SPE3/YPR069C Protein Information

Standard Name	Spe3p
Systematic Name	Ypr069cp
ORF Classification	Verified
Description	Spermidine synthase, involved in biosynthesis of spermidine and also in biosynthesis of pantothenic acid; spermidine is required for growth of wild-type cells (1, 2)
Name Description	SPErmidine auxotroph 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	293
Molecular Weight (Da)	33,324
Isoelectric Point (pI)	5.33

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Spe3p (InterPro)
Physical Interactions	There are 15 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000052E6F \| Q12074 MIPS: YPR069C NCBI: 1230677 \| 1314137 \| 1326074 \| 2498945 \| 6325326 \| 805049 \| NP_015394.1 GenBank/EMBL/DDBJ: DAA11489.1 \| U27519 \| U51033 \| Z49219 \| Z71255
External Classifications	EC: 2.5.1.16 [Spermidine synthase]

Amino Acid Sequence (or in FASTA format)
1 MAQEITHPTI VDGWFREISD TMWPGQAMTL KVEKVLHHEK SKYQDVLIFK 51 STTYGNVLVL DNVIQATERD EFAYQEMIAH LALNSHPNPK KVLVIGGGDG 101 GVLREVVKHD SVEEAWLCDI DEAVIRLSKE YLPEMAASYS HPKVKTHIGD 151 GFQFLRDYQN TFDVIITDSS DPEGPAETLF QKEYFQLLNS ALTEKGVITT 201 QAESMWIHLP IIKDLKKACS EVFPVAEYSF VTIPTYPTGT IGFMVCSKDK 251 TCNVKKPLRE ISDEKEAELY RYYNKKIHEA SFVLPTWAAK ELN*

Amino Acid Sequence (or in FASTA format)

       1  MAQEITHPTI VDGWFREISD TMWPGQAMTL KVEKVLHHEK SKYQDVLIFK
      51  STTYGNVLVL DNVIQATERD EFAYQEMIAH LALNSHPNPK KVLVIGGGDG
     101  GVLREVVKHD SVEEAWLCDI DEAVIRLSKE YLPEMAASYS HPKVKTHIGD
     151  GFQFLRDYQN TFDVIITDSS DPEGPAETLF QKEYFQLLNS ALTEKGVITT
     201  QAESMWIHLP IIKDLKKACS EVFPVAEYSF VTIPTYPTGT IGFMVCSKDK
     251  TCNVKKPLRE ISDEKEAELY RYYNKKIHEA SFVLPTWAAK ELN*

external links for Spe3p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Spe3p

1)	Hamasaki-Katagiri N, et al. (1997) Spermidine biosynthesis in Saccharomyces cerevisae: polyamine requirement of a null mutant of the SPE3 gene (spermidine synthase). Gene 187(1):35-43
2)	White WH, et al. (2001) Saccharomyces cerevisiae is capable of de Novo pantothenic acid biosynthesis involving a novel pathway of beta-alanine production from spermine. J Biol Chem 276(14):10794-800
3)	Whitney PA and Morris DR (1978) Polyamine auxotrophs of Saccharomyces cerevisiae. J Bacteriol 134(1):214-20