IQG1/YPL242C Protein Information

Standard Name	Iqg1p
Systematic Name	Ypl242cp
Alias	Cyk1p
ORF Classification	Verified
Description	Essential protein required for determination of budding pattern; promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family; relocalizes from bud neck to cytoplasm upon DNA replication stress (1, 2, 3)
Name Description	IQGAP-related protein 2

Experimental Data
Molecules/cell	279 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	1,495
Molecular Weight (Da)	172,829
Isoelectric Point (pI)	9.61

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Iqg1p (InterPro)
Physical Interactions	There are 30 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000006B3DF \| Q12280 MIPS: YPL242C NCBI: 1061248 \| 1370499 \| 2425084 \| 55976295 \| 6325014 \| NP_015082.1 GenBank/EMBL/DDBJ: DAA11195.1 \| AF019644 \| Z67751 \| Z73598

Amino Acid Sequence (or in FASTA format)
1 MTAYSGSPSK PGNNNSYLNR YVENLGTNVT PPLRPQSSSK INSSLNIASP 51 SHLKTKTSAS NSSATILSKK VESSVSKLKP SLPNKLVGKY TVDLSNYSKI 101 ELRYYEFLCR VSEVKIWIEA VIEEALPSEI ELCVGDSLRN GVFLAKLTQR 151 INPDLTTVIF PAGDKLQFKH TQNINAFFGL VEHVGVPDSF RFELQDLYNK 201 KNIPQVFETL HILISMINKK WPGKTPALTN VSGQISFTKE EIAACKKAWP 251 RIRDFKSLGT NINTAPASPE EPKEKRSGLI KDFNKFERPN IPVEEILITP 301 RKNITDANCS DFSNTPSPYN EAPKMSNLDV VVEKRKFTPI EPSLLGPTPS 351 LEYSPIKNKS LSYYSPTISK YLTYDTEFYT RRSRAREEDL NYYQTFKYSP 401 SHYSPMRRER MTEEQFLEKV VQLQNICRGV NTRFNLYIQK RLLNLFEQDI 451 LRFQACLRGN KFRVLSSMYL PIRRAKIDVP HVEAIQSRIK GSRIRYKYDK 501 LKFTLSRFSC TVELLQAYCR SKLLKTTVNT KLNDIEISHY PLTKLQSYMR 551 ASYVRKKVMS LNTKLNDERE SIMKFSAIIR GNVVRCSEDA ILSAVHDVHK 601 ENISKLQSLI RGIFTRSCLA SIIYSLGKEN CNIIQLSACI RGNAVRHKVQ 651 SLFAPENNLS ETVHDLQGLV RGILVRYTLD LVDDIVEYNN LALFQAFSRG 701 ALVRESLDQK SSFYKRNVRS VIMIQSWIRK SLQRSAYLEL LDCPNPSLWA 751 VKKFVHLLNG TATIEEVQNQ LESCQASLDS ENMKKERLLK SIRQQLNING 801 VLDKFGLLKD KDHELGISDS TIPKSKYQKY EKLFYMLQVD PSYWKLLYLK 851 EPEFVAKNVY MTFGTVNQRM NDRERSYFTR FVCEMLQNAI NEAPSIESFL 901 DNRSQFWQTI LQDFLRRESP EFFSIIVPVL DYLSDPVVDF ESDPYKIYQE 951 IHGFSSPQHC SPVDDASTKN KFIDNLRCLW HAIEMVAEIY TRKVHTIPVE 1001 IRYLCTKIFC YAADKNIEEI DSLRAISSIL VNVFVSEYLV NREYYGYKDS 1051 NVQKNNQKID ILMKSLATVF EIKNFDGFLD PLNQYANEIK PHIKDVLYNV 1101 LVDPEYEQEG DRLIYLDMVS PSPKLELLTE KVLEISGKFE EYLNEFPEAD 1151 ILHDILEKNL DNSSFPRSGR VTLELDASAY RFLVSDDKMR KIYDQVKRAF 1201 VYMMQIEDVD TNLYDLSIST ILPQDEPNFA NFLEQNPKIR DDPMIQKLKP 1251 LKYFTLKNVT LKKIHELEST GTFCSSDNKL QNFLNDIANT IKNPNYAIDY 1301 VTQEIYITKE TLTKISEMNH SLDIELSRLK KHVDHTIKDF QKAKDFSPVH 1351 KSKFGNFKNA VKKVQGRERS ELQGMKFKWN TKQLYERGVL KTIRGEKLAE 1401 LTVKVFGSSG PKFPDIIFKI STSDGSRFGI QMIDKRKGPD KRYSDDVDSF 1451 SFKDLIKTQV EPKIETWKLF HSNVVVNNSQ LLHLIVSFFY KRNAL*

Amino Acid Sequence (or in FASTA format)

       1  MTAYSGSPSK PGNNNSYLNR YVENLGTNVT PPLRPQSSSK INSSLNIASP
      51  SHLKTKTSAS NSSATILSKK VESSVSKLKP SLPNKLVGKY TVDLSNYSKI
     101  ELRYYEFLCR VSEVKIWIEA VIEEALPSEI ELCVGDSLRN GVFLAKLTQR
     151  INPDLTTVIF PAGDKLQFKH TQNINAFFGL VEHVGVPDSF RFELQDLYNK
     201  KNIPQVFETL HILISMINKK WPGKTPALTN VSGQISFTKE EIAACKKAWP
     251  RIRDFKSLGT NINTAPASPE EPKEKRSGLI KDFNKFERPN IPVEEILITP
     301  RKNITDANCS DFSNTPSPYN EAPKMSNLDV VVEKRKFTPI EPSLLGPTPS
     351  LEYSPIKNKS LSYYSPTISK YLTYDTEFYT RRSRAREEDL NYYQTFKYSP
     401  SHYSPMRRER MTEEQFLEKV VQLQNICRGV NTRFNLYIQK RLLNLFEQDI
     451  LRFQACLRGN KFRVLSSMYL PIRRAKIDVP HVEAIQSRIK GSRIRYKYDK
     501  LKFTLSRFSC TVELLQAYCR SKLLKTTVNT KLNDIEISHY PLTKLQSYMR
     551  ASYVRKKVMS LNTKLNDERE SIMKFSAIIR GNVVRCSEDA ILSAVHDVHK
     601  ENISKLQSLI RGIFTRSCLA SIIYSLGKEN CNIIQLSACI RGNAVRHKVQ
     651  SLFAPENNLS ETVHDLQGLV RGILVRYTLD LVDDIVEYNN LALFQAFSRG
     701  ALVRESLDQK SSFYKRNVRS VIMIQSWIRK SLQRSAYLEL LDCPNPSLWA
     751  VKKFVHLLNG TATIEEVQNQ LESCQASLDS ENMKKERLLK SIRQQLNING
     801  VLDKFGLLKD KDHELGISDS TIPKSKYQKY EKLFYMLQVD PSYWKLLYLK
     851  EPEFVAKNVY MTFGTVNQRM NDRERSYFTR FVCEMLQNAI NEAPSIESFL
     901  DNRSQFWQTI LQDFLRRESP EFFSIIVPVL DYLSDPVVDF ESDPYKIYQE
     951  IHGFSSPQHC SPVDDASTKN KFIDNLRCLW HAIEMVAEIY TRKVHTIPVE
    1001  IRYLCTKIFC YAADKNIEEI DSLRAISSIL VNVFVSEYLV NREYYGYKDS
    1051  NVQKNNQKID ILMKSLATVF EIKNFDGFLD PLNQYANEIK PHIKDVLYNV
    1101  LVDPEYEQEG DRLIYLDMVS PSPKLELLTE KVLEISGKFE EYLNEFPEAD
    1151  ILHDILEKNL DNSSFPRSGR VTLELDASAY RFLVSDDKMR KIYDQVKRAF
    1201  VYMMQIEDVD TNLYDLSIST ILPQDEPNFA NFLEQNPKIR DDPMIQKLKP
    1251  LKYFTLKNVT LKKIHELEST GTFCSSDNKL QNFLNDIANT IKNPNYAIDY
    1301  VTQEIYITKE TLTKISEMNH SLDIELSRLK KHVDHTIKDF QKAKDFSPVH
    1351  KSKFGNFKNA VKKVQGRERS ELQGMKFKWN TKQLYERGVL KTIRGEKLAE
    1401  LTVKVFGSSG PKFPDIIFKI STSDGSRFGI QMIDKRKGPD KRYSDDVDSF
    1451  SFKDLIKTQV EPKIETWKLF HSNVVVNNSQ LLHLIVSFFY KRNAL*

external links for Iqg1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS	YeastRC Public Image Repository
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Iqg1p

1)	Lippincott J and Li R (1998) Sequential assembly of myosin II, an IQGAP-like protein, and filamentous actin to a ring structure involved in budding yeast cytokinesis. J Cell Biol 140(2):355-66
2)	Epp JA and Chant J (1997) An IQGAP-related protein controls actin-ring formation and cytokinesis in yeast. Curr Biol 7(12):921-9
3)	Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41