URN1/YPR152C Protein Information

Standard Name	Urn1p 1, 2
Systematic Name	Ypr152cp
ORF Classification	Verified
Description	Putative protein of unknown function containing WW and FF domains; overexpression causes accumulation of cells in G1 phase (2, 3, 4)
Name Description	U2-U5-U6 snRNP, RES complex, and NTC interacting protein 1

Experimental Data
Molecules/cell	1310 5

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	465
Molecular Weight (Da)	54,138
Isoelectric Point (pI)	4.41

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Urn1p (InterPro)
Physical Interactions	There are 227 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000006B2C0 \| Q06525 MIPS: YPR152C NCBI: 1066497 \| 190613356 \| 51012931 \| 6325410 \| 74676412 \| NP_015478.1 GenBank/EMBL/DDBJ: DAA11564.1 \| AY692740 \| U40829

Amino Acid Sequence (or in FASTA format)
1 MRGEWQEFKT PAGKKYYYNK NTKQSRWEKP NLKKGSNLES NAKESQTERK 51 PTFSLELVNG WHLIIYNDGT KLYFNDDSKE FKNDISQEDD SRCRSLIESL 101 DKEKLVLLIG VARGYTMREE DIDKILESCN EEIHLFKRNQ DEVERKDEIS 151 EEAGDVKSPL QESHTGLVSG YGSSSGEEDE EEDEEEDEEN EEQIVNQDIS 201 IIDDLNRIDT DDIDERNIFF ELFDRYKLDK FSTWSLQSKK IENDPDFYKI 251 RDDTVRESLF EEWCGERSGN ATAEESDSED NSEDDSEVLE PTKYHYLAQI 301 VANAGTIAPD TIPQDIRKQQ KALYKAYKIK EYIPSKRDQD KFVSQLLFYY 351 KTFDLEQRKE IFCDCLRDHE RDFTGAVESL RQDKELIDRW QTLLKAPADS 401 SSIEDILLSI EHRCCVSPIV VTEPRYYVVG ILEKTVVWVR WLAAEVGPSS 451 RFTPVGAGNE PINPE*

Amino Acid Sequence (or in FASTA format)

       1  MRGEWQEFKT PAGKKYYYNK NTKQSRWEKP NLKKGSNLES NAKESQTERK
      51  PTFSLELVNG WHLIIYNDGT KLYFNDDSKE FKNDISQEDD SRCRSLIESL
     101  DKEKLVLLIG VARGYTMREE DIDKILESCN EEIHLFKRNQ DEVERKDEIS
     151  EEAGDVKSPL QESHTGLVSG YGSSSGEEDE EEDEEEDEEN EEQIVNQDIS
     201  IIDDLNRIDT DDIDERNIFF ELFDRYKLDK FSTWSLQSKK IENDPDFYKI
     251  RDDTVRESLF EEWCGERSGN ATAEESDSED NSEDDSEVLE PTKYHYLAQI
     301  VANAGTIAPD TIPQDIRKQQ KALYKAYKIK EYIPSKRDQD KFVSQLLFYY
     351  KTFDLEQRKE IFCDCLRDHE RDFTGAVESL RQDKELIDRW QTLLKAPADS
     401  SSIEDILLSI EHRCCVSPIV VTEPRYYVVG ILEKTVVWVR WLAAEVGPSS
     451  RFTPVGAGNE PINPE*

external links for Urn1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS	YeastRC Public Image Repository
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Urn1p

1)	Field DJ, et al. (2006) personal communication
2)	Bonet R, et al. (2008) Solution structure of the yeast URN1 splicing factor FF domain: Comparative analysis of charge distributions in FF domain structures-FFs and SURPs, two domains with a similar fold. Proteins 73(4):1001-1009
3)	Hesselberth JR, et al. (2006) Comparative analysis of Saccharomyces cerevisiae WW domains and their interacting proteins. Genome Biol 7(4):R30
4)	Niu W, et al. (2008) Mechanisms of Cell Cycle Control Revealed by a Systematic and Quantitative Overexpression Screen in S. cerevisiae. PLoS Genet 4(7):e1000120
5)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41