ISR1/YPR106W Protein Information

Standard Name	Isr1p
Systematic Name	Ypr106wp
ORF Classification	Verified
Description	Predicted protein kinase, overexpression causes sensitivity to staurosporine, which is a potent inhibitor of protein kinase C (1)
Name Description	Inhibition of Staurosporine Resistance

Experimental Data
Molecules/cell	521 2

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	443
Molecular Weight (Da)	49,735
Isoelectric Point (pI)	6.91

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Isr1p (InterPro)
Physical Interactions	There are 41 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000006C5C9 \| Q06098 MIPS: YPR106W NCBI: 6325363 \| 74676378 \| 914977 \| NP_015431.1 GenBank/EMBL/DDBJ: DAA11520.1 \| U32445
External Classifications	EC: 2.7.11.1 [Non-specific serine/threonine protein kinase]

Amino Acid Sequence (or in FASTA format)
1 MNSTPPTSPV TRVSDGSFPS ISNNSKGFAY RQPQKHKSNF AYSHLVSPVE 51 EPTAKFSEAF QTDYSSKAPV ATSEAHLKND LDVLFTTPRF YSPENLALMF 101 RLSNTVSSLE FLDEFLMGIL LAPEMDFLSN PSYSLPSNKL VGQGSYSYVY 151 PISSSASSRC NNDSGVVLKF AKSQHKSKVI LQEALTLAYL QYMSPSTNES 201 HIIPFYGLTY ITKSHFRRLR SNECVPGLIL PKCEMSLYHF NTAVSHKLSL 251 ITKRKIWWRL MKQMIDALKS LKTNGIIHGD IKTANILITE MHVLNGGHCK 301 DFDFYLADFT SAFHINQTPT DLNTTVEYCA PELIDSSSDH VPTFESDLYA 351 VGLCLLSFIS QHEPYNELQA LVSHGSSPGI GSSSIQQSQW LINALLKKDP 401 INLNMLRNDL FQDWKSELAL LSRILVDRLP LENLITILDS NYI*

Amino Acid Sequence (or in FASTA format)

       1  MNSTPPTSPV TRVSDGSFPS ISNNSKGFAY RQPQKHKSNF AYSHLVSPVE
      51  EPTAKFSEAF QTDYSSKAPV ATSEAHLKND LDVLFTTPRF YSPENLALMF
     101  RLSNTVSSLE FLDEFLMGIL LAPEMDFLSN PSYSLPSNKL VGQGSYSYVY
     151  PISSSASSRC NNDSGVVLKF AKSQHKSKVI LQEALTLAYL QYMSPSTNES
     201  HIIPFYGLTY ITKSHFRRLR SNECVPGLIL PKCEMSLYHF NTAVSHKLSL
     251  ITKRKIWWRL MKQMIDALKS LKTNGIIHGD IKTANILITE MHVLNGGHCK
     301  DFDFYLADFT SAFHINQTPT DLNTTVEYCA PELIDSSSDH VPTFESDLYA
     351  VGLCLLSFIS QHEPYNELQA LVSHGSSPGI GSSSIQQSQW LINALLKKDP
     401  INLNMLRNDL FQDWKSELAL LSRILVDRLP LENLITILDS NYI*

external links for Isr1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Isr1p

1)	Miyahara K, et al. (1998) Functional interaction of Isr1, a predicted protein kinase, with the Pkc1 pathway in Saccharomyces cerevisiae. Biosci Biotechnol Biochem 62(7):1376-80
2)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41