LEA1/YPL213W Protein Information

Standard Name	Lea1p 1
Systematic Name	Ypl213wp
ORF Classification	Verified
Description	Component of U2 snRNP; disruption causes reduced U2 snRNP levels; physically interacts with Msl1p; putative homolog of human U2A' snRNP protein (1)
Name Description	Looks Exceptionally like U2A 1

Experimental Data
Molecules/cell	3630 2

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	238
Molecular Weight (Da)	27,193
Isoelectric Point (pI)	7.64

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Lea1p (InterPro)
Physical Interactions	There are 213 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000052EF6 \| Q08963 MIPS: YPL213W NCBI: 1370442 \| 45270164 \| 6325043 \| 73919132 \| NP_015111.1 \| NM_001184027.1 GenBank/EMBL/DDBJ: DAA11223.1 \| AY558137 \| Z73569

Amino Acid Sequence (or in FASTA format)
1 MKFTPSIVID APQYYVDHFN GKYNVDKCVI LRDLQLETDS ESMPSSLKHL 51 TKPTHILDLT NNDLIMIPDL SRRDDIHTLL LGRNNIVEVD GRLLPMNVQN 101 LTLSNNSIRR FEDLQRLRRA PRTLKNLTLI GNQVCHLANY REHVLRLVPH 151 LETLDFQNVT AEERKSAMSF PRQADGDTLG PVNTAIRDNG SRDKTMEIMN 201 LVVSKMTVER RNELKKQLAE ATSLEEIARL EKLLSGGV*

Amino Acid Sequence (or in FASTA format)

       1  MKFTPSIVID APQYYVDHFN GKYNVDKCVI LRDLQLETDS ESMPSSLKHL
      51  TKPTHILDLT NNDLIMIPDL SRRDDIHTLL LGRNNIVEVD GRLLPMNVQN
     101  LTLSNNSIRR FEDLQRLRRA PRTLKNLTLI GNQVCHLANY REHVLRLVPH
     151  LETLDFQNVT AEERKSAMSF PRQADGDTLG PVNTAIRDNG SRDKTMEIMN
     201  LVVSKMTVER RNELKKQLAE ATSLEEIARL EKLLSGGV*

external links for Lea1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Candida (CGD)	BioPIXIE	MIPS	YeastGFP
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA
	YeastRC Mass Spec (Seattle)

References cited on this page View Complete Literature Guide for Lea1p

1)	Caspary F and Seraphin B (1998) The yeast U2A'/U2B complex is required for pre-spliceosome formation. EMBO J 17(21):6348-58
2)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41