AIM45/YPR004C Protein Information

Standard Name	Aim45p 1
Systematic Name	Ypr004cp
ORF Classification	Verified
Description	Putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-alpha; interacts with frataxin, Yfh1p; null mutant displays elevated frequency of mitochondrial genome loss; may have a role in oxidative stress response (1, 2, 3, 4)
Name Description	Altered Inheritance rate of Mitochondria 1

Experimental Data
Molecules/cell	2950 5

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	344
Molecular Weight (Da)	36,802
Isoelectric Point (pI)	8.66

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Aim45p (InterPro)
Physical Interactions	There are 6 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000012A24B \| Q12480 MIPS: YPR004C NCBI: 1314079 \| 2833224 \| 51012721 \| 6325261 \| 763003 \| 939738 \| NP_015329.1 GenBank/EMBL/DDBJ: DAA11431.1 \| AY692635 \| U31900 \| Z48951 \| Z71255

Amino Acid Sequence (or in FASTA format)
1 MFKSLAAVLP RASKAKFLQK NYASTLAFIE SSKDGSVSRS SLSLLAAAQK 51 LSNPITAVIT GSKAEKTAEA LKSSYSCSNL EKLVIFEDSK LDTCLPEQLT 101 PLLVKLLKGG DYSHFVVSNS SVGKSVLPRV GALLDVQPVC EVTVIKDPKT 151 FIRPIYAGNI ISTIECQAEK KLLIIRASAF PPIAEGSMDS VTIEKRTDIP 201 PCDLNVTWVK TILTKSERPE LTSAQNVVTG GRALKDKETF EKLLSPLADV 251 LHAAIGATRA SVDNGLCDNS LQIGQTGKVV APNLYIAIGV SGAVQHLAGM 301 KDSKVIVAIN NDPDAPIFNV ADYGLQGDLY KIVPELTEKL GKYK*

Amino Acid Sequence (or in FASTA format)

       1  MFKSLAAVLP RASKAKFLQK NYASTLAFIE SSKDGSVSRS SLSLLAAAQK
      51  LSNPITAVIT GSKAEKTAEA LKSSYSCSNL EKLVIFEDSK LDTCLPEQLT
     101  PLLVKLLKGG DYSHFVVSNS SVGKSVLPRV GALLDVQPVC EVTVIKDPKT
     151  FIRPIYAGNI ISTIECQAEK KLLIIRASAF PPIAEGSMDS VTIEKRTDIP
     201  PCDLNVTWVK TILTKSERPE LTSAQNVVTG GRALKDKETF EKLLSPLADV
     251  LHAAIGATRA SVDNGLCDNS LQIGQTGKVV APNLYIAIGV SGAVQHLAGM
     301  KDSKVIVAIN NDPDAPIFNV ADYGLQGDLY KIVPELTEKL GKYK*

external links for Aim45p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Candida (CGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Aim45p

1)	Hess DC, et al. (2009) Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis. PLoS Genet 5(3):e1000407
2)	Grandier-Vazeille X, et al. (2001) Yeast mitochondrial dehydrogenases are associated in a supramolecular complex. Biochemistry 40(33):9758-69
3)	Gonzalez-Cabo P, et al. (2005) Frataxin interacts functionally with mitochondrial electron transport chain proteins. Hum Mol Genet 14(15):2091-8
4)	Lopes J, et al. (2010) The Saccharomyces cerevisiae Genes, AIM45, YGR207c/CIR1 and YOR356w/CIR2, Are Involved in Cellular Redox State Under Stress Conditions. Open Microbiol J 4():75-82
5)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41