OYE3/YPL171C Protein Information

Standard Name	Oye3p
Systematic Name	Ypl171cp
Alias	Zrg6p 1
ORF Classification	Verified
Description	Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye2p with different ligand binding and catalytic properties; has potential roles in oxidative stress response and programmed cell death (2, 3, 4, 5, 6)
Name Description	Old Yellow Enzyme 2
Gene Product	Old Yellow Enzyme

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	400
Molecular Weight (Da)	44,920
Isoelectric Point (pI)	5.4

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Oye3p (InterPro)
Physical Interactions	There are 11 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000153C8C \| P41816 MIPS: YPL171C NCBI: 1171946 \| 1370361 \| 1403538 \| 2326834 \| 460039 \| 51013903 \| 6325086 \| NP_015154.1 GenBank/EMBL/DDBJ: DAA11263.1 \| AY693226 \| L29279 \| X96770 \| Z73526 \| Z73527
External Classifications	EC: 1.6.99.1 [NADPH dehydrogenase]

Amino Acid Sequence (or in FASTA format)
1 MPFVKGFEPI SLRDTNLFEP IKIGNTQLAH RAVMPPLTRM RATHPGNIPN 51 KEWAAVYYGQ RAQRPGTMII TEGTFISPQA GGYDNAPGIW SDEQVAEWKN 101 IFLAIHDCQS FAWVQLWSLG WASFPDVLAR DGLRYDCASD RVYMNATLQE 151 KAKDANNLEH SLTKDDIKQY IKDYIHAAKN SIAAGADGVE IHSANGYLLN 201 QFLDPHSNKR TDEYGGTIEN RARFTLEVVD ALIETIGPER VGLRLSPYGT 251 FNSMSGGAEP GIIAQYSYVL GELEKRAKAG KRLAFVHLVE PRVTDPSLVE 301 GEGEYSEGTN DFAYSIWKGP IIRAGNYALH PEVVREQVKD PRTLIGYGRF 351 FISNPDLVYR LEEGLPLNKY DRSTFYTMSA EGYTDYPTYE EAVDLGWNKN 401 *

Amino Acid Sequence (or in FASTA format)

       1  MPFVKGFEPI SLRDTNLFEP IKIGNTQLAH RAVMPPLTRM RATHPGNIPN
      51  KEWAAVYYGQ RAQRPGTMII TEGTFISPQA GGYDNAPGIW SDEQVAEWKN
     101  IFLAIHDCQS FAWVQLWSLG WASFPDVLAR DGLRYDCASD RVYMNATLQE
     151  KAKDANNLEH SLTKDDIKQY IKDYIHAAKN SIAAGADGVE IHSANGYLLN
     201  QFLDPHSNKR TDEYGGTIEN RARFTLEVVD ALIETIGPER VGLRLSPYGT
     251  FNSMSGGAEP GIIAQYSYVL GELEKRAKAG KRLAFVHLVE PRVTDPSLVE
     301  GEGEYSEGTN DFAYSIWKGP IIRAGNYALH PEVVREQVKD PRTLIGYGRF
     351  FISNPDLVYR LEEGLPLNKY DRSTFYTMSA EGYTDYPTYE EAVDLGWNKN
     401  *

external links for Oye3p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
YGOB	CYC2008 (complexes)	Pfam domains
YOGY	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Oye3p

1)	Yuan DS (2000) Zinc-regulated genes in Saccharomyces cerevisiae revealed by transposon tagging. Genetics 156(1):45-58
2)	Niino YS, et al. (1995) A new old yellow enzyme of Saccharomyces cerevisiae. J Biol Chem 270(5):1983-91
3)	Stott K, et al. (1993) Old Yellow Enzyme. The discovery of multiple isozymes and a family of related proteins. J Biol Chem 268(9):6097-106
4)	Brown BJ, et al. (2002) The role of glutamine 114 in old yellow enzyme. J Biol Chem 277(3):2138-45
5)	Trotter EW, et al. (2006) Old yellow enzymes protect against acrolein toxicity in the yeast Saccharomyces cerevisiae. Appl Environ Microbiol 72(7):4885-92
6)	Odat O, et al. (2007) Old Yellow Enzymes, Highly Homologous FMN Oxidoreductases with Modulating Roles in Oxidative Stress and Programmed Cell Death in Yeast. J Biol Chem 282(49):36010-23