IPL1/YPL209C Protein Information 
| Standard Name | Ipl1p 1 |
|---|---|
| Systematic Name | Ypl209cp |
| Alias | Pac15p 2 |
| ORF Classification | Verified |
| Description | Aurora kinase subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), involved in regulating kinetochore-microtubule attachments; helps maintain condensed chromosomes during anaphase and early telophase; required for SPB cohesion and prevention of multipolar spindle formation; localizes to nuclear foci that become diffuse upon DNA replication stress; required for inhibition of karyopherin/importin Pse1p (aka Kap121p) upon SAC arrest (3, 4, 5, 6, 7, 8, 9) |
| Name Description | Increase in PLoidy 1 |
| Experimental Data | |
|---|---|
| Molecules/cell | 149 10 |
| Click on image for expanded interactive view |
|---|
| Post-translational Modifications | PhosphoGRID | PhosphoPep Database |
|---|---|
| Domains/motifs | See the graphical view and list of proteins that share domains/motifs in common with Ipl1p (InterPro) |
| Physical Interactions | There are 139 total physical interactions (BioGRID) |
| Homologs | PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer |
| External Sequence Databases |
EBI: UPI000012D7F6 | P38991 MIPS: YPL209C NCBI: 1370434 | 460244 | 51013815 | 6325047 | 729855 | NP_015115.1 GenBank/EMBL/DDBJ: DAA11227.1 | AY693182 | U07163 | Z73565 |
| External Classifications | EC: 2.7.11.1 [Non-specific serine/threonine protein kinase] |
external links for Ipl1p
| Homologs | Interaction Resources | Protein databases/Other | Localization Resources |
|---|---|---|---|
| BLASTP (NCBI) | BioGRID | SCOP Superfamily | Organelle DB |
| Ashbya (AGD) | BOND | GPMdb (Mass Spec.) | YPL+ |
| Candida (CGD) | BioPIXIE | MIPS | YeastGFP |
| Candida (CandidaDB) | CYC2008 (complexes) | Pfam domains | YeastRC Public Image Repository |
| YGOB | Complexome | YeastRC Structure Prediction (Seattle) | |
| YOGY | DIP | ||
| GeneMANIA | |||
| YeastRC Mass Spec (Seattle) | |||
| YeastRC Two-Hybrid (Seattle) |
References cited on this page View Complete Literature Guide for Ipl1p
| 1) | Chan CS and Botstein D (1993) Isolation and characterization of chromosome-gain and increase-in-ploidy mutants in yeast. Genetics 135(3):677-91 |
| 2) | Geiser JR, et al. (1997) Saccharomyces cerevisiae genes required in the absence of the CIN8-encoded spindle motor act in functionally diverse mitotic pathways. Mol Biol Cell 8(6):1035-50 |
| 3) | Kang Js JS, et al. (2001) Functional cooperation of Dam1, Ipl1, and the inner centromere protein (INCENP)-related protein Sli15 during chromosome segregation. J Cell Biol 155(5):763-74 |
| 4) | Cheeseman IM, et al. (2002) Phospho-regulation of kinetochore-microtubule attachments by the Aurora kinase Ipl1p. Cell 111(2):163-72 |
| 5) | Vas AC, et al. (2007) In vivo analysis of chromosome condensation in Saccharomyces cerevisiae. Mol Biol Cell 18(2):557-68 |
| 6) | Nakajima Y, et al. (2009) Nbl1p: a Borealin/Dasra/CSC-1-like protein essential for Aurora/Ipl1 complex function and integrity in Saccharomyces cerevisiae. Mol Biol Cell 20(6):1772-84 |
| 7) | Shirk K, et al. (2011) The Aurora kinase Ipl1 is necessary for spindle pole body cohesion during budding yeast meiosis. J Cell Sci 124(Pt 17):2891-6 |
| 8) | Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76 |
| 9) | Cairo LV, et al. (2013) Mitosis-specific regulation of nuclear transport by the spindle assembly checkpoint protein Mad1p. Mol Cell 49(1):109-20 |
| 10) | Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41 |
