RPL1A/YPL220W Protein Information

Standard Name	Rpl1ap
Systematic Name	Ypl220wp
Alias	Ssm1p
ORF Classification	Verified
Description	Ribosomal 60S subunit protein L1A; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1A has a paralog, RPL1B, that arose from the whole genome duplication; rpl1a rpl1b double null mutation is lethal (1, 2, 3, 4, 5)
Name Description	Ribosomal Protein of the Large subunit
Gene Product	L1 5 , L1A 2

Experimental Data
Molecules/cell	116000 6

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	217
Molecular Weight (Da)	24,486
Isoelectric Point (pI)	10.51

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Rpl1ap (InterPro)
Physical Interactions	There are 132 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000132EB6 \| P0CX43 MIPS: YPL220W NCBI: 119390529 \| 1370456 \| 315113301 \| 315113526 \| 315113571 \| 338819279 \| 398364437 \| 49258839 \| 6325036 \| 732949 \| NP_011380.3 \| NP_011385.3 \| NP_015104.1 GenBank/EMBL/DDBJ: DAA11216.1 \| X70985 \| Z73576

Amino Acid Sequence (or in FASTA format)
1 MSKITSSQVR EHVKELLKYS NETKKRNFLE TVELQVGLKN YDPQRDKRFS 51 GSLKLPNCPR PNMSICIFGD AFDVDRAKSC GVDAMSVDDL KKLNKNKKLI 101 KKLSKKYNAF IASEVLIKQV PRLLGPQLSK AGKFPTPVSH NDDLYGKVTD 151 VRSTIKFQLK KVLCLAVAVG NVEMEEDVLV NQILMSVNFF VSLLKKNWQN 201 VGSLVVKSSM GPAFRLY*

Amino Acid Sequence (or in FASTA format)

       1  MSKITSSQVR EHVKELLKYS NETKKRNFLE TVELQVGLKN YDPQRDKRFS
      51  GSLKLPNCPR PNMSICIFGD AFDVDRAKSC GVDAMSVDDL KKLNKNKKLI
     101  KKLSKKYNAF IASEVLIKQV PRLLGPQLSK AGKFPTPVSH NDDLYGKVTD
     151  VRSTIKFQLK KVLCLAVAVG NVEMEEDVLV NQILMSVNFF VSLLKKNWQN
     201  VGSLVVKSSM GPAFRLY*

external links for Rpl1ap

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	GeneMANIA
YOGY	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Rpl1ap

1)	Petitjean A, et al. (1995) The duplicated Saccharomyces cerevisiae gene SSM1 encodes a eucaryotic homolog of the eubacterial and archaebacterial L1 ribosomal proteins. Mol Cell Biol 15(9):5071-81
2)	Planta RJ and Mager WH (1998) The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae. Yeast 14(5):471-7
3)	Lecompte O, et al. (2002) Comparative analysis of ribosomal proteins in complete genomes: an example of reductive evolution at the domain scale. Nucleic Acids Res 30(24):5382-90
4)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
5)	Jenner L, et al. (2012) Crystal structure of the 80S yeast ribosome. Curr Opin Struct Biol 22(6):759-67
6)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41