TEF1/YPR080W Protein Information Help

Standard Name Tef1p
Systematic Name Ypr080wp
ORF Classification Verified
Description Translational elongation factor EF-1 alpha; also encoded by TEF2; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus; TEF1 has a paralog, TEF2, that arose from the whole genome duplication (1, 2, 3) Also known as: EF-1 alpha
Name Description Translation Elongation Factor 1
Gene Product eEF1A 4
Experimental Data
Molecules/cell 377 5
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 458
Molecular Weight (Da) 50,032
Isoelectric Point (pI) 9.72

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Tef1p (InterPro)
Physical Interactions There are 144 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000053080 | P02994
MIPS: YPR080W
NCBI: 119161 | 12084705 | 1230686 | 14277980 | 14277982 | 171432 | 171434 | 171436 | 313261 | 32563240 | 32693291 | 32693293 | 32693295 | 32693297 | 3669 | 4607 | 476072 | 51013305 | 536396 | 6319594 | 6325337 | 9256877 | 99031870 | 99031872 | NP_009676.1 | NP_015405.1
GenBank/EMBL/DDBJ: DAA07236.1 | DAA11498.1 | AF402004 | AY130810 | AY130811 | AY130812 | AY130813 | AY692927 | M10992 | M15666 | M15667 | U51033 | X00779 | X01638 | X73532 | X78993 | Z35987
Amino Acid Sequence (or in FASTA format)
 
       1  MGKEKSHINV VVIGHVDSGK STTTGHLIYK CGGIDKRTIE KFEKEAAELG
      51  KGSFKYAWVL DKLKAERERG ITIDIALWKF ETPKYQVTVI DAPGHRDFIK
     101  NMITGTSQAD CAILIIAGGV GEFEAGISKD GQTREHALLA FTLGVRQLIV
     151  AVNKMDSVKW DESRFQEIVK ETSNFIKKVG YNPKTVPFVP ISGWNGDNMI
     201  EATTNAPWYK GWEKETKAGV VKGKTLLEAI DAIEQPSRPT DKPLRLPLQD
     251  VYKIGGIGTV PVGRVETGVI KPGMVVTFAP AGVTTEVKSV EMHHEQLEQG
     301  VPGDNVGFNV KNVSVKEIRR GNVCGDAKND PPKGCASFNA TVIVLNHPGQ
     351  ISAGYSPVLD CHTAHIACRF DELLEKNDRR SGKKLEDHPK FLKSGDAALV
     401  KFVPSKPMCV EAFSEYPPLG RFAVRDMRQT VAVGVIKSVD KTEKAAKVTK
     451  AAQKAAKK*

external links for Tef1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Aspergillus (AspGD) BioPIXIE MIPS YeastGFP
Candida (CGD) CYC2008 (complexes) Pfam domains YeastRC Public Image Repository
Candida (CGD) Complexome YeastRC Structure Prediction (Seattle)
Candida (CandidaDB) DIP

YGOB GeneMANIA

YOGY YeastRC Mass Spec (Seattle)

References cited on this page View Complete Literature Guide for Tef1p
1) Schirmaier F and Philippsen P  (1984) Identification of two genes coding for the translation elongation factor EF-1 alpha of S. cerevisiae. EMBO J 3(13):3311-5
2) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
3) Murthi A, et al.  (2010) Regulation of tRNA Bidirectional Nuclear-Cytoplasmic Trafficking in Saccharomyces cerevisiae. Mol Biol Cell 21(4):639-49
4) Carr-Schmid A, et al.  (1999) Mutations in a GTP-binding motif of eukaryotic elongation factor 1A reduce both translational fidelity and the requirement for nucleotide exchange. J Biol Chem 274(42):30297-302
5) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41