REV3/YPL167C Protein Information Help

Standard Name Rev3p 1
Systematic Name Ypl167cp
Alias Pso1p 2, 3
ORF Classification Verified
Description Catalytic subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair (4, 5, 6)
Name Description REVersionless 1
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 1,504
Molecular Weight (Da) 172,956
Isoelectric Point (pI) 8.86

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Rev3p (InterPro)
Physical Interactions There are 30 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000129839 | P14284
MIPS: YPL167C
NCBI: 118901 | 1370353 | 1403542 | 172387 | 6325090 | NP_015158.1
GenBank/EMBL/DDBJ: DAA11267.1 | M29683 | X96770 | Z73523
External Classifications EC: 2.7.7.7 [DNA-directed DNA polymerase]
Amino Acid Sequence (or in FASTA format)
 
       1  MSRESNDTIQ SDTVRSSSKS DYFRIQLNNQ DYYMSKPTFL DPSHGESLPL
      51  NQFSQVPNIR VFGALPTGHQ VLCHVHGILP YMFIKYDGQI TDTSTLRHQR
     101  CAQVHKTLEV KIRASFKRKK DDKHDLAGDK LGNLNFVADV SVVKGIPFYG
     151  YHVGWNLFYK ISLLNPSCLS RISELIRDGK IFGKKFEIYE SHIPYLLQWT
     201  ADFNLFGCSW INVDRCYFRS PVLNSILDID KLTINDDLQL LLDRFCDFKC
     251  NVLSRRDFPR VGNGLIEIDI LPQFIKNREK LQHRDIHHDF LEKLGDISDI
     301  PVKPYVSSAR DMINELTMQR EELSLKEYKE PPETKRHVSG HQWQSSGEFE
     351  AFYKKAQHKT STFDGQIPNF ENFIDKNQKF SAINTPYEAL PQLWPRLPQI
     401  EINNNSMQDK KNDDQVNASF TEYEICGVDN ENEGVKGSNI KSRSYSWLPE
     451  SIASPKDSTI LLDHQTKYHN TINFSMDCAM TQNMASKRKL RSSVSANKTS
     501  LLSRKRKKVM AAGLRYGKRA FVYGEPPFGY QDILNKLEDE GFPKIDYKDP
     551  FFSNPVDLEN KPYAYAGKRF EISSTHVSTR IPVQFGGETV SVYNKPTFDM
     601  FSSWKYALKP PTYDAVQKWY NKVPSMGNKK TESQISMHTP HSKFLYKFAS
     651  DVSGKQKRKK SSVHDSLTHL TLEIHANTRS DKIPDPAIDE VSMIIWCLEE
     701  ETFPLDLDIA YEGIMIVHKA SEDSTFPTKI QHCINEIPVM FYESEFEMFE
     751  ALTDLVLLLD PDILSGFEIH NFSWGYIIER CQKIHQFDIV RELARVKCQI
     801  KTKLSDTWGY AHSSGIMITG RHMINIWRAL RSDVNLTQYT IESAAFNILH
     851  KRLPHFSFES LTNMWNAKKS TTELKTVLNY WLSRAQINIQ LLRKQDYIAR
     901  NIEQARLIGI DFHSVYYRGS QFKVESFLIR ICKSESFILL SPGKKDVRKQ
     951  KALECVPLVM EPESAFYKSP LIVLDFQSLY PSIMIGYNYC YSTMIGRVRE
    1001  INLTENNLGV SKFSLPRNIL ALLKNDVTIA PNGVVYAKTS VRKSTLSKML
    1051  TDILDVRVMI KKTMNEIGDD NTTLKRLLNN KQLALKLLAN VTYGYTSASF
    1101  SGRMPCSDLA DSIVQTGRET LEKAIDIIEK DETWNAKVVY GDTDSLFVYL
    1151  PGKTAIEAFS IGHAMAERVT QNNPKPIFLK FEKVYHPSIL ISKKRYVGFS
    1201  YESPSQTLPI FDAKGIETVR RDGIPAQQKI IEKCIRLLFQ TKDLSKIKKY
    1251  LQNEFFKIQI GKVSAQDFCF AKEVKLGAYK SEKTAPAGAV VVKRRINEDH
    1301  RAEPQYKERI PYLVVKGKQG QLLRERCVSP EEFLEGENLE LDSEYYINKI
    1351  LIPPLDRLFN LIGINVGNWA QEIVKSKRAS TTTTKVENIT RVGTSATCCN
    1401  CGEELTKICS LQLCDDCLEK RSTTTLSFLI KKLKRQKEYQ TLKTVCRTCS
    1451  YRYTSDAGIE NDHIASKCNS YDCPVFYSRV KAERYLRDNQ SVQREEALIS
    1501  LNDW*

external links for Rev3p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Aspergillus (AspGD) BioPIXIE MIPS
Candida (CGD) CYC2008 (complexes) Pfam domains
Candida (CandidaDB) Complexome YeastRC Structure Prediction (Seattle)
YGOB GeneMANIA

YOGY


References cited on this page View Complete Literature Guide for Rev3p
1) Lemontt JF  (1971) Mutants of yeast defective in mutation induced by ultraviolet light. Genetics 68(1):21-33
2) Cassier-Chauvat C and Moustacchi E  (1988) Allelism between pso1-1 and rev3-1 mutants and between pso2-1 and snm1 mutants in Saccharomyces cerevisiae. Curr Genet 13(1):37-40
3) Henriques JA and Moustacchi E  (1980) Isolation and characterization of pso mutants sensitive to photo-addition of psoralen derivatives in Saccharomyces cerevisiae. Genetics 95(2):273-88
4) Prakash S, et al.  (2005) Eukaryotic translesion synthesis DNA polymerases: specificity of structure and function. Annu Rev Biochem 74:317-53
5) Kolas NK and Durocher D  (2006) DNA repair: DNA polymerase zeta and Rev1 break in. Curr Biol 16(8):R296-9
6) Lee KY and Myung K  (2008) PCNA Modifications for Regulation of Post-Replication Repair Pathways. Mol Cells 26(1):5-11