MDL2/YPL270W Protein Information Help

Standard Name Mdl2p
Systematic Name Ypl270wp
ORF Classification Verified
Description Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, required for respiratory growth at high temperature; similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis (1, 2)
Name Description MultiDrug resistance-Like 1
Experimental Data
Molecules/cell 3390 3
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 773
Molecular Weight (Da) 85,136
Isoelectric Point (pI) 9.75

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Mdl2p (InterPro)
Transmembrane Domains There are 3 total predicted transmembrane domains (TMHMM)
Physical Interactions There are 5 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI00001D47AA | P33311
MIPS: YPL270W
NCBI: 1370557 | 311095 | 37362699 | 51013733 | 84028222 | NP_015053.2
GenBank/EMBL/DDBJ: DAA11166.1 | AY693141 | L16959 | Z73626
External Classifications TC: 3.A.1.212 [The Mitochondrial Peptide Exporter (MPE) Family]
Amino Acid Sequence (or in FASTA format)
 
       1  MLNGRLPLLR LGICRNMLSR PRLAKLPSIR FRSLVTPSSS QLIPLSRLCL
      51  RSPAVGKSLI LQSFRCNSSK TVPETSLPSA SPISKGSARS AHAKEQSKTD
     101  DYKDIIRLFM LAKRDWKLLL TAILLLTISC SIGMSIPKVI GIVLDTLKTS
     151  SGSDFFDLKI PIFSLPLYEF LSFFTVALLI GCAANFGRFI LLRILSERVV
     201  ARLRANVIKK TLHQDAEFFD NHKVGDLISR LGSDAYVVSR SMTQKVSDGV
     251  KALICGVVGV GMMCSLSPQL SILLLFFTPP VLFSASVFGK QIRNTSKDLQ
     301  EATGQLTRVA EEQLSGIKTV QSFVAEGNEL SRYNVAIRDI FQVGKTAAFT
     351  NAKFFTTTSL LGDLSFLTVL AYGSYLVLQS QLSIGDLTAF MLYTEYTGNA
     401  VFGLSTFYSE IMQGAGAASR LFELTDRKPS ISPTVGHKYK PDRGVIEFKD
     451  VSFSYPTRPS VQIFKNLNFK IAPGSSVCIV GPSGRGKSTI ALLLLRYYNP
     501  TTGTITIDNQ DISKLNCKSL RRHIGIVQQE PVLMSGTIRD NITYGLTYTP
     551  TKEEIRSVAK QCFCHNFITK FPNTYDTVIG PHGTLLSGGQ KQRIAIARAL
     601  IKKPTILILD EATSALDVES EGAINYTFGQ LMKSKSMTIV SIAHRLSTIR
     651  RSENVIVLGH DGSVVEMGKF KELYANPTSA LSQLLNEKAA PGPSDQQLQI
     701  EKVIEKEDLN ESKEHDDQKK DDNDDNDNNH DNDSNNQSPE TKDNNSDDIE
     751  KSVEHLLKDA AKEANPIKIT PQP*

external links for Mdl2p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Candida (CGD) BioPIXIE MIPS
Candida (CandidaDB) CYC2008 (complexes) Pfam domains
YGOB Complexome TCDB
YOGY DIP YeastRC Structure Prediction (Seattle)

GeneMANIA

References cited on this page View Complete Literature Guide for Mdl2p
1) Dean M, et al.  (1994) Mapping and sequencing of two yeast genes belonging to the ATP-binding cassette superfamily. Yeast 10(3):377-83
2) Young L, et al.  (2001) Role of the ABC transporter Mdl1 in peptide export from mitochondria. Science 291(5511):2135-8
3) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41