in RNA processing, ribosome biogenesis, ubiquitination and demethylation; similar to WDR55, a human WD repeat protein (2, 3, 4, 5, 6, 7, 8)
Name Description	Jumonji domain Interacting Protein 1

Experimental Data
Molecules/cell	7750 9

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	492
Molecular Weight (Da)	55,264
Isoelectric Point (pI)	4.89

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Jip5p (InterPro)
Physical Interactions	There are 20 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000065C6AA \| Q06214 MIPS: YPR169W NCBI: 189047099 \| 786294 \| 83578109 \| NP_015495.2 GenBank/EMBL/DDBJ: DAA11586.1 \| U25840

Amino Acid Sequence (or in FASTA format)
1 MAKSKKKTDV VDSTNLPILE LLSLKAPIFQ SLLHPELPII ITGFGTGHIV 51 CHRYDPAKLQ SHLDRRRRID TATTGKDAKK GVCPWIRLDI DLETGDLKFV 101 DIEEQQQQKQ TGKDEDLGVK TLWKTKRHKG SVRAMCFDSK GDNIFSVGSD 151 NVLKKANTMT GKVVKKVNLS SLFNSEEKKN DKFTKLCASQ THPFILIGDE 201 SGNIHVINSE NLALSNSIRS IHFGDSINDI FHFDKRSAYK FISLGQTTLA 251 YFDVRDKDAK PNVAGNEDGK ILISDDQEDE VLCGCFVDPE VADTLLCGMG 301 EGIVTVWKPN KNDLEDQMSR IKISKDESID CIVPTLQDDN CVWCGCSNGN 351 IYKVNAKLGK VVEIRNHSEL DEVSFVDLDF EYRVVSGGLE NIKIWELSSD 401 DVEENASVES DSDEPLSHSD EDLSDDTSSD DETTLVGLSK EELLDELDKD 451 LKEDHQEEKE SNSKSVKKRK IMKENNKKKD LYEHGIKKFD DL*

Amino Acid Sequence (or in FASTA format)

       1  MAKSKKKTDV VDSTNLPILE LLSLKAPIFQ SLLHPELPII ITGFGTGHIV
      51  CHRYDPAKLQ SHLDRRRRID TATTGKDAKK GVCPWIRLDI DLETGDLKFV
     101  DIEEQQQQKQ TGKDEDLGVK TLWKTKRHKG SVRAMCFDSK GDNIFSVGSD
     151  NVLKKANTMT GKVVKKVNLS SLFNSEEKKN DKFTKLCASQ THPFILIGDE
     201  SGNIHVINSE NLALSNSIRS IHFGDSINDI FHFDKRSAYK FISLGQTTLA
     251  YFDVRDKDAK PNVAGNEDGK ILISDDQEDE VLCGCFVDPE VADTLLCGMG
     301  EGIVTVWKPN KNDLEDQMSR IKISKDESID CIVPTLQDDN CVWCGCSNGN
     351  IYKVNAKLGK VVEIRNHSEL DEVSFVDLDF EYRVVSGGLE NIKIWELSSD
     401  DVEENASVES DSDEPLSHSD EDLSDDTSSD DETTLVGLSK EELLDELDKD
     451  LKEDHQEEKE SNSKSVKKRK IMKENNKKKD LYEHGIKKFD DL*

external links for Jip5p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
YGOB	CYC2008 (complexes)	Pfam domains
YOGY	Complexome
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Jip5p

1)	Tronnersjo S, et al. (2007) The jmjN and jmjC domains of the yeast zinc finger protein Gis1 interact with 19 proteins involved in transcription, sumoylation and DNA repair. Mol Genet Genomics 277(1):57-70
2)	Giaever G, et al. (2002) Functional profiling of the Saccharomyces cerevisiae genome. Nature 418(6896):387-91
3)	Hazbun TR, et al. (2003) Assigning function to yeast proteins by integration of technologies. Mol Cell 12(6):1353-65
4)	Graumann J, et al. (2004) Applicability of tandem affinity purification MudPIT to pathway proteomics in yeast. Mol Cell Proteomics 3(3):226-37
5)	Krogan NJ, et al. (2006) Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature 440(7084):637-43
6)	Perocchi F, et al. (2006) Assessing Systems Properties of Yeast Mitochondria through an Interaction Map of the Organelle. PLoS Genet 2(10):e170
7)	Oeffinger M, et al. (2007) Comprehensive analysis of diverse ribonucleoprotein complexes. Nat Methods 4(11):951-6
8)	Li Z, et al. (2009) Rational extension of the ribosome biogenesis pathway using network-guided genetics. PLoS Biol 7(10):e1000213
9)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41