VIK1/YPL253C Protein Information

Standard Name	Vik1p
Systematic Name	Ypl253cp
ORF Classification	Verified
Description	Protein that forms a complex with Kar3p at the spindle pole body; possible regulator of Kar3p function in microtubule-mediated processes; required for sister chromatid cohesion; VIK1 has a paralog, CIK1, that arose from the whole genome duplication (1, 2, 3)
Name Description	Vegetative Interaction with Kar3p 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	647
Molecular Weight (Da)	75,729
Isoelectric Point (pI)	7.82

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Vik1p (InterPro)
Physical Interactions	There are 11 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000006C6C9 \| Q12045 MIPS: YPL253C NCBI: 1061236 \| 1370520 \| 145579923 \| 2326844 \| 392935686 \| 6325002 \| 74583794 \| NP_015070.1 GenBank/EMBL/DDBJ: DAA11184.1 \| Z67751 \| Z73608 \| Z73609

Amino Acid Sequence (or in FASTA format)
1 MASQQNKHAF LSKNRIFHNP DNVSSSKSRN LMDITNTTNT MNGSRPSSMK 51 SSLALPPVKD SFPSVSRSAS LNINMSKIKD LKDRQDKIRF QRHTLRTQLI 101 ECEREIKTIK FRDLNKSRFE LYKKKSKQAK YLKQVRDLTQ NLNSKDGERA 151 DLIKKNKSAL ATLQAELDQN LILKRQESQE LYNNKLIFWE NELQIMENVE 201 PDHEITEEIS QLKKTLQELN INWANLQKQN LERQVNHESQ LRKDFIAFKE 251 AKLKSMENLT NKHRELLDQI ATLQSESEKL HKEIMDIDRQ AEYSEQNISE 301 INENIKQLEL ANNPLISKSL QNSQDLEHLQ NQMENLKEMA SKQEKFYNDT 351 YNTVEKELLR SRRLENSIIE QKGTMRCYAY VMEQNLPENL LFDYENGVIT 401 QGLSEHVYKF NRVIPHLKVS EDKFFTQEYS VYHDMCLNQK KNFNLISLST 451 TPHGSLRESL IKFLAEKDTI YQKQYVITLQ FVFLSDDEFS QDMLLDYSHN 501 DKDSIKLKFE KHSISLDSKL VIIENGLEDL PLNFSCDEHP NLPHSGMGII 551 KVQFFPRDSK SDGNNDPVPV DFYFIELNNL KSIEQFDKSI FKKESCETPI 601 ALVLKKLISD TKSFFLLNLN DSKNVNKLLT ISEEVQTQLC KRKKKLT*

Amino Acid Sequence (or in FASTA format)

       1  MASQQNKHAF LSKNRIFHNP DNVSSSKSRN LMDITNTTNT MNGSRPSSMK
      51  SSLALPPVKD SFPSVSRSAS LNINMSKIKD LKDRQDKIRF QRHTLRTQLI
     101  ECEREIKTIK FRDLNKSRFE LYKKKSKQAK YLKQVRDLTQ NLNSKDGERA
     151  DLIKKNKSAL ATLQAELDQN LILKRQESQE LYNNKLIFWE NELQIMENVE
     201  PDHEITEEIS QLKKTLQELN INWANLQKQN LERQVNHESQ LRKDFIAFKE
     251  AKLKSMENLT NKHRELLDQI ATLQSESEKL HKEIMDIDRQ AEYSEQNISE
     301  INENIKQLEL ANNPLISKSL QNSQDLEHLQ NQMENLKEMA SKQEKFYNDT
     351  YNTVEKELLR SRRLENSIIE QKGTMRCYAY VMEQNLPENL LFDYENGVIT
     401  QGLSEHVYKF NRVIPHLKVS EDKFFTQEYS VYHDMCLNQK KNFNLISLST
     451  TPHGSLRESL IKFLAEKDTI YQKQYVITLQ FVFLSDDEFS QDMLLDYSHN
     501  DKDSIKLKFE KHSISLDSKL VIIENGLEDL PLNFSCDEHP NLPHSGMGII
     551  KVQFFPRDSK SDGNNDPVPV DFYFIELNNL KSIEQFDKSI FKKESCETPI
     601  ALVLKKLISD TKSFFLLNLN DSKNVNKLLT ISEEVQTQLC KRKKKLT*

external links for Vik1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS	YeastRC Public Image Repository
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Vik1p

1)	Manning BD, et al. (1999) Differential regulation of the Kar3p kinesin-related protein by two associated proteins, Cik1p and Vik1p. J Cell Biol 144(6):1219-33
2)	Mayer ML, et al. (2004) Identification of protein complexes required for efficient sister chromatid cohesion. Mol Biol Cell 15(4):1736-45
3)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61