RTT10/YPL183C Protein Information Help

Standard Name Rtt10p 1
Systematic Name Ypl183cp
Alias Ere2p 2 , Trm734p 3
ORF Classification Verified
Description WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rrt2p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; evidence it interacts with Trm7p for 2'-O-methylation of N34 of substrate tRNAs; has a role in regulation of Ty1 transposition; human ortholog is WDR6 (1, 2, 3, 4)
Name Description Regulator of Ty1 Transposition 1, 5
Experimental Data
Molecules/cell 3450 6
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 1,013
Molecular Weight (Da) 114,460
Isoelectric Point (pI) 6.1

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Rtt10p (InterPro)
Physical Interactions There are 11 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000006C45A | Q08924
MIPS: YPL183C
NCBI: 1370384 | 6325074 | 74676484 | NP_015142.1
GenBank/EMBL/DDBJ: DAA11252.1 | Z73539
Amino Acid Sequence (or in FASTA format)
 
       1  MKDLSHYGPA LCVKFYNDYV LAGYGPFIHV YDYHSATLIN KCRLFHYNKV
      51  HGLSLSSEGK ILAYGARSVT IVELEDVLKK ESLVDFERIN SDWITGATFS
     101  FDNLQIYLLT CYNKVLICDL NCEVLFRKSL GGERSILYSG IIKVFGPDKV
     151  YVNAGTVMGG VIIWDLFSET KIHNLLGHEG SIFYVNLSNN GRYVASCSDD
     201  RSIRLWDLET GKQLSVGWSH TARIWNLMFF DNDSKLISVS EDCTCRVWNI
     251  IESRENVAEL SISNVYEVHL IKSIWGVDVK DDEMIAVTSG NDGRLKLIDL
     301  LQLKRHGDEE TSFSLDDIAK QCGDIFEKNE SIKGFQWFSF GVIAITSLGK
     351  ILKYSDVTKQ WKLLLTNEKF NSYPITNGIQ TQNIAVFSNN KSDILLIKFS
     401  KDSADIIETE EFHLDELSKT NNCLVTEYDD DSFLLTLQSP NPREKFVCLE
     451  ISLQNLKIKS KHCFNKPENF SSSCLTSFRN HILVGSRFST LVIYNLLDES
     501  EEPFIIRRLS PGDTTTSIEF VEDKDNSAVF SVTNRDGYYV FIELTKNSLE
     551  EGPYRLSYKV LHSNKMMKGF LEGAFFNSKG EYITYGFKSS LFYLYNETNC
     601  YELASEVCGG SHRLWNLAKI TDGHVLMYIK ASRFHLRKIY NSIVPETLEN
     651  GVHGREIRDI SICPVSNTNT NDNFKDGHIF CTASEDTTIK LGYFNNRTGK
     701  VQNFWTQRKH VSGLQRCQFI NHKLMISSSA REELFLWELN DKYNKRPYMT
     751  IRQALPVSTN NSDLRIMDFD VKFISQSGDF LLVTVYSDST IKIWHYRENQ
     801  NKFDLIMQGR YKTCCLFNVV FIALKEELLV VISPTDGHLV VYNITEYVPF
     851  SVDPISGDLV DHKLDATISN LPAPVAQLPV HQSGVKSLDY VANATRTSAT
     901  ILTGGDDNGL GLSNLKLDDS NKVTLKTSDF IAAAASSTIT SGMLINGGKE
     951  VITTSVDQVI RAWEITAGKL SLVDKKRTTV ADTGSLEIIS NDEDADSEKT
    1001  LLIGGVGLSI WKK*

external links for Rtt10p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Aspergillus (AspGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CGD) CYC2008 (complexes) Pfam domains
Candida (CandidaDB) Complexome YeastRC Structure Prediction (Seattle)
YGOB GeneMANIA

YOGY


References cited on this page View Complete Literature Guide for Rtt10p
1) Nyswaner KM, et al.  (2008) Chromatin-associated genes protect the yeast genome from ty1 insertional mutagenesis. Genetics 178(1):197-214
2) Shi Y, et al.  (2011) Two novel WD40 domain-containing proteins, Ere1 and Ere2, function in the retromer-mediated endosomal recycling pathway. Mol Biol Cell 22(21):4093-107
3) Guy MP, et al.  (2012) Yeast Trm7 interacts with distinct proteins for critical modifications of the tRNAPhe anticodon loop. RNA 18(10):1921-33
4) Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
5) Scholes DT, et al.  (2001) Multiple regulators of Ty1 transposition in Saccharomyces cerevisiae have conserved roles in genome maintenance. Genetics 159(4):1449-65
6) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41