APL5/YPL195W Protein Information Help

Standard Name Apl5p 1
Systematic Name Ypl195wp
Alias Yks4p 2
ORF Classification Verified
Description Delta adaptin-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway, suppressor of loss of casein kinase 1 function (1, 2, 3)
Name Description clathrin Adaptor Protein complex Large chain 1
Experimental Data
Molecules/cell 13500 4
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 932
Molecular Weight (Da) 106,923
Isoelectric Point (pI) 4.8

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Apl5p (InterPro)
Physical Interactions There are 46 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI00000530A7 | Q08951
MIPS: YPL195W
NCBI: 1036843 | 1370407 | 6325061 | 74627252 | NP_015129.1 | NM_001184009.1
GenBank/EMBL/DDBJ: DAA11239.1 | U36858 | Z73551
Amino Acid Sequence (or in FASTA format)
 
       1  MTSLYAPGAE DIRQRLRPFG FFFEKSLKDL IKGIRSHNET PEKLDQFFKQ
      51  VLSECREEVN SPDLNSKTNA VLKLTYLEMY GFDMAWCNFH ILEVMSSNKL
     101  QQKRVGYLAA SQSFYKDSDI LMLATNLLKK DLKYDGNNDV VKVGIALSGL
     151  STIITPSLAR DIADDLFTML NSTRPYIRKK AITALFKVFL QYPEALRDNF
     201  DKFVSKLDDD DISVVSAAVS VICELSKKNP QPFIQLSPLL YEILVTIDNN
     251  WIIIRLLKLF TNLSQVEPKL RAKLLPKILE LMESTVATSV IYESVNCIVK
     301  GNMLEEDDFE TAMACLERLH TFCDSQDPNL RYISCILFYK IGKINTDFIS
     351  RFDQLIIRLL SDVDVSIRSK AIELVEGIVD EDNLKAIVQT LMKQFVDEDV
     401  VILQTGSIVY EKSKRIPIII PENYKIKMVN VIISICSADN YSSVNDFEWY
     451  NAVIMDLAML CQDISDKSLG SKIGEQFRNL MIKVPSMREV TIANIIKLIS
     501  NDNINKQLPT VLRECIWCLG EFSTLVENGN DLIKIMTENI SYYSHSVQEV
     551  LILALVKVFS NWCNNFQEDK RFEIKMVLKE LIEFFENLSY SSTFEVQERS
     601  VEVLEFLRLS LEALEEDTEG LPMLLSEVLP SFFNAYELAP IARGTQLKLA
     651  VDENLDLETP FLTKEAADEL LDEQKSDAIS DLMSDISMDE QVELKFVDDS
     701  DTSYEEKEKL DDFENPFEIE REKERMSNPY YLGEEDEERT KNSKDLLDLN
     751  EEESSDKKPE TIRLNRTDNS LNSLSLSTTE ISRKKKKGKK KNRVQVLSDE
     801  PVIEAAPKRK DAFQKPHDNH STQNPLKKDK INLRMHSQLE NFDFSNFGQS
     851  SNAGRGSQEE GNLRKEDELE LSRLEANLIV KDEKDNLSDT EEVIVIKKKK
     901  KGKKSKSKNK LKTKAKNSPE PNEFLRDQST DI*

external links for Apl5p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Aspergillus (AspGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CGD) CYC2008 (complexes) Pfam domains
Candida (CandidaDB) Complexome YeastRC Structure Prediction (Seattle)
YGOB DIP

YOGY GeneMANIA

References cited on this page View Complete Literature Guide for Apl5p
1) Cowles CR, et al.  (1997) The AP-3 adaptor complex is essential for cargo-selective transport to the yeast vacuole. Cell 91(1):109-18
2) Panek HR, et al.  (1997) Suppressors of YCK-encoded yeast casein kinase 1 deficiency define the four subunits of a novel clathrin AP-like complex. EMBO J 16(14):4194-204
3) Rehling P, et al.  (1999) Formation of AP-3 transport intermediates requires Vps41 function. Nat Cell Biol 1(6):346-53
4) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41