MEX67/YPL169C Protein Information

Standard Name	Mex67p 1
Systematic Name	Ypl169cp
ORF Classification	Verified
Description	Poly(A)RNA binding protein involved in nuclear mRNA export, component of the nuclear pore; ortholog of human TAP (1, 2, 3, 4)
Name Description	Messenger RNA EXport factor of 67 kDa 1

Experimental Data
Molecules/cell	2830 5

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	599
Molecular Weight (Da)	67,351
Isoelectric Point (pI)	10.03

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Mex67p (InterPro)
Physical Interactions	There are 133 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000012FAA6 \| Q99257 MIPS: YPL169C NCBI: 1370357 \| 1403540 \| 159164718 \| 18202670 \| 237640370 \| 33357685 \| 6325088 \| NP_015156.1 GenBank/EMBL/DDBJ: DAA11265.1 \| X96770 \| Z73525

Amino Acid Sequence (or in FASTA format)
1 MSGFHNVGNI NMMAQQQMQQ NRIKISVRNW QNATMNDLIN FISRNARVAV 51 YDAHVEGPLV IGYVNSKAEA ESLMKWNGVR FAGSNLKFEL LDNNGASAGT 101 SDTISFLRGV LLKRYDPQTK LLNLGALHSD PELIQKGVFS SISTQSKMFP 151 AMMKLASTEK SLIVESVNLA DNQLKDISAI STLAQTFPNL KNLCLANNQI 201 FRFRSLEVWK NKFKDLRELL MTNNPITTDK LYRTEMLRLF PKLVVLDNVI 251 VRDEQKLQTV YSLPMKIQQF FFENDALGQS STDFATNFLN LWDNNREQLL 301 NLYSPQSQFS VSVDSTIPPS TVTDSDQTPA FGYYMSSSRN ISKVSSEKSI 351 QQRLSIGQES INSIFKTLPK TKHHLQEQPN EYSMETISYP QINGFVITLH 401 GFFEETGKPE LESNKKTGKN NYQKNRRYNH GYNSTSNNKL SKKSFDRTWV 451 IVPMNNSVII ASDLLTVRAY STGAWKTASI AIAQPPQQQA SVLPQVASMN 501 PNITTPPQPQ PSVVPGGMSI PGAPQGAMVM APTLQLPPDV QSRLNPVQLE 551 LLNKLHLETK LNAEYTFMLA EQSNWNYEVA IKGFQSSMNG IPREAFVQF*

Amino Acid Sequence (or in FASTA format)

       1  MSGFHNVGNI NMMAQQQMQQ NRIKISVRNW QNATMNDLIN FISRNARVAV
      51  YDAHVEGPLV IGYVNSKAEA ESLMKWNGVR FAGSNLKFEL LDNNGASAGT
     101  SDTISFLRGV LLKRYDPQTK LLNLGALHSD PELIQKGVFS SISTQSKMFP
     151  AMMKLASTEK SLIVESVNLA DNQLKDISAI STLAQTFPNL KNLCLANNQI
     201  FRFRSLEVWK NKFKDLRELL MTNNPITTDK LYRTEMLRLF PKLVVLDNVI
     251  VRDEQKLQTV YSLPMKIQQF FFENDALGQS STDFATNFLN LWDNNREQLL
     301  NLYSPQSQFS VSVDSTIPPS TVTDSDQTPA FGYYMSSSRN ISKVSSEKSI
     351  QQRLSIGQES INSIFKTLPK TKHHLQEQPN EYSMETISYP QINGFVITLH
     401  GFFEETGKPE LESNKKTGKN NYQKNRRYNH GYNSTSNNKL SKKSFDRTWV
     451  IVPMNNSVII ASDLLTVRAY STGAWKTASI AIAQPPQQQA SVLPQVASMN
     501  PNITTPPQPQ PSVVPGGMSI PGAPQGAMVM APTLQLPPDV QSRLNPVQLE
     551  LLNKLHLETK LNAEYTFMLA EQSNWNYEVA IKGFQSSMNG IPREAFVQF*

external links for Mex67p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Mex67p

1)	Segref A, et al. (1997) Mex67p, a novel factor for nuclear mRNA export, binds to both poly(A)+ RNA and nuclear pores. EMBO J 16(11):3256-71
2)	Rout MP, et al. (2000) The yeast nuclear pore complex: composition, architecture, and transport mechanism. J Cell Biol 148(4):635-51
3)	Katahira J, et al. (1999) The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human. EMBO J 18(9):2593-609
4)	Gruter P, et al. (1998) TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus. Mol Cell 1(5):649-59
5)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41