TIF6/YPR016C Protein Information

Standard Name	Tif6p 1
Systematic Name	Ypr016cp
Alias	Cdc95p 2
ORF Classification	Verified
Description	Constituent of 66S pre-ribosomal particles, has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits (3)
Name Description	Translation Initiation Factor 1

Experimental Data
Molecules/cell	18600 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	245
Molecular Weight (Da)	26,457
Isoelectric Point (pI)	4.37

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Tif6p (InterPro)
Physical Interactions	There are 255 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000005310A \| Q12522 MIPS: YPR016C NCBI: 11513605 \| 1314090 \| 292659543 \| 3122261 \| 411024113 \| 51013283 \| 6325273 \| 887594 \| 939749 \| NP_015341.1 GenBank/EMBL/DDBJ: DAA11442.1 \| AY692916 \| U31900 \| Z49919 \| Z71255

Amino Acid Sequence (or in FASTA format)
1 MATRTQFENS NEIGVFSKLT NTYCLVAVGG SENFYSAFEA ELGDAIPIVH 51 TTIAGTRIIG RMTAGNRRGL LVPTQTTDQE LQHLRNSLPD SVKIQRVEER 101 LSALGNVICC NDYVALVHPD IDRETEELIS DVLGVEVFRQ TISGNILVGS 151 YCSLSNQGGL VHPQTSVQDQ EELSSLLQVP LVAGTVNRGS SVVGAGMVVN 201 DYLAVTGLDT TAPELSVIES IFRLQDAQPE SISGNLRDTL IETYS*

Amino Acid Sequence (or in FASTA format)

       1  MATRTQFENS NEIGVFSKLT NTYCLVAVGG SENFYSAFEA ELGDAIPIVH
      51  TTIAGTRIIG RMTAGNRRGL LVPTQTTDQE LQHLRNSLPD SVKIQRVEER
     101  LSALGNVICC NDYVALVHPD IDRETEELIS DVLGVEVFRQ TISGNILVGS
     151  YCSLSNQGGL VHPQTSVQDQ EELSSLLQVP LVAGTVNRGS SVVGAGMVVN
     201  DYLAVTGLDT TAPELSVIES IFRLQDAQPE SISGNLRDTL IETYS*

external links for Tif6p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Tif6p

1)	Si K and Maitra U (1999) The Saccharomyces cerevisiae homologue of mammalian translation initiation factor 6 does not function as a translation initiation factor. Mol Cell Biol 19(2):1416-26
2)	Wood LC, et al. (1999) Cloning of murine translation initiation factor 6 and functional analysis of the homologous sequence YPR016c in Saccharomyces cerevisiae. J Biol Chem 274(17):11653-9
3)	Horsey EW, et al. (2004) Role of the yeast Rrp1 protein in the dynamics of pre-ribosome maturation. RNA 10(5):813-27
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41