ENV7/YPL236C Protein Information Help

Standard Name Env7p 1
Systematic Name Ypl236cp
ORF Classification Verified
Description Vacuolar membrane protein kinase; negatively regulates membrane fusion; associates with vacuolar membrane through palmitoylation of one or more cysteines in consensus sequence; vacuolar membrane association is essential to its kinase activity; mutant shows defect in CPY processing; ortholog of human serine/threonine kinase 16 (STK16) (1, 2)
Name Description late ENdosome and Vacuole interface function 1
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 364
Molecular Weight (Da) 40,748
Isoelectric Point (pI) 4.88

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Env7p (InterPro)
Physical Interactions There are 9 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000006B12E | Q12003
MIPS: YPL236C
NCBI: 1061253 | 1370488 | 2326841 | 6325020 | 74676496 | NP_015088.1 | NM_001184050.1
GenBank/EMBL/DDBJ: CAA91608.1 | CAA97953.1 | CAA97954.1 | DAA11200.1 | Z67751 | Z73591 | Z73592
External Classifications EC: 2.7.11.1 [Non-specific serine/threonine protein kinase]
Amino Acid Sequence (or in FASTA format)
       1  MISIVLELFQ NLCCCRGFSD ATIRVNDKRY RIQRLLGEGG MSFVYLVQLS
      51  KNSLIIDNGI ATPELYALKK IICPSVESIS NGMREIENYK RFQSPYVIKS
     101  IDSQVMQEKD GSKTIYIVLP YYSLGSLQDS INRRLLEGTF VSEAECVRIM
     151  LGVTRGLLCL HDPASRQDNA TSRVNVDAVS MTYSDETAML LEDTPLEMDM
     201  LSSNSAGSIA YAHRDITPSN ILFSSDGLPV IGDLGSCSQA DITIENRHQL
     251  SELQEWVNDN CTLPYTPPEL LNLKLNQVLS SKVDIWSLGC TFYTLMFGIS
     301  PFEREEQIHG ASLTYAINTG KYSFPRNSRF SEGLLSVIKK CIQVDPIQRP
     351  TTSQLLNLLQ DLDT*                                      

external links for Env7p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily LoQate
Ashbya (AGD) BOND GPMdb (Mass Spec.) Organelle DB
Aspergillus (AspGD) CYC2008 (complexes) MIPS YPL+
Candida (CGD) Complexome Pfam domains YeastGFP
YGOB DIP YeastRC Structure Prediction (Seattle) YeastRC Public Image Repository
YOGY GeneMANIA


IMP


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Env7p
1) Ricarte F, et al.  (2011) A Genome-Wide Immunodetection Screen in S. cerevisiae Uncovers Novel Genes Involved in Lysosomal Vacuole Function and Morphology. PLoS One 6(8):e23696
2) Manandhar SP, et al.  (2013) Saccharomyces cerevisiae Env7 is a novel serine/threonine kinase 16-related protein kinase and negatively regulates organelle fusion at the lysosomal vacuole. Mol Cell Biol 33(3):526-42