PLC1/YPL268W Protein Information Help

Standard Name Plc1p 1
Systematic Name Ypl268wp
ORF Classification Verified
Description Phospholipase C, hydrolyzes phosphatidylinositol 4,5-biphosphate (PIP2) to generate the signaling molecules inositol 1,4,5-triphosphate (IP3) and 1,2-diacylglycerol (DAG); involved in regulating many cellular processes (2, 3)
Name Description PhosphoLipase C 1
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 869
Molecular Weight (Da) 100,547
Isoelectric Point (pI) 9.84

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Plc1p (InterPro)
Physical Interactions There are 13 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000131BCD | P32383
MIPS: YPL268W
NCBI: 1370553 | 2326847 | 287612 | 295642 | 417490 | 6324987 | 7548846 | NP_015055.1
GenBank/EMBL/DDBJ: DAA11168.1 | D12738 | L13036 | S63468 | Z73623 | Z73624
External Classifications EC: 3.1.4.11 [Phosphoinositide phospholipase C]
Amino Acid Sequence (or in FASTA format)
 
       1  MTESAIDDQR FNLTKELQRH SCRDQGKITQ KDDALDFISY SSFQSSFNTD
      51  QKSANNGSTV RRSIRSIFRR AAELPRVHMG PLTYSHGINE LVNKKLRKDC
     101  DLSTLCRVLQ RGIRMIRMTR RRRKFYEFKL INNNGQIIWK DGSKYLELDS
     151  VKDIRIGDTA STYQEEVDPK RLRSDSKLWI AIIYKVSNKL KALHVVALNE
     201  LDFNTFLSCI CGLVKLRREL MESILLPDNS QFARIHWQIT VSEKEEDEKK
     251  DTLSFADVKK LCDKFHIYVS TGQLLEFFQL ADINHNGLLN YFEFEKFIKI
     301  LKNRKEVNMI WSKFTKPPHS HLSFENFFQF LITEQHEQVD RQTAWSYFIK
     351  YREPTQLTMG QDGFTKFLKE QPYLVEVKEE LYSKPLNHYF IASSHNTYLL
     401  GKQIAETPSV EGYIQVLQQG CRCVEIDIWD GENGPVVCHG FLTSAIPLKT
     451  VIRVIKKYAF ITSPYPLIIS LEINCNKDNQ KLASLIMREV LAEQLYFVGT
     501  RTDKLPSPRE LKHKILLKSK KTSEATRGLS VNEPFPSSFS SSYESANEQE
     551  LRMKDDSTNS SSATNSSSMQ RIKRIGLKKH ADIINDVSNI SGIHGIKFRN
     601  FSLPESKTIA HCFSLNERKV EYMIKDKHLK LSLDKHNRRY LMRVYPHVLR
     651  YKSSNFNPIP FWKAGVQMVA TNWQTNDIGQ QLNLAMFQIL DHQPDGSFKS
     701  GYVLKPKKLL PVVTKAKMIP LIYEHFENGS DPVTVKIRIL STQLLPRLND
     751  TSPSRNNTNS FVKVEFHTDD EPTMPISIDK GTRISATEAS TKSSQGNGFN
     801  PIWDAEVSIT LKDTDLTFIK FMVISEETQI ASVCLKLNYL RMGYRHIPLF
     851  NMEGEQYIFC TLFIHTQIL*

external links for Plc1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Candida (CGD) BioPIXIE MIPS
Candida (CandidaDB) CYC2008 (complexes) Pfam domains
YGOB Complexome YeastRC Structure Prediction (Seattle)
YOGY GeneMANIA

References cited on this page View Complete Literature Guide for Plc1p
1) Yoko-o T, et al.  (1993) The putative phosphoinositide-specific phospholipase C gene, PLC1, of the yeast Saccharomyces cerevisiae is important for cell growth. Proc Natl Acad Sci U S A 90(5):1804-8
2) Flick JS and Thorner J  (1998) An essential function of a phosphoinositide-specific phospholipase C is relieved by inhibition of a cyclin-dependent protein kinase in the yeast Saccharomyces cerevisiae. Genetics 148(1):33-47
3) Yoko-o T, et al.  (1995) Isolation and characterization of temperature-sensitive plc1 mutants of the yeast Saccharomyces cerevisiae. Mol Gen Genet 247(2):148-56