MET16/YPR167C Protein Information

Standard Name	Met16p 1
Systematic Name	Ypr167cp
ORF Classification	Verified
Description	3'-phosphoadenylsulfate reductase, reduces 3'-phosphoadenylyl sulfate to adenosine-3',5'-bisphosphate and free sulfite using reduced thioredoxin as cosubstrate, involved in sulfate assimilation and methionine metabolism (2)
Name Description	METhionine requiring 1

Experimental Data
Molecules/cell	217 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	261
Molecular Weight (Da)	30,380
Isoelectric Point (pI)	5.83

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Met16p (InterPro)
Physical Interactions	There are 10 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000012F6C1 \| P18408 MIPS: YPR167C NCBI: 165760900 \| 165760901 \| 165760902 \| 165760903 \| 171936 \| 2507069 \| 51013923 \| 6325425 \| 786292 \| NP_015493.1 GenBank/EMBL/DDBJ: DAA11584.1 \| AY693236 \| J05591 \| U25840
External Classifications	EC: 1.8.4.8 [Phosphoadenylyl-sulfate reductase (thioredoxin)]

Amino Acid Sequence (or in FASTA format)
1 MKTYHLNNDI IVTQEQLDHW NEQLIKLETP QEIIAWSIVT FPHLFQTTAF 51 GLTGLVTIDM LSKLSEKYYM PELLFIDTLH HFPQTLTLKN EIEKKYYQPK 101 NQTIHVYKPD GCESEADFAS KYGDFLWEKD DDKYDYLAKV EPAHRAYKEL 151 HISAVFTGRR KSQGSARSQL SIIEIDELNG ILKINPLINW TFEQVKQYID 201 ANNVPYNELL DLGYRSIGDY HSTQPVKEGE DERAGRWKGK AKTECGIHEA 251 SRFAQFLKQD A*

Amino Acid Sequence (or in FASTA format)

       1  MKTYHLNNDI IVTQEQLDHW NEQLIKLETP QEIIAWSIVT FPHLFQTTAF
      51  GLTGLVTIDM LSKLSEKYYM PELLFIDTLH HFPQTLTLKN EIEKKYYQPK
     101  NQTIHVYKPD GCESEADFAS KYGDFLWEKD DDKYDYLAKV EPAHRAYKEL
     151  HISAVFTGRR KSQGSARSQL SIIEIDELNG ILKINPLINW TFEQVKQYID
     201  ANNVPYNELL DLGYRSIGDY HSTQPVKEGE DERAGRWKGK AKTECGIHEA
     251  SRFAQFLKQD A*

external links for Met16p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Met16p

1)	Masselot M and De Robichon-Szulmajster H (1975) Methionine biosynthesis in Saccharomyces cerevisiae. I. Genetical analysis of auxotrophic mutants. Mol Gen Genet 139(2):121-32
2)	Schwenn JD, et al. (1988) Yeast PAPS reductase: properties and requirements of the purified enzyme. Arch Microbiol 150(4):313-9
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41