BMS1/YPL217C Protein Information Help

Standard Name Bms1p 1
Systematic Name Ypl217cp
ORF Classification Verified
Description GTPase required for synthesis of 40S ribosomal subunits and for processing the 35S pre-rRNA at sites A0, A1, and A2; interacts with Rcl1p, which stimulates its GTPase and U3 snoRNA binding activities; has similarity to Tsr1p (1, 2, 3)
Name Description BMh Sensitive 1, 4
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 1,183
Molecular Weight (Da) 135,570
Isoelectric Point (pI) 6.79

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Bms1p (InterPro)
Physical Interactions There are 160 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000053016 | Q08965
MIPS: YPL217C
NCBI: 1370450 | 27151473 | 6325039 | NP_015107.1
GenBank/EMBL/DDBJ: DAA11219.1 | Z73573
Amino Acid Sequence (or in FASTA format)
 
       1  MEQSNKQHRK AKEKNTAKKK LHTQGHNAKA FAVAAPGKMA RTMQRSSDVN
      51  ERKLHVPMVD RTPEDDPPPF IVAVVGPPGT GKTTLIRSLV RRMTKSTLND
     101  IQGPITVVSG KHRRLTFLEC PADDLNAMID IAKIADLVLL LIDGNFGFEM
     151  ETMEFLNIAQ HHGMPRVLGV ATHLDLFKSQ STLRASKKRL KHRFWTEVYQ
     201  GAKLFYLSGV INGRYPDREI LNLSRFISVM KFRPLKWRNE HPYMLADRFT
     251  DLTHPELIET QGLQIDRKVA IYGYLHGTPL PSAPGTRVHI AGVGDFSVAQ
     301  IEKLPDPCPT PFYQQKLDDF EREKMKEEAK ANGEITTAST TRRRKRLDDK
     351  DKLIYAPMSD VGGVLMDKDA VYIDIGKKNE EPSFVPGQER GEGEKLMTGL
     401  QSVEQSIAEK FDGVGLQLFS NGTELHEVAD HEGMDVESGE ESIEDDEGKS
     451  KGRTSLRKPR IYGKPVQEED ADIDNLPSDE EPYTNDDDVQ DSEPRMVEID
     501  FNNTGEQGAE KLALETDSEF EESEDEFSWE RTAANKLKKT ESKKRTWNIG
     551  KLIYMDNISP EECIRRWRGE DDDSKDESDI EEDVDDDFFR KKDGTVTKEG
     601  NKDHAVDLEK FVPYFDTFEK LAKKWKSVDA IKERFLGAGI LGNDNKTKSD
     651  SNEGGEELYG DFEDLEDGNP SEQAEDNSDK ESEDEDENED TNGDDDNSFT
     701  NFDAEEKKDL TMEQEREMNA AKKEKLRAQF EIEEGENFKE DDENNEYDTW
     751  YELQKAKISK QLEINNIEYQ EMTPEQRQRI EGFKAGSYVR IVFEKVPMEF
     801  VKNFNPKFPI VMGGLLPTEI KFGIVKARLR RHRWHKKILK TNDPLVLSLG
     851  WRRFQTLPIY TTTDSRTRTR MLKYTPEHTY CNAAFYGPLC SPNTPFCGVQ
     901  IVANSDTGNG FRIAATGIVE EIDVNIEIVK KLKLVGFPYK IFKNTAFIKD
     951  MFSSAMEVAR FEGAQIKTVS GIRGEIKRAL SKPEGHYRAA FEDKILMSDI
    1001  VILRSWYPVR VKKFYNPVTS LLLKEKTEWK GLRLTGQIRA AMNLETPSNP
    1051  DSAYHKIERV ERHFNGLKVP KAVQKELPFK SQIHQMKPQK KKTYMAKRAV
    1101  VLGGDEKKAR SFIQKVLTIS KAKDSKRKEQ KASQRKERLK KLAKMEEEKS
    1151  QRDKEKKKEY FAQNGKRTTM GGDDESRPRK MRR*

external links for Bms1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Candida (CGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CandidaDB) CYC2008 (complexes) Pfam domains
YGOB Complexome YeastRC Structure Prediction (Seattle)
YOGY DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Bms1p
1) Gelperin D, et al.  (2001) Bms1p, a novel GTP-binding protein, and the related Tsr1p are required for distinct steps of 40S ribosome biogenesis in yeast. RNA 7(9):1268-83
2) Wegierski T, et al.  (2001) Bms1p, a G-domain-containing protein, associates with Rcl1p and is required for 18S rRNA biogenesis in yeast. RNA 7(9):1254-67
3) Karbstein K, et al.  (2005) An essential GTPase promotes assembly of preribosomal RNA processing complexes. Mol Cell 20(4):633-43
4) Gelperin D, et al.  (2002) Loss of ypk1 function causes rapamycin sensitivity, inhibition of translation initiation and synthetic lethality in 14-3-3-deficient yeast. Genetics 161(4):1453-64