GAL4/YPL248C Protein Information

Standard Name	Gal4p 1, 2
Systematic Name	Ypl248cp
Alias	Gal81p 3
ORF Classification	Verified
Description	DNA-binding transcription factor required for the activation of the GAL genes in response to galactose; repressed by Gal80p and activated by Gal3p (4)
Name Description	GALactose metabolism

Experimental Data
Molecules/cell	166 5

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	881
Molecular Weight (Da)	99,402
Isoelectric Point (pI)	7.14

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Gal4p (InterPro)
Physical Interactions	There are 157 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000000980 \| P04386 MIPS: YPL248C NCBI: 1061241 \| 1169823 \| 1370511 \| 157830113 \| 157878123 \| 157878124 \| 169404711 \| 169404712 \| 171558 \| 193506717 \| 193506718 \| 349868 \| 349869 \| 6325008 \| NP_015076.1 GenBank/EMBL/DDBJ: DAA11189.1 \| K01486 \| Z67751 \| Z73604

Amino Acid Sequence (or in FASTA format)
1 MKLLSSIEQA CDICRLKKLK CSKEKPKCAK CLKNNWECRY SPKTKRSPLT 51 RAHLTEVESR LERLEQLFLL IFPREDLDMI LKMDSLQDIK ALLTGLFVQD 101 NVNKDAVTDR LASVETDMPL TLRQHRISAT SSSEESSNKG QRQLTVSIDS 151 AAHHDNSTIP LDFMPRDALH GFDWSEEDDM SDGLPFLKTD PNNNGFFGDG 201 SLLCILRSIG FKPENYTNSN VNRLPTMITD RYTLASRSTT SRLLQSYLNN 251 FHPYCPIVHS PTLMMLYNNQ IEIASKDQWQ ILFNCILAIG AWCIEGESTD 301 IDVFYYQNAK SHLTSKVFES GSIILVTALH LLSRYTQWRQ KTNTSYNFHS 351 FSIRMAISLG LNRDLPSSFS DSSILEQRRR IWWSVYSWEI QLSLLYGRSI 401 QLSQNTISFP SSVDDVQRTT TGPTIYHGII ETARLLQVFT KIYELDKTVT 451 AEKSPICAKK CLMICNEIEE VSRQAPKFLQ MDISTTALTN LLKEHPWLSF 501 TRFELKWKQL SLIIYVLRDF FTNFTQKKSQ LEQDQNDHQS YEVKRCSIML 551 SDAAQRTVMS VSSYMDNHNV TPYFAWNCSY YLFNAVLVPI KTLLSNSKSN 601 AENNETAQLL QQINTVLMLL KKLATFKIQT CEKYIQVLEE VCAPFLLSQC 651 AIPLPHISYN NSNGSAIKNI VGSATIAQYP TLPEENVNNI SVKYVSPGSV 701 GPSPVPLKSG ASFSDLVKLL SNRPPSRNSP VTIPRSTPSH RSVTPFLGQQ 751 QQLQSLVPLT PSALFGGANF NQSGNIADSS LSFTFTNSSN GPNLITTQTN 801 SQALSQPIAS SNVHDNFMNN EITASKIDDG NNSKPLSPGW TDQTAYNAFG 851 ITTGMFNTTT MDDVYNYLFD DEDTPPNPKK E*

Amino Acid Sequence (or in FASTA format)

       1  MKLLSSIEQA CDICRLKKLK CSKEKPKCAK CLKNNWECRY SPKTKRSPLT
      51  RAHLTEVESR LERLEQLFLL IFPREDLDMI LKMDSLQDIK ALLTGLFVQD
     101  NVNKDAVTDR LASVETDMPL TLRQHRISAT SSSEESSNKG QRQLTVSIDS
     151  AAHHDNSTIP LDFMPRDALH GFDWSEEDDM SDGLPFLKTD PNNNGFFGDG
     201  SLLCILRSIG FKPENYTNSN VNRLPTMITD RYTLASRSTT SRLLQSYLNN
     251  FHPYCPIVHS PTLMMLYNNQ IEIASKDQWQ ILFNCILAIG AWCIEGESTD
     301  IDVFYYQNAK SHLTSKVFES GSIILVTALH LLSRYTQWRQ KTNTSYNFHS
     351  FSIRMAISLG LNRDLPSSFS DSSILEQRRR IWWSVYSWEI QLSLLYGRSI
     401  QLSQNTISFP SSVDDVQRTT TGPTIYHGII ETARLLQVFT KIYELDKTVT
     451  AEKSPICAKK CLMICNEIEE VSRQAPKFLQ MDISTTALTN LLKEHPWLSF
     501  TRFELKWKQL SLIIYVLRDF FTNFTQKKSQ LEQDQNDHQS YEVKRCSIML
     551  SDAAQRTVMS VSSYMDNHNV TPYFAWNCSY YLFNAVLVPI KTLLSNSKSN
     601  AENNETAQLL QQINTVLMLL KKLATFKIQT CEKYIQVLEE VCAPFLLSQC
     651  AIPLPHISYN NSNGSAIKNI VGSATIAQYP TLPEENVNNI SVKYVSPGSV
     701  GPSPVPLKSG ASFSDLVKLL SNRPPSRNSP VTIPRSTPSH RSVTPFLGQQ
     751  QQLQSLVPLT PSALFGGANF NQSGNIADSS LSFTFTNSSN GPNLITTQTN
     801  SQALSQPIAS SNVHDNFMNN EITASKIDDG NNSKPLSPGW TDQTAYNAFG
     851  ITTGMFNTTT MDDVYNYLFD DEDTPPNPKK E*

external links for Gal4p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS
YGOB	CYC2008 (complexes)	Pfam domains
YOGY	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Gal4p

1)	Haber, J. (1985) Personal Communication, Mortimer Map Edition 9
2)	Link, A. and Olson, M. (1989) Personal Communication, Mortimer Map Edition 10
3)	Hopper JE and Rowe LB (1978) Molecular expression and regulation of the galactose pathway genes in Saccharomyces cerevisiae. Distinct messenger RNAs specified by the Gali and Gal7 genes in the Gal7-Gal10-Gal1 cluster. J Biol Chem 253(20):7566-9
4)	Bhat PJ and Murthy TV (2001) Transcriptional control of the GAL/MEL regulon of yeast Saccharomyces cerevisiae: mechanism of galactose-mediated signal transduction. Mol Microbiol 40(5):1059-66
5)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41