CBP3/YPL215W Protein Information Help

Standard Name Cbp3p 1
Systematic Name Ypl215wp
ORF Classification Verified
Description Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex; Cbp3p-Cbp6p complex is sequestered if assembly of Complex III is blocked, downregulating COB mRNA translation (2, 3, 4, 5)
Name Description Cytochrome B mRNA Processing 1
Experimental Data
Molecules/cell 14200 6
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 335
Molecular Weight (Da) 39,083
Isoelectric Point (pI) 10.18

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Cbp3p (InterPro)
Physical Interactions There are 18 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI00001271BF | P21560
MIPS: YPL215W
NCBI: 115875 | 1370446 | 171171 | 6325041 | NP_015109.1 | NM_001184029.1
GenBank/EMBL/DDBJ: AAA34475.1 | CAA97930.1 | DAA11221.1 | J04830 | Z73571
Amino Acid Sequence (or in FASTA format)
       1  MMSVNRFTSG RLPVFLRKSP FYYSRAYLHQ TCVFKQNKET AQDSPELLAK
      51  SSHLNSKPLD VSNKAPVKTA QNKIPLAHSK YESSKYELPK WKEALGELVI
     101  RAFHLDMDRV RAGPVAGSYY YKICKEQGLQ YEDEPLSETA KYFYEDLKLP
     151  RTFSQWFQIT VLHEWILFVR MRAMPFKYGR NYQQKLVDRT FSDIELRLFE
     201  EMKVNSGRIA DQYLKDFNTQ LRGAIFAYDE GFATDDGTLA TAVWRNLFGG
     251  RKNIDMVHLE SVVRYIYSQL YVLSRLSDRE FATGKFKFVP PGVKVEKLTP
     301  KQEEELKAKT IAKYEALDKD PKTLPSERSR LSYTN*               

external links for Cbp3p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily LoQate
Ashbya (AGD) BOND GPMdb (Mass Spec.) Organelle DB
Candida (CGD) CYC2008 (complexes) MIPS YPL+
YGOB Complexome Pfam domains YeastGFP
YOGY DIP YeastRC Structure Prediction (Seattle) YeastRC Public Image Repository

GeneMANIA


IMP

References cited on this page View Complete Literature Guide for Cbp3p
1) Wu M and Tzagoloff A  (1989) Identification and characterization of a new gene (CBP3) required for the expression of yeast coenzyme QH2-cytochrome c reductase. J Biol Chem 264(19):11122-30
2) Shi G, et al.  (2001) Identification of functional regions of Cbp3p, an enzyme-specific chaperone required for the assembly of ubiquinol-cytochrome c reductase in yeast mitochondria. Biochim Biophys Acta 1506(2):103-16
3) Kronekova Z and Rodel G  (2005) Organization of assembly factors Cbp3p and Cbp4p and their effect on bc(1) complex assembly in Saccharomyces cerevisiae. Curr Genet 47(4):203-12
4) Gruschke S, et al.  (2011) Cbp3-Cbp6 interacts with the yeast mitochondrial ribosomal tunnel exit and promotes cytochrome b synthesis and assembly. J Cell Biol 193(6):1101-14
5) Gruschke S, et al.  (2012) The Cbp3-Cbp6 complex coordinates cytochrome b synthesis with bc(1) complex assembly in yeast mitochondria. J Cell Biol 199(1):137-50
6) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41