VIK1/YPL253C Protein Information Help

Standard Name Vik1p 1
Systematic Name Ypl253cp
ORF Classification Verified
Description Protein that forms a kinesin-14 heterodimeric motor with Kar3p; localizes Kar3p at mitotic spindle poles; has a structure similar to a kinesin motor domain but lacks an ATP-binding site and is catalytically inactive; binds microtubules; required for sister chromatid cohesion; VIK1 has a paralog, CIK1, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description Vegetative Interaction with Kar3p 1
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 647
Molecular Weight (Da) 75,729
Isoelectric Point (pI) 7.82

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Vik1p (InterPro)
Physical Interactions There are 12 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000006C6C9 | Q12045
MIPS: YPL253C
NCBI: 1061236 | 1370520 | 145579923 | 2326844 | 392935686 | 6325002 | 74583794 | NP_015070.1 | NM_001184067.1
GenBank/EMBL/DDBJ: CAA91591.1 | CAA97977.1 | CAA97978.1 | DAA11184.1 | Z67751 | Z73608 | Z73609
Amino Acid Sequence (or in FASTA format)
       1  MASQQNKHAF LSKNRIFHNP DNVSSSKSRN LMDITNTTNT MNGSRPSSMK
      51  SSLALPPVKD SFPSVSRSAS LNINMSKIKD LKDRQDKIRF QRHTLRTQLI
     101  ECEREIKTIK FRDLNKSRFE LYKKKSKQAK YLKQVRDLTQ NLNSKDGERA
     151  DLIKKNKSAL ATLQAELDQN LILKRQESQE LYNNKLIFWE NELQIMENVE
     201  PDHEITEEIS QLKKTLQELN INWANLQKQN LERQVNHESQ LRKDFIAFKE
     251  AKLKSMENLT NKHRELLDQI ATLQSESEKL HKEIMDIDRQ AEYSEQNISE
     301  INENIKQLEL ANNPLISKSL QNSQDLEHLQ NQMENLKEMA SKQEKFYNDT
     351  YNTVEKELLR SRRLENSIIE QKGTMRCYAY VMEQNLPENL LFDYENGVIT
     401  QGLSEHVYKF NRVIPHLKVS EDKFFTQEYS VYHDMCLNQK KNFNLISLST
     451  TPHGSLRESL IKFLAEKDTI YQKQYVITLQ FVFLSDDEFS QDMLLDYSHN
     501  DKDSIKLKFE KHSISLDSKL VIIENGLEDL PLNFSCDEHP NLPHSGMGII
     551  KVQFFPRDSK SDGNNDPVPV DFYFIELNNL KSIEQFDKSI FKKESCETPI
     601  ALVLKKLISD TKSFFLLNLN DSKNVNKLLT ISEEVQTQLC KRKKKLT*  

external links for Vik1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily LoQate
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
YGOB CYC2008 (complexes) MIPS YeastGFP
YOGY Complexome Pfam domains YeastRC Public Image Repository

DIP YeastRC Structure Prediction (Seattle)

GeneMANIA


IMP


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Vik1p
1) Manning BD, et al.  (1999) Differential regulation of the Kar3p kinesin-related protein by two associated proteins, Cik1p and Vik1p. J Cell Biol 144(6):1219-33
2) Mayer ML, et al.  (2004) Identification of protein complexes required for efficient sister chromatid cohesion. Mol Biol Cell 15(4):1736-45
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4) Allingham JS, et al.  (2007) Vik1 modulates microtubule-Kar3 interactions through a motor domain that lacks an active site. Cell 128(6):1161-72